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The brain is one of the most studied and highly complex systems in the biological world. It is the information center behind all vertebrate and most invertebrate life, and thus has become a major focus in current research. While many of…
Brain research has been driven by enquiry for principles of brain structure organization and its control mechanisms. The neuronal wiring map of C. elegans, the only complete connectome available till date, presents an incredible opportunity…
The nematode Caenorhabditis elegans, with information on neural connectivity, three-dimensional position and cell linage provides a unique system for understanding the development of neural networks. Although C. elegans has been widely…
Control is essential to the functioning of any neural system. Indeed, under healthy conditions the brain must be able to continuously maintain a tight functional control between the system's inputs and outputs. One may therefore hypothesise…
Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function. Here we…
A central problem of neuroscience involves uncovering the principles governing the organization of nervous systems which ensure robustness in brain development. The nematode Caenorhabditis elegans provides us with a model organism for…
Caenorhabditis elegans (C. elegans) illustrated remarkable behavioral plasticities including complex non-associative and associative learning representations. Understanding the principles of such mechanisms presumably leads to constructive…
Motif discovery is a powerful and insightful method to quantify network structures and explore their function. As a case study, we present a comprehensive analysis of regulatory motifs in the connectome of the model organism Caenorhabditis…
The nervous system of the nematode soil worm Caenorhabditis elegans exhibits remarkable complexity despite the worm's small size. A general challenge is to better understand the relationship between neural organization and neural activity…
One of the biggest challenges in biology is to understand how activity at the cellular level of neurons, as a result of their mutual interactions, leads to the observed behavior of an organism responding to a variety of environmental…
The connectome, or the entire connectivity of a neural system represented by network, ranges various scales from synaptic connections between individual neurons to fibre tract connections between brain regions. Although the modularity they…
We exploit flow propagation on the directed neuronal network of the nematode Caenorhabditis elegans to reveal dynamically relevant features of its connectome. We find flow-based groupings of neurons at different levels of granularity, which…
In large neuronal networks, it is believed that functions emerge through the collective behavior of many interconnected neurons. Recently, the development of experimental techniques that allow simultaneous recording of calcium concentration…
We investigate how locomotory behavior is generated in the brain focusing on the paradigmatic connectome of nematode Caenorhabditis elegans (C. elegans) and on neuronal activity patterns that control forward locomotion. We map the neuronal…
A fundamental problem in neuroscience is understanding how a network's properties dictate its function. Connectomics provides one avenue to predict nervous system function. To test this explicitly, we systematically measure signal…
There is renewed interest in modeling and understanding the nervous system of the nematode $\textit{Caenorhabditis elegans}$ ($\textit{C. elegans}$), as this small model system provides a path to bridge the gap between nervous system…
Determining neuronal identity in imaging data is an essential task in neuroscience, facilitating the comparison of neural activity across organisms. Cross-organism comparison, in turn, enables a wide variety of research including…
Complex networks can often be decomposed into less complex sub-networks whose structures can give hints about the functional organization of the network as a whole. However, these structural motifs can only tell one part of the functional…
Probing the developing neural circuitry in Caenorhabditis elegans has enhanced our understanding of nervous systems. The C. elegans connectome, like those of other species, is characterized by a rich club of densely connected neurons…
Recent efforts in neuroscience research seek to obtain detailed anatomical neuronal wiring maps as well as information on how neurons in these networks engage in dynamic activities. Although the entire connectivity map of the nervous system…