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Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility…

Biomolecules · Quantitative Biology 2024-12-30 Damiano Sgarbossa , Umberto Lupo , Anne-Florence Bitbol

DNA storage technology offers new possibilities for addressing massive data storage due to its high storage density, long-term preservation, low maintenance cost, and compact size. To improve the reliability of stored information, base…

Machine Learning · Computer Science 2024-09-24 Bowen Liu , Jiankun Li

When the exact probability distribution of input conditions cannot be obtained in practical engineering problems, interval analysis methods are often used to analyze the upper and lower bounds of output responses. Essentially, this can be…

Neural and Evolutionary Computing · Computer Science 2024-10-10 Xuanlong Wu , Peng Zhong , Weihao Lin

A hypercomplex representation of DNA is proposed to facilitate comparison of DNA sequences with fuzzy composition. Using hypercomplex number representation, conventional sequence analysis method, such as, dot matrix analysis, dynamic…

Quantitative Methods · Quantitative Biology 2023-08-03 Jian-Jun Shu , Yajing Li

A standard approach to solving the S$_N$ transport equations is to use source iteration with diffusion synthetic acceleration (DSA). Although this approach is widely used and effective on many problems, there remain some practical issues…

Numerical Analysis · Mathematics 2020-07-22 Ben S. Southworth , Milan Holec , Terry S. Haut

State-space models (SSMs) have recently attention as an efficient alternative to computationally expensive attention-based models for sequence modeling. They rely on linear recurrences to integrate information over time, enabling fast…

Machine Learning · Computer Science 2026-01-01 Mahdi Karami , Ali Behrouz , Peilin Zhong , Razvan Pascanu , Vahab Mirrokni

Domain shift happens in cross-domain scenarios commonly because of the wide gaps between different domains: when applying a deep learning model well-trained in one domain to another target domain, the model usually performs poorly. To…

Computer Vision and Pattern Recognition · Computer Science 2021-08-19 Munan Ning , Cheng Bian , Dong Wei , Chenglang Yuan , Yaohua Wang , Yang Guo , Kai Ma , Yefeng Zheng

Time series data, including univariate and multivariate ones, are characterized by unique composition and complex multi-scale temporal variations. They often require special consideration of decomposition and multi-scale modeling to…

Machine Learning · Computer Science 2024-03-26 Shuhan Zhong , Sizhe Song , Weipeng Zhuo , Guanyao Li , Yang Liu , S. -H. Gary Chan

Mining dense subgraphs where vertices connect closely with each other is a common task when analyzing graphs. A very popular notion in subgraph analysis is core decomposition. Recently, Esfahani et al. presented a probabilistic core…

Machine Learning · Statistics 2023-03-29 Yang Guo , Xuekui Zhang , Fatemeh Esfahani , Venkatesh Srinivasan , Alex Thomo , Li Xing

Summary: BWA-MEM is a new alignment algorithm for aligning sequence reads or long query sequences against a large reference genome such as human. It automatically chooses between local and end-to-end alignments, supports paired-end reads…

Genomics · Quantitative Biology 2013-05-28 Heng Li

We present the MSA-to-protein transformer, a generative model of protein sequences conditioned on protein families represented by multiple sequence alignments (MSAs). Unlike existing approaches to learning generative models of protein…

Biomolecules · Quantitative Biology 2022-04-05 Soumya Ram , Tristan Bepler

We consider the problem of person search in unconstrained scene images. Existing methods usually focus on improving the person detection accuracy to mitigate negative effects imposed by misalignment, mis-detections, and false alarms…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Xu Lan , Xiatian Zhu , Shaogang Gong

In this paper, we introduce a new domain adaptation (DA) algorithm where the source and target domains are represented by subspaces spanned by eigenvectors. Our method seeks a domain invariant feature space by learning a mapping function…

Computer Vision and Pattern Recognition · Computer Science 2014-10-24 Basura Fernando , Amaury Habrard , Marc Sebban , Tinne Tuytelaars

Feature alignment between domains is one of the mainstream methods for Unsupervised Domain Adaptation (UDA) semantic segmentation. Existing feature alignment methods for semantic segmentation learn domain-invariant features by adversarial…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Shuang Wang , Dong Zhao , Yi Li , Chi Zhang , Yuwei Guo , Qi Zang , Biao Hou , Licheng Jiao

The supervised training of deep networks for semantic segmentation requires a huge amount of labeled real world data. To solve this issue, a commonly exploited workaround is to use synthetic data for training, but deep networks show a…

Computer Vision and Pattern Recognition · Computer Science 2020-03-13 Marco Toldo , Umberto Michieli , Gianluca Agresti , Pietro Zanuttigh

The inability to resolve deep node relationships of highly divergent/rapidly evolving protein families is a major factor that stymies evolutionary studies. In this manuscript, we propose a Multiple Sequence Alignment (MSA) independent…

Empirically observed time series in physics, biology, or medicine, are commonly generated by some underlying dynamical system (DS) which is the target of scientific interest. There is an increasing interest to harvest machine learning…

Machine Learning · Computer Science 2022-07-07 Daniel Kramer , Philine Lou Bommer , Carlo Tombolini , Georgia Koppe , Daniel Durstewitz

The rapid development of high-throughput sequencing technologies has led to an explosive increase in biological sequence data, making sequence clustering a fundamental task in large-scale bioinformatics analyses. Unlike traditional…

Genomics · Quantitative Biology 2026-01-22 Simeng Zhang , Xinying Liu , Jun Lou , Mudi Jiang , Quan Zou , Zengyou He

Multi-source domain adaptation (DA) aims at leveraging information from more than one source domain to make predictions in a target domain, where different domains may have different data distributions. Most existing methods for…

Machine Learning · Statistics 2023-12-12 Yujie Wu , Giovanni Parmigiani , Boyu Ren

High-dimensional data requires scalable algorithms. We propose and analyze three scalable and related algorithms for semi-supervised discriminant analysis (SDA). These methods are based on Krylov subspace methods which exploit the data…

Artificial Intelligence · Computer Science 2019-02-21 Joris Tavernier , Jaak Simm , Karl Meerbergen , Joerg Kurt Wegner , Hugo Ceulemans , Yves Moreau