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Wolbachia is a genus of endosymbiotic bacteria that can infect mosquitoes and reduce their ability to transmit dengue virus. Although the bacterium is transmitted vertically from infected mothers to their offspring, it can be difficult to…

Populations and Evolution · Quantitative Biology 2015-10-06 Ling Xue , Carrie A. Manore , Panpim Thongsripong , James M. Hyman

We develop and analyze an ordinary differential equation model to assess the potential effectiveness of infecting mosquitoes with the Wolbachia bacteria to control the ongoing mosquito-borne epidemics, such as dengue fever, chikungunya, and…

Populations and Evolution · Quantitative Biology 2020-08-14 Zhuolin Qu , Ling Xue , James M. Hyman

We introduce a nonlinear structured population model with diffusion in the state space. Individuals are structured with respect to a continuous variable which represents a pathogen load. The class of uninfected individuals constitutes a…

Analysis of PDEs · Mathematics 2019-03-25 Angel Calsina , Jozsef Z. Farkas

In this paper we study a diffusive age structured epidemic model with disease transmission between vector and host populations. The dynamics of the populations are described by reaction-diffusion equations, with infection age structure of…

Analysis of PDEs · Mathematics 2017-06-15 William E. Fitzgibbon , Jeffrey J. Morgan , Glenn F. Webb , Yixiang Wu

Wolbachia is possibly the most studied reproductive parasite of arthropod species. It appears to be a promising candidate for biocontrol of some mosquito borne diseases. We begin by developing a sex-structured model for a Wolbachia infected…

Populations and Evolution · Quantitative Biology 2019-03-06 József Z. Farkas , Stephen A. Gourley , Rongsong Liu , Abdul-Aziz Yakubu

According to the World Health Organization the global incidence rate of dengue infections have risen drastically in recent years. It is estimated that globally the number of new infections is in the range of $100$ to $400$ million per…

Populations and Evolution · Quantitative Biology 2021-11-09 Jozsef Z. Farkas , Stephen A. Gourley , Rongsong Liu

Wolbachia is a naturally occurring bacterium that can infect Aedes mosquitoes and reduce the transmission of mosquito-borne diseases, including dengue fever, Zika, and chikungunya. Field trials have been conducted worldwide to suppress…

Populations and Evolution · Quantitative Biology 2024-12-02 Zhuolin Qu , Tong Wu

In this paper, Wolbachia infection in a bisexual and diploid population with a fixed cytoplasmic incompatibility rate $w$ and maternal transmission rate $d$ is studied as an evolution algebra. As the cytoplasmic incompatibility (CI) of the…

Rings and Algebras · Mathematics 2024-01-23 Songül Esin , Müge Kanuni , Barış Özdinç

Wolbachia, a maternally transmitted endosymbiont, offers a powerful biological control strategy for mosquito-borne diseases such as dengue, Zika, and malaria. We develop an integro-difference equation (IDE) model that integrates Wolbachia's…

Populations and Evolution · Quantitative Biology 2026-01-27 Zhuolin Qu , Tong Wu , Eddy Kwessi

Arboviral infections, especially dengue, continue to cause significant health burden in their endemic regions. One of the strategies to tackle these infections is to replace the main vector agent, Ae. aegypti, with the ones incapable of…

Populations and Evolution · Quantitative Biology 2019-10-22 Adeshina I. Adekunle , Michael T. Meehan , Emma S. McBryde

We study an infection-age structured epidemic model in which both the infectivity and the rate of loss of immunity depend on the time-since-infection. The model can be equivalently viewed as a nonlinear renewal equation for the incidence of…

Dynamical Systems · Mathematics 2025-11-13 Francesca Scarabel , Harry Coldwell , Tyler Cassidy

Waning immunity and reinfection are critical features of many infectious diseases, but epidemiological models often fail to capture the intricate interaction between an individual's history of immunity and their current infection status;…

Populations and Evolution · Quantitative Biology 2026-03-25 Raimund M. Kovacevic , Nikolaos I. Stilianakis , Vladimir M. Veliov

A compartment epidemic model for infectious disease spreading is investigated, where movement of individuals is governed by spatial diffusion. The model includes infection age of the infected individuals and assumes a logistic growth of the…

Analysis of PDEs · Mathematics 2023-06-28 Christoph Walker

\noindent We formulate an age-structured three-staged nonlinear partial differential equation model that features {\it nonlinear} recidivism to the infected ({\it infectious}) class from the {\it temporarily} recovered class. Equilibria are…

Dynamical Systems · Mathematics 2019-08-07 Fabio Sanchez , Juan G. Calvo , Esteban Segura , Zhilan Feng

Wolbachia are common endosymbionts of terrestrial arthropods, and are also found in nematodes: the animal-parasitic filaria, and the plant-parasite Radopholus similis. Lateral transfer of Wolbachia DNA to the host genome is common. We…

Genomics · Quantitative Biology 2014-01-13 Georgios Koutsovoulos , Benjamin Makepeace , Vincent N. Tanya , Mark Blaxter

This is the first paper in the sequel studying the Wolbachia-infection in bisexual populations. This paper considers the behavior of the population as a discrete dynamical system. The recurrence relation is obtained as a function of the…

Populations and Evolution · Quantitative Biology 2023-02-14 Barış Özdinç , Songül Esin , Müge Kanuni

The release of Wolbachia-infected mosquitoes is a promising strategy for controlling Aedes aegypti populations, but exposure to high temperatures can induce temporary infection loss and compromise long-term persistence. In this work, we…

Populations and Evolution · Quantitative Biology 2026-02-10 Jéssica C. S. Alves , Christian E. Schaerer , Cláudia P. Ferreira

Dynamics of the infectious disease transmission is often best understood taking into account the structure of population with respect to specific features, in example age or immunity level. Practical utility of such models depends on the…

Applications · Statistics 2016-06-21 Piotr Gwiazda , Błażej Miasojedow , Magdalena Rosińska

Structured populations are ubiquitous across the biological sciences. Mathematical models of these populations allow us to understand how individual physiological traits drive the overall dynamics in aggregate. For example, linear age- or…

Analysis of PDEs · Mathematics 2022-04-25 Sabina L. Altus , Jeffrey C. Cameron , David M. Bortz

Wolbachia is a natural bacterium that can infect mosquitoes and reduce their ability to transmit mosquito-borne diseases, such as dengue fever, Zika, and chikungunya. Field trials and modeling studies have shown that the fraction of…

Populations and Evolution · Quantitative Biology 2021-08-25 Zhuolin Qu , Tong Wu , James Mac Hyman
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