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Motivated by recent experiments on intracellular calcium dynamics, we study the general issue of fluctuation-induced nucleation of waves in excitable media. We utilize a stochastic Fitzhugh-Nagumo model for this study, a spatially-extended…

Condensed Matter · Physics 2009-11-10 Herve Henry , Herbert Levine

In these companion papers, we study how the interrelated dynamics of sodium and potassium affect the excitability of neurons, the occurrence of seizures, and the stability of persistent states of activity. In this first paper, we construct…

Neurons and Cognition · Quantitative Biology 2009-09-29 John R. Cressman , Ghanim Ullah , Jokubas Ziburkus , Steven J. Schiff , Ernest Barreto

The FitzHugh-Nagumo equation, originally conceived in neuroscience during the 1960s, became a key model providing a simplified view of excitable neuron cell behavior. Its applicability, however, extends beyond neuroscience into fields like…

Pattern Formation and Solitons · Physics 2025-01-08 Daniel Cebrián-Lacasa , Pedro Parra-Rivas , Daniel Ruiz-Reynés , Lendert Gelens

We investigate feedback control of the cooperative dynamics of two coupled neural oscillators that is induced merely by external noise. The interacting neurons are modelled as FitzHugh-Nagumo systems with parameter values at which no…

Chaotic Dynamics · Physics 2009-11-11 B. Hauschildt , N. B. Janson , A. Balanov , E. Schoell

We study a system of differential equation simulating transport phenomena in active structured media. The model is a generalization of the McKean s modification of the celebrated FitzHugh--Nagumo system, describing the nerve impulse…

Mathematical Physics · Physics 2015-06-11 Wojciech Likus , Vsevolod A. Vladimirov

We study a system of nonlinear differential equations simulating transport phenomena in active media. The model we are interested in is a generalization of the celebrated FitzHugh-Nagumo system, describing the nerve impulse propagation in…

Pattern Formation and Solitons · Physics 2019-05-07 Aleksandra Gawlik , Vsevolod Vladimirov , Sergii Skurativskyi

The Fitzhugh-Nagumo neuronal model is used to explore the influence of the electric field on thermosensitive neurons' dynamics. This study investigates how the electric field affects polarization modulation in cell media induced by changes…

Chaotic Dynamics · Physics 2025-02-13 Ediline L. F. Nguessap , Fernando F. Ferreira , Antonio C. Roque

We investigate a possibility of realization of structurally stable chaotic dynamics in neural systems. The considered model of interacting neurons consists of a pair of coupled FitzHugh-Nagumo systems, with the parameters being periodically…

Chaotic Dynamics · Physics 2017-03-07 Alexey Yu. Jalnine

We study the dynamics of a reaction-diffusion system composed of two mutually coupled excitable fibers. We focus on the situation in which dynamical properties of the two fibers are not identical because of the parameter difference between…

Pattern Formation and Solitons · Physics 2021-01-29 Hiromichi Suetani , Tatsuo Yanagita , Kazuyuki Aihara

In these companion papers, we study how the interrelated dynamics of sodium and potassium affect the excitability of neurons, the occurrence of seizures, and the stability of persistent states of activity. We seek to study these dynamics…

Neurons and Cognition · Quantitative Biology 2009-09-29 Ghanim Ullah , John R. Cressman , Ernest Barreto , Steven J. Schiff

In this paper, we study an excitable, biophysical system that supports wave propagation of nerve impulses. We consider a slow-fast, FitzHugh-Rinzel neuron model where only the membrane voltage interacts diffusively, giving rise to the…

Chaotic Dynamics · Physics 2021-11-03 A. Mondal , A. Mondal , S. Kumar Sharma , R. Kumar Upadhyay , C. G. Antonopoulos

We study the phenomenological model of ensemble of two FitzHugh-Nagumo neuron-like elements with symmetric excitatory couplings. The main advantage of proposed model is the new approach to model of coupling which is implemented by smooth…

Dynamical Systems · Mathematics 2018-12-05 Alexander G. Korotkov , Alexey O. Kazakov , Tatiana A. Levanova , Grigory V. Osipov

The paper studies the excitability properties of a generalized FitzHugh-Nagumo model. The model differs from the purely competitive FitzHugh-Nagumo model in that it accounts for the effect of cooperative gating variables such as activation…

Dynamical Systems · Mathematics 2012-04-26 Alessio Franci , Guillaume Drion , Rodolphe Sepulchre

We study stochastic dynamics of an ensemble of N globally coupled excitable elements. Each element is modeled by a FitzHugh-Nagumo oscillator and is disturbed by independent Gaussian noise. In simulations of the Langevin dynamics we…

Statistical Mechanics · Physics 2009-11-11 M. Zaks , X. Sailer , L. Schimansky-Geier , A. Neiman

We consider the coaction of two distinct noise sources on the activation process of a single and two interacting excitable units, which are mathematically described by the Fitzhugh-Nagumo equations. We determine the most probable activation…

Chaotic Dynamics · Physics 2016-04-19 Igor Franović , Kristina Todorović , Matjaz Perc , Nebojša Vasović , Nikola Burić

In various neurological disorders spatio-temporal excitation patterns constitute examples of excitable behavior emerging from pathological pathways. During migraine, seizure, and stroke an initially localized pathological state can…

Pattern Formation and Solitons · Physics 2007-09-27 Markus A. Dahlem , Felix M. Schneider , Eckehard Schoell

We explore the influence of a block of excitable units on the existence and behavior of chimera states in a nonlocally coupled ring-network of FitzHugh-Nagumo elements. The FitzHugh-Nagumo system, a paradigmatic model in many fields from…

Pattern Formation and Solitons · Physics 2016-03-02 Thomas Isele , Johanne Hizanidis , Astero Provata , Philipp Hövel

The influence of extreme external forcing on traveling-wave dynamics in an ensemble of weakly nonlocally coupled excitable FitzHugh--Nagumo systems is studied. Three types of external exposure are considered: periodic Gaussian pulses,…

Adaptation and Self-Organizing Systems · Physics 2026-05-12 N. I. Semenova , V. V. Semenov , A. V. Bukh

This article communicates results on regular depolarization cascades in periodically-kicked feedforward chains of excitable two-dimensional FitzHugh-Nagumo systems driven by sufficiently strong excitatory forcing at the front node. The…

Dynamical Systems · Mathematics 2021-12-21 B. Ambrosio , S. M. Mintchev

We study the effects of nonlocal control of pulse propagation in excitable media. As a generic example for an excitable medium the FitzHugh-Nagumo model with diffusion in the activator variable is considered. Nonlocal coupling in form of an…

Pattern Formation and Solitons · Physics 2015-06-19 Clemens A. Bachmair , Eckehard Schöll
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