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In this article, a general information-plus-noise transmission model is assumed, the receiver end of which is composed of a large number of sensors and is unaware of the noise pattern. For this model, and under reasonable assumptions, a set…

Information Theory · Computer Science 2015-06-12 Julia Vinogradova , Romain Couillet , Walid Hachem

Collective decision-making arises from individual agents integrating their own personal observations with information obtained from social partners. In many biological systems that exhibit collective decision-making, the process by which…

Quantitative Methods · Quantitative Biology 2026-04-28 Ling-Wei Kong , Naomi Ehrich Leonard , Andrew M. Hein

A biofilm is a microbial city. It consists of bacteria embedded in an extracellular polymeric substance (EPS) that functions as a protective barrier. Quorum sensing (QS) is a method of bacterial communication, where autoinducers (AIs)…

Signal Processing · Electrical Eng. & Systems 2024-08-15 Yanahan Paramalingam , Hamidreza Arjmandi , Freya Harrison , Tara Schiller , Adam Noel

Cellular signaling involves the transmission of environmental information through cascades of stochastic biochemical reactions, inevitably introducing noise that compromises signal fidelity. Each stage of the cascade often takes the form of…

Molecular Networks · Quantitative Biology 2014-08-20 Michael Hinczewski , D. Thirumalai

Eukaryotic cells transmit information by signaling through complex networks of interacting proteins. Here we develop a theoretical and computational framework that relates the biophysics of protein-protein interactions (PPIs) within a…

Molecular Networks · Quantitative Biology 2018-11-26 Ching-Hao Wang , Caleb J. Bashor , Pankaj Mehta

We quantify the influence of the topology of a transcriptional regulatory network on its ability to process environmental signals. By posing the problem in terms of information theory, we may do this without specifying the function…

Molecular Networks · Quantitative Biology 2015-06-26 Etay Ziv , Ilya Nemenman , Chris H. Wiggins

Building on the previous work on interference mitigation, this paper introduces a modular recommender system that automatically selects the most effective interference mitigation strategy based on the interference characteristics present in…

Signal Processing · Electrical Eng. & Systems 2025-12-16 Hiten Prakash Kothari , R. Michael Buehrer

A biofilm is a self-contained community of bacteria that uses signaling molecules called autoinducers (AIs) to coordinate responses through the process of quorum sensing. Biofilms exhibit a dual role that drives interest in both combating…

Cell Behavior · Quantitative Biology 2025-11-07 Yanahan Paramalingam , Adam Noel

This paper studies microfluidic molecular communication receivers with finite-capacity Langmuir adsorption driven by an effective surface concentration. In the reaction-limited regime, we derive a closed-form single-pulse response kernel…

Signal Processing · Electrical Eng. & Systems 2026-01-19 Ruifeng Zheng , Pengjie Zhou , Pit Hofmann , Martín Schottlender , Fatima Rani , Juan A. Cabrera , Frank H. P. Fitzek

Bacteria are able to respond to environmental signals by changing their rules of movement. When we take into account chemical signals in the environment, this behaviour is often called chemotaxis. At the individual-level, chemotaxis…

Analysis of PDEs · Mathematics 2007-05-23 Radek Erban , Hyung Ju Hwang

This paper argues that self-awareness is a learned behavior that emerges in organisms whose brains have a sufficiently integrated, complex ability for associative learning and memory. Continual sensory input of information related to the…

Neurons and Cognition · Quantitative Biology 2007-06-13 Emmanuel Tannenbaum

Bacterial chemotactic sensing converts noisy chemical signals into running and tumbling. We analyze the static sensing limits of mixed Tar/Tsr chemoreceptor clusters in individual Escherichia coli cells using a heterogeneous…

Quantitative Methods · Quantitative Biology 2026-02-24 Ziyi Cui , Sarah Marzen

Signal propagation over long distances is a ubiquitous feature of multicellular communities. In biofilms of the bacterium Bacillus subtilis, we recently discovered that some, but not all, cells participate in the propagation of an…

Biological Physics · Physics 2020-07-01 Xiaoling Zhai , Joseph W. Larkin , Kaito Kikuchi , Samuel E. Redford , Gürol M. Süel , Andrew Mugler

Microbial communities are diverse biological systems that include taxa from across multiple kingdoms of life. Notably, interactions between bacteria and fungi play a significant role in determining community structure. However, these…

Quantitative Methods · Quantitative Biology 2024-04-15 James D. Brunner , Aaron J. Robinson , Patrick S. G. Chain

Bacteria meticulously regulate their intracellular ion concentrations and create ionic concentration gradients across the bacterial membrane. These ionic concentration gradients provide free energy for many cellular processes and are…

Applied Physics · Physics 2022-07-05 Yichao Yang , Hagen Gress , Kamil L. Ekinci

Biological sensory systems react to changes in their surroundings. They are characterized by fast response and slow adaptation to varying environmental cues. Insofar as sensory adaptive systems map environmental changes to changes of their…

Statistical Mechanics · Physics 2014-12-15 Pablo Sartori , Léo Granger , Chiu Fan Lee , Jordan M. Horowitz

Recent technological advances have made it possible to simultaneously measure multiple protein activities at the single cell level. With such data collected under different stimulatory or inhibitory conditions, it is possible to infer the…

Applications · Statistics 2011-08-04 Ruiyan Luo , Hongyu Zhao

This paper addresses the design of transmit precoder and receive combiner matrices to support $N_{\rm s}$ independent data streams over a time-division duplex (TDD) point-to-point massive multiple-input multiple-output (MIMO) channel with…

Information Theory · Computer Science 2024-06-10 Tao Jiang , Wei Yu

In this paper, we propose a novel design for molecular communication in which both the transmitter and the receiver have, in a 3-dimensional environment, multiple bulges (in RF communication this corresponds to antenna). The proposed system…

Emerging Technologies · Computer Science 2016-11-17 Bonhong Koo , H. Birkan Yilmaz , Andrew Eckford , Chan-Byoung Chae

A poorly understood step in the transition from a chemical to a biological world is the emergence of self-replicating molecular systems. We study how a precursor for such a replicator might arise in a hydrothermal RNA reactor, which…

Biomolecules · Quantitative Biology 2011-06-30 B. Obermayer , H. Krammer , D. Braun , U. Gerland