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Bacteria are able to maintain a narrow distribution of cell sizes by regulating the timing of cell divisions. In rich nutrient conditions, cells divide much faster than their chromosomes replicate. This implies that cells maintain multiple…

Cell Behavior · Quantitative Biology 2015-07-28 Po-Yi Ho , Ariel Amir

A causal vector autoregressive (CVAR) model is introduced for weakly stationary multivariate processes, combining a recursive directed graphical model for the contemporaneous components and a vector autoregressive model longitudinally.…

In condensed matter physics, simplified descriptions are obtained by coarse-graining the features of a system at a certain characteristic length, defined as the typical length beyond which some properties are no longer correlated. From a…

Genomics · Quantitative Biology 2018-04-18 Ivan Junier , Paul Frémont , Olivier Rivoire

We study causal discovery from a single observed sequence of discrete events generated by a stochastic process, as encountered in vehicle logs, manufacturing systems, or patient trajectories. This regime is particularly challenging due to…

Machine Learning · Computer Science 2026-03-18 Hugo Math , Rainer Lienhart

The general scheme for the treatment of relaxation processes and temporal autocorrelations of dynamical variables for many particle systems is presented in framework of the recurrence relations approach. The time autocorrelation functions…

Statistical Mechanics · Physics 2013-12-10 Anatolii V. Mokshin

Many biological processes are supported by special molecules, called motor proteins or molecular motors, that transport cellular cargoes along linear protein filaments and can reversibly associate to their tracks. Stimulated by these…

Statistical Mechanics · Physics 2021-11-17 Akriti Jindal , Anatoly B. Kolomeisky , Arvind Kumar Gupta

A method is presented that, when used in conjunction with single molecule experimental techniques, allows for the extraction of rates and mechanical properties of a biomolecule undergoing transitions between mechanically distinct states.…

Biomolecules · Quantitative Biology 2009-09-29 Darren E. Segall

Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…

Molecular Networks · Quantitative Biology 2018-06-29 Marieke Lydia Kuijjer , Matthew Tung , GuoCheng Yuan , John Quackenbush , Kimberly Glass

A novel first-order autoregressive moving average model for analyzing discrete-time series observed at irregularly spaced times is introduced. Under Gaussianity, it is established that the model is strictly stationary and ergodic. In the…

Methodology · Statistics 2022-03-31 Cesar Ojeda , Wilfredo Palma , Susana Eyheramendy , Felipe Elorrieta

Single molecule DNA experiments often generate data from force versus extension measurements involving the tethering of a microsphere to one end of a single DNA molecule while the other is attached to a substrate. We show that the…

Biological Physics · Physics 2015-06-26 Jose Coelho Neto , Ronald Dickman , O. N. Mesquita

A random coefficient autoregressive process is deeply investigated in which the coefficients are correlated. First we look at the existence of a strictly stationary causal solution, we give the second-order stationarity conditions and the…

Statistics Theory · Mathematics 2018-03-29 Frédéric Proïa , Marius Soltane

Biochemical processes typically involve huge numbers of individual reversible steps, each with its own dynamical rate constants. For example, kinetic proofreading processes rely upon numerous sequential reactions in order to guarantee the…

Molecular Networks · Quantitative Biology 2009-12-28 Golan Bel , Brian Munsky , Ilya Nemenman

We introduce a deep, generative autoencoder capable of learning hierarchies of distributed representations from data. Successive deep stochastic hidden layers are equipped with autoregressive connections, which enable the model to be…

Machine Learning · Computer Science 2014-05-21 Karol Gregor , Ivo Danihelka , Andriy Mnih , Charles Blundell , Daan Wierstra

Real-world data often exhibits sequential dependence, across diverse domains such as human behavior, medicine, finance, and climate modeling. Probabilistic methods capture the inherent uncertainty associated with prediction in these…

Machine Learning · Statistics 2024-03-08 Alex Boyd

We study the problem of aligning multiple sequences with the goal of finding an alignment that either maximizes the number of aligned symbols (the longest common subsequence (LCS)), or minimizes the number of unaligned symbols (the…

Data Structures and Algorithms · Computer Science 2021-10-26 Debarati Das , Barna Saha

We investigate a recurrent neural network model with common external and bias inputs that can retrieve branching sequences. Retrieval of memory sequences is one of the most important functions of the brain. A lot of research has been done…

Disordered Systems and Neural Networks · Physics 2009-11-13 Kentaro Katahira , Masaki Kawamura , Kazuo Okanoya , Masato Okada

Directed acyclic graphs (DAGs) are a class of graphs commonly used in practice, with examples that include electronic circuits, Bayesian networks, and neural architectures. While many effective encoders exist for DAGs, it remains…

Machine Learning · Computer Science 2025-05-30 Michael Sun , Orion Foo , Gang Liu , Wojciech Matusik , Jie Chen

Boolean networks have been widely used in many areas of science and engineering to represent various dynamical behaviour. In systems biology, they became useful tools to study the dynamical characteristics of large-scale biomolecular…

Dynamical Systems · Mathematics 2024-01-01 Jongrae Kim , Woojeong Lee , Kwang-Hyun Cho

While there has been much interest in adapting conventional clustering procedures---and in higher dimensions, persistent homology methods---to directed networks, little is known about the convergence of such methods. In order to even…

Computational Geometry · Computer Science 2022-12-20 Samir Chowdhury , Facundo Mémoli

Biological systems exhibit processes on a wide range of time and length scales. This work demonstrates that models, wherein the interaction between system constituents is captured by algebraic operations, inherently allow for successive…

Molecular Networks · Quantitative Biology 2019-08-16 Dimitri Loutchko