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Post-transductional modifications tune the functions of proteins and regulate the collective dynamics of biochemical networks that determine how cells respond to environmental signals. For example, protein phosphorylation and nitrosylation…

Cell Behavior · Quantitative Biology 2009-11-13 Roberto Chignola , Chiara Dalla Pellegrina , Alessio Del Fabbro , Edoardo Milotti

In elastic-wave turbulence, strong turbulence appears in small wave numbers while weak turbulence does in large wave numbers. Energy transfers in the coexistence of these turbulent states are numerically investigated in both of the Fourier…

Fluid Dynamics · Physics 2017-08-28 Naoto Yokoyama , Masanori Takaoka

We provide a detailed multiscale analysis of a system of particles interacting through a dynamical network of links. Starting from a microscopic model, via the mean field limit, we formally derive coupled kinetic equations for the particle…

Analysis of PDEs · Mathematics 2016-07-14 Julien Barré , Pierre Degond , Ewelina Zatorska

Across all scales of the physical world, dynamical systems can often be usefully represented as abstract networks that encode the system's units and inter-unit interactions. Understanding how physical rules shape the topological structure…

Mesoscale and Nanoscale Physics · Physics 2023-11-28 Abigail N. Poteshman , Mathieu Ouellet , Lee C. Bassett , Danielle S. Bassett

We introduce a solvable model of a nonlinear double-barrier structure, described by a generalized effective-mass equation with a nonlinear coupling term. This model is interesting in its own right for possible new applications, as well as…

Condensed Matter · Physics 2007-05-23 E. Diez , A. Sanchez , F. Dominguez-Adame

Mechanical stresses are increasingly found to be associated with various biological functionalities. At the same time, topological defects are being identified across a diverse range of biological systems and are points of localized…

Soft Condensed Matter · Physics 2023-12-08 Lasse Bonn , Aleksandra Ardaševa , Amin Doostmohammadi

Deploying deep learning models, comprising of non-linear combination of millions, even billions, of parameters is challenging given the memory, power and compute constraints of the real world. This situation has led to research into model…

Machine Learning · Computer Science 2020-05-29 Muhammad A. Shah , Raphael Olivier , Bhiksha Raj

We study the identifiability of nonlinear network systems with partial excitation and partial measurement when the network dynamics is linear on the edges and nonlinear on the nodes. We assume that the graph topology and the nonlinear…

Optimization and Control · Mathematics 2025-05-21 Martina Vanelli , Julien M. Hendrickx

Link failures repeatedly induce large-scale outages in power grids and other supply networks. Yet, it is still not well understood, which links are particularly prone to inducing such outages. Here we analyze how the nature and location of…

Physics and Society · Physics 2016-04-06 Dirk Witthaut , Martin Rohden , Xiaozhu Zhang , Sarah Hallerberg , Marc Timme

We study the effect of disorder on the particle density evolution in a classical Hamiltonian driven lattice setup. If the disorder is localized within a finite sub-domain of the lattice, the emergence of strong tails in the density…

Chaotic Dynamics · Physics 2016-09-21 Thomas Wulf , Alexander Okupnik , Peter Schmelcher

The folding pathway and rate coefficients of the folding of a knotted protein are calculated for a potential energy function with minimal energetic frustration. A kinetic transition network is constructed using the discrete path sampling…

Biomolecules · Quantitative Biology 2010-07-05 Michael C. Prentiss , David J. Wales , Peter G. Wolynes

The classical approach to protein folding inspired by statistical mechanics avoids the high dimensional structure of the conformation space by using effective coordinates. Here we introduce a network approach to capture the statistical…

Biomolecules · Quantitative Biology 2007-05-23 Erzsebet Ravasz , S. Gnanakaran , Zoltan Toroczkai

We define a characteristic energy density based on the measurement of the two first moments of the extrinsic injected power smoothed over time. Using the stationarity, we show that this definition characterizes an energy per degrees freedom…

Statistical Mechanics · Physics 2018-07-06 Sebastien Aumaitre , Antoine Naert

A long standing puzzle in the rheology of living cells is the origin of the experimentally observed long time stress relaxation. The mechanics of the cell is largely dictated by the cytoskeleton, which is a biopolymer network consisting of…

Biological Physics · Physics 2021-10-04 Sihan Chen , Chase P. Broedersz , Tomer Markovich , Fred C. MacKintosh

We propose some kinetic models of wealth exchange and investigate their behavior on directed networks though numerical simulations. We observe that network topology and directedness yields a variety of interesting features in these models.…

Physics and Society · Physics 2009-11-13 Arnab Chatterjee

Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. The motor exhibits distinct states of motility: active motion along filaments, and…

Biological Physics · Physics 2016-11-29 Anne E. Hafner , Ludger Santen , Heiko Rieger , M. Reza Shaebani

We study effects of weak nonlineary on localization of waves in disordered Stark ladder corresponding to propagation in presence of disorder and a static field. Our numerical results show that nonlinearity leads to delocalization with…

Disordered Systems and Neural Networks · Physics 2009-10-01 Ignacio Garcia-Mata , Dima L. Shepelyansky

The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and metabolic networks. All these networks are highly dynamic…

Molecular Networks · Quantitative Biology 2007-07-26 Mate S. Szalay , Istvan A. Kovacs , Tamas Korcsmaros , Csaba Bode , Peter Csermely

The theory of pattern formation in reaction-diffusion systems is extended to the case of a directed network. Due to the structure of the network Laplacian of the scrutinised system, the dispersion relation has both real and imaginary parts,…

Pattern Formation and Solitons · Physics 2014-08-01 Malbor Asllani , Joseph D. Challenger , Francesco Saverio Pavone , Leonardo Sacconi , Duccio Fanelli

Link weight is crucial in weighted complex networks. It provides additional dimension for describing and adjusting the properties of networks. The topological role of weight is studied by the effects of random redistribution of link weights…

Statistical Mechanics · Physics 2007-05-23 Menghui Li , Ying Fan , Dahui Wang , Na Liu , Daqing Li , Jinshan Wu , Zengru Di
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