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Motifs are patterns of subgraphs of complex networks. We studied the impact of such patterns of connectivity on the level of correlated, or synchronized, spiking activity among pairs of cells in a recurrent network model of integrate and…

Neurons and Cognition · Quantitative Biology 2015-06-05 Yu Hu , James Trousdale , Kresimir Josic , Eric Shea-Brown

Biological and technological networks contain patterns, termed network motifs, which occur far more often than in randomized networks. Network motifs were suggested to be elementary building blocks that carry out key functions in the…

Molecular Networks · Quantitative Biology 2009-11-10 N. Kashtan , S. Itzkovitz , R. Milo , U. Alon

The structure of the network can be described by motifs, which are subgraphs that often repeat themselves. In order to understand the structure of network motifs, it is of great importance to study subgraphs from the perspective of…

General Topology · Mathematics 2019-10-25 Ruize Gao , Ying Zhao

Physical and functional constraints on biological networks lead to complex topological patterns across multiple scales in their organization. A particular type of higher-order network feature that has received considerable interest is…

Quantitative Methods · Quantitative Biology 2024-10-15 Alexis Bénichou , Jean-Baptiste Masson , Christian L. Vestergaard

In physics, biology and engineering, network systems abound. How does the connectivity of a network system combine with the behavior of its individual components to determine its collective function? We approach this question for networks…

Neurons and Cognition · Quantitative Biology 2018-12-19 Yu Hu , Steven L. Brunton , Nicholas Cain , Stefan Mihalas , J. Nathan Kutz , Eric Shea-Brown

Recent evidence indicates that the abundance of recurring elementary interaction patterns in complex networks, often called subgraphs or motifs, carry significant information about their function and overall organization. Yet, the…

Disordered Systems and Neural Networks · Physics 2009-11-10 A. Vazquez , R. Dobrin , D. Sergi , J. -P. Eckmann , Z. N. Oltvai , A. -L. Barabasi

Networks are universally considered as complex structures of interactions of large multi-component systems. In order to determine the role that each node has inside a complex network, several centrality measures have been developed. Such…

Physics and Society · Physics 2019-08-20 Malbor Asllani , Bruno Requiao da Cunha , Ernesto Estrada , James P. Gleeson

Network motif provides a way to uncover the basic building blocks of most complex networks. This task usually demands high computer processing, specially for motif with 5 or more vertices. This paper presents an extended methodology with…

Data Structures and Algorithms · Computer Science 2018-04-27 Luis A. A. Meira , Vinícius R. Máximo , Alvaro L. Fazenda , Arlindo F. da Conceição

Routing information through networks is a universal phenomenon in both natural and manmade complex systems. When each node has full knowledge of the global network connectivity, finding short communication paths is merely a matter of…

Physics and Society · Physics 2009-05-20 Marian Boguna , Dmitri Krioukov , kc claffy

Network motifs are characteristic patterns which occur in the networks essentially more frequently than the other patterns. For five motifs found in S. Itzkovitz, U. Alon, Phys. Rev.~E, 2005, 71, 026117-1, hierarchical random graphs are…

Mathematical Physics · Physics 2015-04-02 Monika Kotorowicz , Yuri Kozitsky

Complex network theory aims to model and analyze complex systems that consist of multiple and interdependent components. Among all studies on complex networks, topological structure analysis is of the most fundamental importance, as it…

Social and Information Networks · Computer Science 2010-09-15 Bo Yang , Jiming Liu

Studying the topology of so-called {\em real networks}, that is networks obtained from sociological or biological data for instance, has become a major field of interest in the last decade. One way to deal with it is to consider that…

Applications · Statistics 2010-11-23 Etienne Birmele

Network science can offer fundamental insights into the structural and functional properties of complex systems. For example, it is widely known that neuronal circuits tend to organize into basic functional topological modules, called…

Adaptation and Self-Organizing Systems · Physics 2022-08-03 Matteo Zambra , Alberto Testolin , Amos Maritan

Conventionally, pairwise relationships between nodes are considered to be the fundamental building blocks of complex networks. However, over the last decade the overabundance of certain sub-network patterns, so called motifs, has attracted…

Physics and Society · Physics 2015-01-28 Marco Winkler , Joerg Reichardt

Developing and maintaining life requires a lot of computation. This is done by gene regulatory networks. But we have little understanding of how this computation is organized. I show that there is a direct correspondence between the…

Molecular Networks · Quantitative Biology 2022-09-01 Thomas M. A. Fink

Inspired by empirical studies of networked systems such as the Internet, social networks, and biological networks, researchers have in recent years developed a variety of techniques and models to help us understand or predict the behavior…

Statistical Mechanics · Physics 2015-06-24 M. E. J. Newman

Motif counting plays a crucial role in understanding the structural properties of networks. By computing motif frequencies, researchers can draw key insights into the structural properties of the underlying network. As networks become…

Social and Information Networks · Computer Science 2025-03-26 Haozhe Yin , Kai Wang , Wenjie Zhang , Yizhang He , Ying Zhang , Xuemin Lin

When studying a complex system it is often useful to think of the system as a network of interacting units. One can then ask if some properties of the entire network are already explained by a small part of the network - a network motif. A…

Populations and Evolution · Quantitative Biology 2025-09-03 Melanie Habermann , Ashkaan K. Fahimipour , Justin D. Yeakel , Thilo Gross

Networks are abundant in biological systems. Small sized over-represented network motifs have been discovered, and it has been suggested that these constitute functional building blocks. We ask whether larger dynamical network motifs exist…

Neural and Evolutionary Computing · Computer Science 2018-09-25 C. H. Huck Yang , Rise Ooi , Tom Hiscock , Victor Eguiluz , Jesper Tegnér

Stars and cycles are basic structures in network construction. The former has been well studied in network analysis, while the latter attracted rare attention. A node together with its neighbors constitute a neighborhood star-structure…

Physics and Society · Physics 2019-03-13 Tianlong Fan , Linyuan Lü , Dinghua Shi