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We propose a semiparametric framework for causal inference with right-censored survival outcomes and many weak invalid instruments, motivated by Mendelian randomization in biobank studies where classical methods may fail. We adopt an…

Methodology · Statistics 2025-10-06 Qiushi Bu , Wen Su , Xingqiu Zhao , Zhonghua Liu

Inferring treatment effects on a survival time outcome based on data from an observational study is challenging due to the presence of censoring and possible confounding. An additional challenge occurs when a unit's treatment affects the…

Methodology · Statistics 2025-08-13 Chanhwa Lee , Donglin Zeng , Michael Emch , John D. Clemens , Michael G. Hudgens

Most real-world problems that machine learning algorithms are expected to solve face the situation with 1) unknown data distribution; 2) little domain-specific knowledge; and 3) datasets with limited annotation. We propose Non-Parametric…

Machine Learning · Computer Science 2022-09-20 Zhiying Jiang , Yiqin Dai , Ji Xin , Ming Li , Jimmy Lin

Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments in genomics has also adopted these pre-training methods for genome understanding. However, they…

Machine Learning · Computer Science 2022-04-15 Samuel Cahyawijaya , Tiezheng Yu , Zihan Liu , Tiffany T. W. Mak , Xiaopu Zhou , Nancy Y. Ip , Pascale Fung

Breiman (2001) proposed to statisticians awareness of two cultures: 1. Parametric modeling culture, pioneered by R.A.Fisher and Jerzy Neyman; 2. Algorithmic predictive culture, pioneered by machine learning research. Parzen (2001), as a…

Statistics Theory · Mathematics 2012-04-25 Emanuel Parzen , Subhadeep Mukhopadhyay

In this paper, we aim to give a tutorial for undergraduate students studying statistical methods and/or bioinformatics. The students will learn how data visualization can help in genomic sequence analysis. Students start with a fragment of…

Quantitative Methods · Quantitative Biology 2008-01-17 A. N. Gorban , A. Y. Zinovyev

Mainly through regression discontinuity designs, Khanna (2023a) studies the impacts of a primary schooling expansion in India in the 1990s. Absent from the data set are four districts close to the modeled treatment discontinuity.…

General Economics · Economics 2025-11-04 David Roodman

Conformal prediction (CP) is a powerful framework for uncertainty quantification, generating prediction sets with coverage guarantees. Split conformal prediction relies on labeled data in the calibration procedure. However, the labeled data…

Machine Learning · Computer Science 2026-03-11 Xuanning Zhou , Zihao Shi , Hao Zeng , Xiaobo Xia , Bingyi Jing , Hongxin Wei

Practical and ethical constraints often require the use of observational data for causal inference, particularly in medicine and social sciences. Yet, observational datasets are prone to confounding, potentially compromising the validity of…

Machine Learning · Statistics 2026-05-04 Piersilvio De Bartolomeis , Julia Kostin , Javier Abad , Yixin Wang , Fanny Yang

In this paper we propose and study a class of simple, nonparametric, yet interpretable measures of conditional dependence between two random variables $Y$ and $Z$ given a third variable $X$, all taking values in general topological spaces.…

Methodology · Statistics 2022-09-20 Zhen Huang , Nabarun Deb , Bodhisattva Sen

Kernel regression is a popular non-parametric fitting technique. It aims at learning a function which estimates the targets for test inputs as precise as possible. Generally, the function value for a test input is estimated by a weighted…

Machine Learning · Computer Science 2017-12-27 Rongqing Huang , Shiliang Sun

The article tries to compare urban and rural literacy of fifteen selected Indian states during 1981 - 2011 and explores the instruments which can reduce the disparity in urban and rural educational attainment. The study constructs the…

General Economics · Economics 2024-10-10 Sangita Das

It is commonly required to detect change points in sequences of random variables. In the most difficult setting of this problem, change detection must be performed sequentially with new observations being constantly received over time.…

Methodology · Statistics 2015-05-08 Gordon J Ross

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific…

Methodology · Statistics 2026-02-03 Zihang Wang , Razieh Nabi , Benjamin B. Risk

Purpose: To develop and evaluate a semi-supervised learning model for intracranial hemorrhage detection and segmentation on an out-of-distribution head CT evaluation set. Materials and Methods: This retrospective study used semi-supervised…

Image and Video Processing · Electrical Eng. & Systems 2024-04-11 Emily Lin , Esther Yuh

This paper reports a comprehensive study of distributional uncertainty in a few socio-economic indicators across the various states of India over the years 2001-2011. We show that the DGB distribution, a typical rank order distribution,…

Applications · Statistics 2021-02-23 Abhik Ghosh , Olivia Mallick , Souvik Chattopadhay , Banasri Basu

Training deep neural networks usually requires a large amount of labeled data to obtain good performance. However, in medical image analysis, obtaining high-quality labels for the data is laborious and expensive, as accurately annotating…

Computer Vision and Pattern Recognition · Computer Science 2020-05-20 Quande Liu , Lequan Yu , Luyang Luo , Qi Dou , Pheng Ann Heng

Recent research has shown the potential of deep learning in multi-parametric MRI-based visual pathway (VP) segmentation. However, obtaining labeled data for training is laborious and time-consuming. Therefore, it is crucial to develop…

Image and Video Processing · Electrical Eng. & Systems 2024-01-04 Alou Diakite , Cheng Li , Lei Xie , Yuanjing Feng , Hua Han , Shanshan Wang

Interval-censored competing risks data arise when each study subject may experience an event or failure from one of several causes and the failure time is not observed exactly but rather known to lie in an interval between two successive…

Methodology · Statistics 2016-03-02 Lu Mao , D. Y. Lin , Donglin Zeng

We introduce the upward rank mobility curve as a new measure of intergenerational mobility that captures upward movements across the entire parental income distribution. Our approach extends Bhattacharya and Mazumder (2011) by conditioning…

Econometrics · Economics 2025-09-30 Tsung-Chih Lai , Jia-Han Shih , Yi-Hau Chen