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In this paper, we propose a computational framework for 3D volume reconstruction from 2D histological slices using registration algorithms in feature space. To improve the quality of reconstructed 3D volume, first, intensity variations in…

Computer Vision and Pattern Recognition · Computer Science 2009-07-21 Ulas Bagci , Li Bai

Motivation: High resolution 2D whole slide imaging provides rich information about the tissue structure. This information can be a lot richer if these 2D images can be stacked into a 3D tissue volume. A 3D analysis, however, requires…

Intensity-based image registration approaches rely on similarity measures to guide the search for geometric correspondences with high affinity between images. The properties of the used measure are vital for the robustness and accuracy of…

Computer Vision and Pattern Recognition · Computer Science 2019-02-22 Johan Öfverstedt , Joakim Lindblad , Nataša Sladoje

Medical image registration is a difficult problem. Not only a registration algorithm needs to capture both large and small scale image deformations, it also has to deal with global and local image intensity variations. In this paper we…

Computer Vision and Pattern Recognition · Computer Science 2009-07-14 Ulas Bagci , Li Bai

2D to 3D registration is essential in tasks such as diagnosis, surgical navigation, environmental understanding, navigation in robotics, autonomous systems, or augmented reality. In medical imaging, the aim is often to place a 2D image in a…

Computer Vision and Pattern Recognition · Computer Science 2024-10-25 Stefan Brandstätter , Philipp Seeböck , Christoph Fürböck , Svitlana Pochepnia , Helmut Prosch , Georg Langs

Acquisition-to-acquisition signal intensity variations (non-standardness) are inherent in MR images. Standardization is a post processing method for correcting inter-subject intensity variations through transforming all images from the…

Computer Vision and Pattern Recognition · Computer Science 2015-05-18 Ulas Bagci , Jayaram K. Udupa , Li Bai

Recent developments in the registration of histology and micro-computed tomography ({\mu}CT) have broadened the perspective of pathological applications such as virtual histology based on {\mu}CT. This topic remains challenging because of…

In this work, we conducted a survey on different registration algorithms and investigated their suitability for hyperspectral historical image registration applications. After the evaluation of different algorithms, we choose an intensity…

Computer Vision and Pattern Recognition · Computer Science 2017-12-14 AmirAbbas Davari , Tobias Lindenberger , Armin Häberle , Vincent Christlein , Andreas Maier , Christian Riess

Nonlinear registration of 2D histological sections with corresponding slices of MRI data is a critical step of 3D histology reconstruction. This task is difficult due to the large differences in image contrast and resolution, as well as the…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Juan Eugenio Iglesias , Marc Modat , Loic Peter , Allison Stevens , Roberto Annunziata , Tom Vercauteren , Ed Lein , Bruce Fischl , Sebastien Ourselin

Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Our prior work has shown the feasibility of reconstructing 3D brain volumes from 2D…

Image segmentation is to extract meaningful objects from a given image. For degraded images due to occlusions, obscurities or noises, the accuracy of the segmentation result can be severely affected. To alleviate this problem, prior…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Daoping Zhang , Lok Ming Lui

Joint registration of a stack of 2D histological sections to recover 3D structure (``3D histology reconstruction'') finds application in areas such as atlas building and validation of \emph{in vivo} imaging. Straightforward pairwise…

Image and Video Processing · Electrical Eng. & Systems 2021-12-02 Adrià Casamitjana , Marco Lorenzi , Sebastiano Ferraris , Loc Peter , Marc Modat , Allison Stevens , Bruce Fischl , Tom Vercauteren , Juan Eugenio Iglesias

Histological analysis plays a crucial role in understanding tissue structure and pathology. While recent advancements in registration methods have improved 2D histological analysis, they often struggle to preserve critical 3D spatial…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Juming Xiong , Ruining Deng , Jialin Yue , Siqi Lu , Junlin Guo , Marilyn Lionts , Tianyuan Yao , Can Cui , Junchao Zhu , Chongyu Qu , Mengmeng Yin , Haichun Yang , Yuankai Huo

Limited capture range, and the requirement to provide high quality initialization for optimization-based 2D/3D image registration methods, can significantly degrade the performance of 3D image reconstruction and motion compensation…

Computer Vision and Pattern Recognition · Computer Science 2018-01-24 Benjamin Hou , Bishesh Khanal , Amir Alansary , Steven McDonagh , Alice Davidson , Mary Rutherford , Jo V. Hajnal , Daniel Rueckert , Ben Glocker , Bernhard Kainz

We present a 3-step registration pipeline for differently stained histological serial sections that consists of 1) a robust pre-alignment, 2) a parametric registration computed on coarse resolution images, and 3) an accurate nonlinear…

Computer Vision and Pattern Recognition · Computer Science 2019-04-01 Johannes Lotz , Nick Weiss , Stefan Heldmann

Pathologists need to combine information from differently stained pathology slices for accurate diagnosis. Deformable image registration is a necessary technique for fusing multi-modal pathology slices. This paper proposes a hybrid deep…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Chulong Zhang , Yuming Jiang , Na Li , Zhicheng Zhang , Md Tauhidul Islam , Jingjing Dai , Lin Liu , Wenfeng He , Wenjian Qin , Jing Xiong , Yaoqin Xie , Xiaokun Liang

Image synthesis learns a transformation from the intensity features of an input image to yield a different tissue contrast of the output image. This process has been shown to have application in many medical image analysis tasks including…

Computer Vision and Pattern Recognition · Computer Science 2018-12-13 Jacob C. Reinhold , Blake E. Dewey , Aaron Carass , Jerry L. Prince

This paper aims to solve a fundamental problem in intensity-based 2D/3D registration, which concerns the limited capture range and need for very good initialization of state-of-the-art image registration methods. We propose a regression…

Computer Vision and Pattern Recognition · Computer Science 2017-03-07 Benjamin Hou , Amir Alansary , Steven McDonagh , Alice Davidson , Mary Rutherford , Jo V. Hajnal , Daniel Rueckert , Ben Glocker , Bernhard Kainz

Regularization strategies in medical image registration often take a one-size-fits-all approach by imposing uniform constraints across the entire image domain. Yet biological structures are anything but regular. Lacking structural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Ziad Kheil , Soleakhena Ken , Laurent Risser

Synthetic generation of three-dimensional cell models from histopathological images aims to enhance understanding of cell mutation, and progression of cancer, necessary for clinical assessment and optimal treatment. Classical reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2021-02-09 Yoav Alon , Xiang Yu , Huiyu Zhou
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