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Double-stranded DNA `overstretches' at a pulling force of about 65 pN, increasing in length by a factor of 1.7. The nature of the overstretched state is unknown, despite its considerable importance for DNA's biological function and…

Statistical Mechanics · Physics 2009-11-13 Stephen Whitelam , Sander Pronk , Phillip L. Geissler

The formation of bubbles in nucleic acids (NAs) are fundamental in many biological processes such as DNA replication, recombination, telomeres formation, nucleotide excision repair, as well as RNA transcription and splicing. These precesses…

Biomolecules · Quantitative Biology 2007-05-23 D. Hennig , J. F. R. Archilla , J. M. Romero

Weakly coupled semiconductor superlattices under dc voltage bias are nonlinear systems with many degrees of freedom whose nonlinearity is due to sequential tunneling of electrons. They may exhibit spontaneous chaos at room temperature and…

Mesoscale and Nanoscale Physics · Physics 2022-11-29 Luis L. Bonilla , Manuel Carretero , Emanuel Mompó

Short blunt-ended DNA duplexes comprising 6 to 20 base pairs self-assemble into polydisperse semi-flexible chains due to hydrophobic stacking interactions between terminal base pairs. Above a critical concentration, which depends on…

Soft Condensed Matter · Physics 2012-07-17 Cristiano De Michele , Lorenzo Rovigatti , Tommaso Bellini , Francesco Sciortino

A thin infinitely long elastic shell is stiffened by $J$ in number identical lengthwise ribs distributed uniformly around the circumference and joined to a rod in the center. The 2D model of the substructure is a rigid central mass…

Classical Physics · Physics 2015-12-09 Alexey S. Titovich , Andrew N. Norris

The base pair fluctuations and helix untwisting are examined for a circular molecule. A realistic mesoscopic model including twisting degrees of freedom and bending of the molecular axis is proposed. The computational method, based on path…

Biomolecules · Quantitative Biology 2013-05-30 Marco Zoli

We consider the problem of coding for the substring channel, in which information strings are observed only through their (multisets of) substrings. Due to existing DNA sequencing techniques and applications in DNA-based storage systems,…

Information Theory · Computer Science 2024-03-27 Yonatan Yehezkeally , Nikita Polyanskii

Understanding the inherent timescales of large bubbles in DNA is critical to a thorough comprehension of its physicochemical characteristics, as well as their potential role on helix opening and biological function. In this work we employ…

Biological Physics · Physics 2022-08-12 Malcolm Hillebrand , George Kalosakas , Alan R Bishop , Charalampos Skokos

We investigate the dynamical properties of a strongly disordered micropolar lattice made up of cubic block units. This phononic lattice model supports both transverse and rotational degrees of freedom hence its disordered variant posses an…

Pattern Formation and Solitons · Physics 2020-08-12 A. Ngapasare , G. Theocharis , O. Richoux , Ch. Skokos , V. Achilleos

We study the quantum dynamics of a strongly correlated electron pair in a one-dimensional lattice, focusing on the occurrence of local dissociation/pairing mechanisms induced by a site energy defect. To this end, we simulate the time…

Strongly Correlated Electrons · Physics 2025-06-17 Vincent Pouthier , Saad Yalouz

In solution, DNA is a highly charged macromolecule which bears a unit of negative charge on each phosphate of its sugar-phosphate backbone. Although partially compensated by counterions adsorbed at or condensed near it, DNA still produces a…

Soft Condensed Matter · Physics 2024-03-11 Jonathan G. Hedley , Kush Coshic , Aleksei Aksimentiev , Alexei A. Kornyshev

The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect…

Statistical Mechanics · Physics 2009-01-28 Marco Baiesi , Roberto Livi

We suggest that the thermodynamic stability parameters (nearest neighbor stacking and hydrogen bonding free energies) of double-stranded DNA molecules can be inferred reliably from time series of the size fluctuations (breathing) of local…

Biomolecules · Quantitative Biology 2011-10-28 Srijeeta Talukder , Pinaki Chaudhury , Ralf Metzler , Suman K Banik

We investigate the formation process of nonlinear vibrational modes representing broad H-bridge multi--site breathers in a DNA--shaped double strand. Within a network model of the double helix we take individual motions of the bases within…

Pattern Formation and Solitons · Physics 2009-11-10 D. Hennig , J. F. R. Archilla

The closure of long equilibrated denaturation bubbles in DNA is studied using Brownian dynamics simulations. A minimal mesoscopic model is used where the double-helix is made of two interacting bead-spring freely rotating strands, with a…

Soft Condensed Matter · Physics 2015-06-12 Anil Kumar Dasanna , Nicolas Destainville , John Palmeri , Manoel Manghi

We compare an analytic model for the evolution of supernova-driven superbubbles with observations of local and high-redshift galaxies, and the properties of intact HI shells in local star-forming galaxies. Our model correctly predicts the…

Astrophysics of Galaxies · Physics 2022-01-25 Matthew E. Orr , Drummond B. Fielding , Christopher C. Hayward , Blakesley Burkhart

The present paper develops the ideas introduced in {\em cond-mat/0312673}. The construction of a hybrid discrete-continuous model of layered superconductors is briefly presented. The model bases on the classic Lawrence-Doniach scenario with…

Superconductivity · Physics 2008-01-03 M. Sztyren

In this paper, using the generalized coupled pseudoforce model with driving elements, we develop a method to study the plasmon excitations and energy band structure in a plasmonic crystal. It is shown that the presence of the periodic ion…

Plasma Physics · Physics 2019-03-27 M. Akbari-Moghanjoughi

Under constant applied force, the separation of double-stranded DNA into two single strands is known to proceed through a series of pauses and jumps. Given experimental traces of constant-force unzipping, we present a method whereby the…

Soft Condensed Matter · Physics 2009-09-29 J. D. Weeks , J. B. Lucks , Y. Kafri , C. Danilowicz , D. R. Nelson , M. Prentiss

We obtain, using transfer matrix methods, the distribution function $P(R)$ of the end-to-end distance, the loop formation probability and force-extension relations in a model for short double-stranded DNA molecules. Accounting for the…

Soft Condensed Matter · Physics 2009-11-10 P. Ranjith , P. B. Sunil Kumar , Gautam I. Menon