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The study of motifs in networks can help researchers uncover links between the structure and function of networks in biology, sociology, economics, and many other areas. Empirical studies of networks have identified feedback loops,…

Physics and Society · Physics 2021-05-12 Alice C. Schwarze , Mason A. Porter

The biological processes of cellular decision making and differentiation involve a plethora of signalling pathways and gene regulatory circuits. These networks, in their turn, exhibit a multitude of motifs playing crucial parts in…

Molecular Networks · Quantitative Biology 2018-05-02 Gustavo Rodrigues Ferreira , Helder Imoto Nakaya , Luciano da Fontoura Costa

Dynamic networks, a.k.a. graph streams, consist of a set of vertices and a collection of timestamped interaction events (i.e., temporal edges) between vertices. Temporal motifs are defined as classes of (small) isomorphic induced subgraphs…

Methodology · Statistics 2022-02-23 Xiaojing Zhu , Eric D. Kolaczyk

Networks are fundamental for our understanding of complex systems. Interactions between individual nodes in networks generate network motifs - small recurrent patterns that can be considered the network's building-block components,…

Dynamical Systems · Mathematics 2022-09-14 Miri Adler , Ruslan Medzhitov

Network motif algorithms have been a topic of research mainly after the 2002-seminal paper from Milo \emph{et al}, that provided motifs as a way to uncover the basic building blocks of most networks. In Bioinformatics, motifs have been…

Data Structures and Algorithms · Computer Science 2013-04-22 Luis A. A. Meira , Vinicius R. Máximo , Álvaro L. Fazenda , Arlindo F. da Conceição

Motifs are thought to be some fundamental components of social face-to-face interaction temporal networks. However, the motifs previously considered are either limited to a handful of nodes and edges, or do not include triangles, which are…

Physics and Society · Physics 2025-05-19 Didier Le Bail

The statistical significance of network properties is conditioned on null models which satisfy spec- ified properties but that are otherwise random. Exponential random graph models are a principled theoretical framework to generate such…

Physics and Society · Physics 2015-11-18 Rico Fischer , Jorge C. Leitao , Tiago P. Peixoto , Eduardo G. Altmann

Network motifs are small building blocks of complex networks. Statistically significant motifs often perform network-specific functions. However, the precise nature of the connection between motifs and the global structure and function of…

Physics and Society · Physics 2015-03-03 Almerima Jamakovic , Priya Mahadevan , Amin Vahdat , Marian Boguna , Dmitri Krioukov

Many recent developments in network analysis have focused on multilayer networks, which one can use to encode time-dependent interactions, multiple types of interactions, and other complications that arise in complex systems. Like their…

Social and Information Networks · Computer Science 2021-01-04 A. Roxana Pamfil , Sam D. Howison , Mason A. Porter

Over the past decade, neural networks have been successful at making predictions from biological sequences, especially in the context of regulatory genomics. As in other fields of deep learning, tools have been devised to extract features…

Genomics · Quantitative Biology 2022-12-27 Antoine Villié , Philippe Veber , Yohann de Castro , Laurent Jacob

The structure of the network can be described by motifs, which are subgraphs that often repeat themselves. In order to understand the structure of network motifs, it is of great importance to study subgraphs from the perspective of…

General Topology · Mathematics 2019-10-25 Ruize Gao , Ying Zhao

Visibility algorithms transform time series into graphs and encode dynamical information in their topology, paving the way for graph-theoretical time series analysis as well as building a bridge between nonlinear dynamics and network…

Data Analysis, Statistics and Probability · Physics 2016-05-11 Jacopo Iacovacci , Lucas Lacasa

Concepts and methods of complex networks can be used to analyse texts at their different complexity levels. Examples of natural language processing (NLP) tasks studied via topological analysis of networks are keyword identification,…

Computation and Language · Computer Science 2017-02-07 Vanessa Queiroz Marinho , Graeme Hirst , Diego Raphael Amancio

Understanding the subgraph distribution in random networks is important for modelling complex systems. In classic Erdos networks, which exhibit a Poissonian degree distribution, the number of appearances of a subgraph G with n nodes and g…

Statistical Mechanics · Physics 2009-11-10 S. Itzkovitz , R. Milo , N. Kashtan , G. Ziv , U. Alon

Network moments--rescaled counts of motifs such as stars and triangles--are fundamental summaries of network structure, widely used in goodness-of-fit testing, model selection, and network comparison. While the univariate distribution of a…

Methodology · Statistics 2026-04-14 Mingyu Qi , Chen-Wei Hua , Tianxi Li , Wen Zhou

Exchangeable random graphs, which include some of the most widely studied network models, have emerged as the mainstay of statistical network analysis in recent years. Graphons, which are the central objects in graph limit theory, provide a…

Statistics Theory · Mathematics 2024-09-17 Anirban Chatterjee , Soham Dan , Bhaswar B. Bhattacharya

Complex networks can often be decomposed into less complex sub-networks whose structures can give hints about the functional organization of the network as a whole. However, these structural motifs can only tell one part of the functional…

Molecular Networks · Quantitative Biology 2015-05-20 Jifeng Qian , Arend Hintze , Christoph Adami

We study complex networks in which the nodes of the network are tagged with different colors depending on the functionality of the nodes (colored graphs), using information theory applied to the distribution of motifs in such networks. We…

Quantitative Methods · Quantitative Biology 2011-11-08 Christoph Adami , Jifeng Qian , Matthew Rupp , Arend Hintze

A network can be analyzed at different topological scales, ranging from single nodes to motifs, communities, up to the complete structure. We propose a novel intermediate-level topological analysis that considers non-overlapping subgraphs…

Computational Physics · Physics 2009-11-13 Lucas Antiqueira , Luciano da Fontoura Costa

Network motifs are overrepresented interconnection patterns found in real-world networks. What functional advantages may they offer for building complex systems? We show that most network motifs emerge from interconnections patterns that…

Systems and Control · Computer Science 2014-11-21 Marco Tulio Angulo , Yang-Yu Liu , Jean-Jacques Slotine
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