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We apply the theory of markov random fields on trees to derive a phase transition in the number of samples needed in order to reconstruct phylogenies. We consider the Cavender-Farris-Neyman model of evolution on trees, where all the inner…

Probability · Mathematics 2007-05-23 Elchanan Mossel

Tree ensembles, such as random forests and boosted trees, are renowned for their high prediction performance. However, their interpretability is critically limited due to the enormous complexity. In this study, we present a method to make a…

Machine Learning · Statistics 2017-03-01 Satoshi Hara , Kohei Hayashi

Terraces are potentially large sets of trees with precisely the same likelihood or parsimony score, which can be induced by missing sequences in partitioned multi-locus phylogenetic data matrices. The set of trees on a terrace can be…

Populations and Evolution · Quantitative Biology 2014-10-30 Michael J Sanderson , Michelle M. McMahon , Alexandros Stamatakis , Derrick J. Zwickl , Mike Steel

The reconstruction of a species phylogeny from genomic data faces two significant hurdles: 1) the trees describing the evolution of each individual gene--i.e., the gene trees--may differ from the species phylogeny and 2) the molecular…

Machine Learning · Computer Science 2017-07-17 Gautam Dasarathy , Elchanan Mossel , Robert Nowak , Sebastien Roch

Invariants for complicated objects such as those arising in phylogenetics, whether they are invariants as matrices, polynomials, or other mathematical structures, are important tools for distinguishing and working with such objects. In this…

Populations and Evolution · Quantitative Biology 2022-04-06 Joan Carles Pons , Tomás M. Coronado , Michael Hendriksen , Andrew Francis

Bayesian phylogenetic inference is currently done via Markov chain Monte Carlo (MCMC) with simple proposal mechanisms. This hinders exploration efficiency and often requires long runs to deliver accurate posterior estimates. In this paper,…

Machine Learning · Statistics 2024-05-24 Cheng Zhang , Frederick A. Matsen

We present a detailed analysis of the class of regression decision tree algorithms which employ a regulized piecewise-linear node-splitting criterion and have regularized linear models at the leaves. From a theoretic standpoint, based on…

Machine Learning · Computer Science 2019-07-02 Leonidas Lefakis , Oleksandr Zadorozhnyi , Gilles Blanchard

Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.…

Machine Learning · Computer Science 2020-07-02 Abhishek Ghose , Balaraman Ravindran

The probability that two randomly selected phylogenetic trees of the same size are isomorphic is found to be asymptotic to a decreasing exponential modulated by a polynomial factor. The number of symmetrical nodes in a random phylogenetic…

Probability · Mathematics 2009-01-07 Miklos Bona , Philippe Flajolet

Connected acyclic graphs (trees) are data objects that hierarchically organize categories. Collections of trees arise in a diverse variety of fields, including evolutionary biology, public health, machine learning, social sciences and…

Methodology · Statistics 2025-12-01 Maria Alejandra Valdez Cabrera , Amy D Willis , Armeen Taeb

Phylogenetic trees play a key role in the reconstruction of evolutionary relationships. Typically, they are derived from aligned sequence data (like DNA, RNA, or proteins) by using optimization criteria like, e.g., maximum parsimony (MP).…

Populations and Evolution · Quantitative Biology 2025-06-11 Mirko Wilde , Mareike Fischer

Probability estimation is one of the fundamental tasks in statistics and machine learning. However, standard methods for probability estimation on discrete objects do not handle object structure in a satisfactory manner. In this paper, we…

Applications · Statistics 2018-11-06 Cheng Zhang , Frederick A. Matsen

Phylogenetic analyses which include fossils or molecular sequences that are sampled through time require models that allow one sample to be a direct ancestor of another sample. As previously available phylogenetic inference tools assume…

Populations and Evolution · Quantitative Biology 2014-12-08 Alexandra Gavryushkina , David Welch , Tanja Stadler , Alexei Drummond

The maximum parsimony phylogenetic tree reconstruction problem is NP-hard, presenting a computational bottleneck for classical computing and motivating the exploration of emerging paradigms like quantum computing. To this end, we design…

Quantum Physics · Physics 2026-04-20 Jiawei Zhang , Yibo Chen , Yang Zhou , Jun-Han Huang

The so-called binary perfect phylogeny with persistent characters has recently been thoroughly studied in computational biology as it is less restrictive than the well known binary perfect phylogeny. Here, we focus on the notion of (binary)…

Populations and Evolution · Quantitative Biology 2020-03-30 Kristina Wicke , Mareike Fischer

Modelling the substitution of nucleotides along a phylogenetic tree is usually done by a hidden Markov process. This allows to define a distribution of characters at the leaves of the trees and one might be able to obtain polynomial…

Populations and Evolution · Quantitative Biology 2020-10-12 Marta Casanellas , Jesús Fernández-Sánchez , Marina Garrote-López

Probabilistic programming frameworks are powerful tools for statistical modelling and inference. They are not immediately generalisable to phylogenetic problems due to the particular computational properties of the phylogenetic tree object.…

Populations and Evolution · Quantitative Biology 2022-11-11 Christiaan Swanepoel , Mathieu Fourment , Xiang Ji , Hassan Nasif , Marc A Suchard , Frederick A Matsen , Alexei Drummond

Analyzing data collected from multiple sources to estimate common and heterogeneous structures through a hierarchical model is a central task in Bayesian inference, and to this end, Bayesian factor models are one of the most widely used…

Methodology · Statistics 2026-03-04 Naoki Awaya , Keisuke Sasaki , Genya Kobayashi , Shonosuke Sugasawa

Recognizing handwritten mathematics is a challenging classification problem, requiring simultaneous identification of all the symbols comprising an input as well as the complex two-dimensional relationships between symbols and…

Artificial Intelligence · Computer Science 2014-09-19 Scott MacLean , George Labahn

As researchers collect increasingly large molecular data sets to reconstruct the Tree of Life, the heterogeneity of signals in the genomes of diverse organisms poses challenges for traditional phylogenetic analysis. A class of phylogenetic…

Populations and Evolution · Quantitative Biology 2015-09-11 Liang Liu , Zhenxiang Xi , Shaoyuan Wu , Charles Davis , Scott V. Edwards
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