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Neurons have the capability of transforming information from a digital signal at the dendrites of the presynaptic termi- nal to an analogous wave at the synaptic cleft and back to a digital pulse when they achieve the required voltage for…

Biological Physics · Physics 2018-10-19 Alexandra Pinto Castellanos

Neural activity fluctuates over a wide range of timescales within and across brain areas. Experimental observations suggest that diverse neural timescales reflect information in dynamic environments. However, how timescales are defined and…

Neurons and Cognition · Quantitative Biology 2026-01-21 Roxana Zeraati , Anna Levina , Jakob H. Macke , Richard Gao

Technological advances have dramatically expanded our ability to probe multi-neuronal dynamics and connectivity in the brain. However, our ability to extract a simple conceptual understanding from complex data is increasingly hampered by…

Neurons and Cognition · Quantitative Biology 2015-03-31 Peiran Gao , Surya Ganguli

The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

Neurons and Cognition · Quantitative Biology 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias

The major problem in information theoretic analysis of neural responses and other biological data is the reliable estimation of entropy--like quantities from small samples. We apply a recently introduced Bayesian entropy estimator to…

Data Analysis, Statistics and Probability · Physics 2009-09-29 Ilya Nemenman , William Bialek , Rob de Ruyter van Steveninck

Neuronal circuits internally regulate electrical signaling via a host of homeostatic mechanisms. Two prominent mechanisms, synaptic scaling and structural plasticity, are believed to maintain average activity within an operating range by…

Neurons and Cognition · Quantitative Biology 2021-04-07 Saeed Aljaberi , Timothy O'Leary , Fulvio Forni

Studies investigating neural information processing often implicitly ask both, which processing strategy out of several alternatives is used and how this strategy is implemented in neural dynamics. A prime example are studies on predictive…

Recent developments in the interfacing of neurons with silicon chips may pave the way for progress in constructing scalable neurocomputers. The assembly of synthetic neuronal networks with predefined synaptic connections and controlled…

Neurons and Cognition · Quantitative Biology 2009-01-16 Nikesh S. Dattani

A central idea in understanding brains and building artificial intelligence is that structure determines function. Yet, how the brain's complex structure arises from a limited set of genetic instructions remains a key question. The ultra…

Neurons and Cognition · Quantitative Biology 2026-01-28 Xingyu Liu , Yubin Li , Guozhang Chen

Here we analyze synaptic transmission from an information-theoretic perspective. We derive closed-form expressions for the lower-bounds on the capacity of a simple model of a cortical synapse under two explicit coding paradigms. Under the…

Neurons and Cognition · Quantitative Biology 2007-05-23 A. Manwani , C. Koch

Spiking activity of neurons engaged in learning and performing a task show complex spatiotemporal dynamics. While the output of recurrent network models can learn to perform various tasks, the possible range of recurrent dynamics that…

Neurons and Cognition · Quantitative Biology 2018-08-21 Christopher Kim , Carson Chow

Neural processes have recently emerged as a class of powerful neural latent variable models that combine the strengths of neural networks and stochastic processes. As they can encode contextual data in the network's function space, they…

Machine Learning · Computer Science 2021-12-03 Jiayi Shen , Xiantong Zhen , Marcel Worring , Ling Shao

Whether, when, and how causal interactions between neurons can be meaningfully studied from observations of neural activity alone are vital questions in neural data analysis. Here we aim to better outline the concept of functional…

Neurons and Cognition · Quantitative Biology 2023-12-05 Ian H. Stevenson

Conceptual and mathematical models of neurons have lagged behind empirical understanding for decades. Here we extend previous work in modeling biological systems with fully scale-independent quantum information-theoretic tools to develop a…

Neurons and Cognition · Quantitative Biology 2022-07-21 Chris Fields , James F. Glazebrook , Michael Levin

Synaptic connections are known to change dynamically. High-frequency presynaptic inputs induce decrease of synaptic weights. This process is known as short-term synaptic depression. The synaptic depression controls a gain for presynaptic…

Disordered Systems and Neural Networks · Physics 2007-05-23 Narihisa Matsumoto , Daisuke Ide , Masataka Watanabe , Masato Okada

Many recent generative models make use of neural networks to transform the probability distribution of a simple low-dimensional noise process into the complex distribution of the data. This raises the question of whether biological networks…

Neural and Evolutionary Computing · Computer Science 2018-02-07 Hesham Mostafa , Gert Cauwenberghs

Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as…

Neurons and Cognition · Quantitative Biology 2013-03-22 Mark Niedringhaus , Xin Chen , Katherine Conant , Rhonda Dzakpasu

Objective: Brain is a fantastic organ that helps creature adapting to the environment. Network is the most essential structure of brain, but the capability of a simple network is still not very clear. In this study, we try to expound some…

Neurons and Cognition · Quantitative Biology 2019-11-05 Xiang Zou , Lie Yao , Donghua Zhao , Liang Chen , Ying Mao

Sequential neuronal activity underlies a wide range of processes in the brain. Neuroscientific evidence for neuronal sequences has been reported in domains as diverse as perception, motor control, speech, spatial navigation and memory.…

Adaptation and Self-Organizing Systems · Physics 2020-04-03 Sascha Frölich , Dimitrije Marković , Stefan J. Kiebel

Here we describe an "information based exchange" model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the…

Neurons and Cognition · Quantitative Biology 2015-09-17 James Kozloski