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Module network inference is an established statistical method to reconstruct co-expression modules and their upstream regulatory programs from integrated multi-omics datasets measuring the activity levels of various cellular components…

Genomics · Quantitative Biology 2015-05-20 Eric Bonnet , Laurence Calzone , Tom Michoel

We developed a novel reservoir characterization workflow that addresses reservoir history matching by coupling a physics-informed neural operator (PINO) forward model with a mixture of experts' approach, termed cluster classify regress…

Machine Learning · Computer Science 2024-06-05 Clement Etienam , Yang Juntao , Oleg Ovcharenko , Issam Said

Group-relative reinforcement learning with verifiable rewards (RLVR) often wastes the most informative data it already has the failures. When all rollouts are wrong, gradients stall; when one happens to be correct, the update usually…

Machine Learning · Computer Science 2026-03-17 Yongxin Wang , Zhicheng Yang , Meng Cao , Mingfei Han , Haokun Lin , Yingying Zhu , Xiaojun Chang , Xiaodan Liang

Lane detection plays a crucial role in autonomous driving by providing vital data to ensure safe navigation. Modern algorithms rely on anchor-based detectors, which are then followed by a label-assignment process to categorize training…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Sapir Kontente , Roy Orfaig , Ben-Zion Bobrovsky

Inverse problems are pervasive mathematical methods in inferring knowledge from observational and experimental data by leveraging simulations and models. Unlike direct inference methods, inverse problem approaches typically require many…

Computational Physics · Physics 2019-12-20 Sheroze Sheriffdeen , Jean C. Ragusa , Jim E. Morel , Marvin L. Adams , Tan Bui-Thanh

Casing collar locator (CCL) measurements are widely used as reliable depth markers for positioning downhole instruments in cased-hole operations, enabling accurate depth control for operations such as perforation. However, autonomous collar…

Systems and Control · Electrical Eng. & Systems 2026-03-04 Si-Yu Xiao , Xin-Di Zhao , Xiang-Zhan Wang , Tian-Hao Mao , Ying-Kai Liao , Xing-Yu Liao , Yu-Qiao Chen , Jun-Jie Wang , Shuang Liu , Tu-Pei Chen , Yang Liu

Learning-based methods have demonstrated remarkable performance in solving inverse problems, particularly in image reconstruction tasks. Despite their success, these approaches often lack theoretical guarantees, which are crucial in…

Numerical Analysis · Mathematics 2025-10-21 Clemens Arndt , Judith Nickel

Effective biomedical literature retrieval (BLR) plays a central role in precision medicine informatics. In this paper, we propose GRAPHENE, which is a deep learning based framework for precise BLR. GRAPHENE consists of three main different…

Information Retrieval · Computer Science 2019-11-22 Sendong Zhao , Chang Su , Andrea Sboner , Fei Wang

Channel state information (CSI) is very crucial for any wireless communication systems. Typically, CSI can be characterized at the receiver side using channel impulse response (CIR). Many observations have shown that the CIR of broadband…

Signal Processing · Electrical Eng. & Systems 2018-12-12 Ahmed M. Abd El-Moaty , Azzedine Zerguine

This paper argues that the judicial use of formal language theory and grammatical inference are invaluable tools in understanding how deep neural networks can and cannot represent and learn long-term dependencies in temporal sequences.…

Computation and Language · Computer Science 2017-10-17 Enes Avcu , Chihiro Shibata , Jeffrey Heinz

The relationship between the design and functionality of molecular networks is now a key issue in biology. Comparison of regulatory networks performing similar tasks can give insights into how network architecture is constrained by the…

Molecular Networks · Quantitative Biology 2015-06-26 Ala Trusina , Kim Sneppen , Ian B. Dodd , Keith E. Shearwin , J. Barry Egan

Gene regulatory network inference is crucial for understanding the complex molecular interactions in various genetic and environmental conditions. The rapid development of single-cell RNA sequencing (scRNA-seq) technologies unprecedentedly…

Methodology · Statistics 2021-11-09 Feiyi Xiao , Junjie Tang , Huaying Fang , Ruibin Xi

This study examines whether Low-Rank Adaptation (LoRA) fine-tuned Large Language Models (LLMs) can approximate the performance of fully fine-tuned models in generating human-interpretable decisions and explanations for malware…

Cryptography and Security · Computer Science 2025-11-26 Stephen C. Gravereaux , Sheikh Rabiul Islam

Current Large Language Models (LLMs) face three major challenges: context length limitations, high inference costs, and catastrophic forgetting during continual learning. While Mixture-of-Experts (MoE) architectures mitigate some of these…

Machine Learning · Computer Science 2025-12-23 Zhongpan Tang

While Large Language Models (LLMs) demonstrate increasingly sophisticated affective capabilities, the internal mechanisms by which they process complex emotions remain unclear. Existing interpretability approaches often treat models as…

Computation and Language · Computer Science 2026-04-23 Yitong Shou , Manhao Guan

Large Language Models (LLMs) have recently demonstrated remarkable performance in various Natural Language Processing (NLP) applications, such as sentiment analysis, content generation, and personalized recommendations. Despite their…

Computation and Language · Computer Science 2024-12-10 Mahaman Sanoussi Yahaya Alassan , Jessica López Espejel , Merieme Bouhandi , Walid Dahhane , El Hassane Ettifouri

The development of Multimodal Virtual Agents has made significant progress through the integration of Multimodal Large Language Models. However, mainstream training paradigms face key challenges: Behavior Cloning is simple and effective…

Machine Learning · Computer Science 2026-01-06 Keyu Wang , Bingchen Miao , Wendong Bu , Yu Wu , Juncheng Li , Shengyu Zhang , Wenqiao Zhang , Siliang Tang , Jun Xiao , Yueting Zhuang

Cellular Simultaneous Recurrent Neural Network (SRN) has been shown to be a function approximator more powerful than the MLP. This means that the complexity of MLP would be prohibitively large for some problems while SRN could realize the…

Neural and Evolutionary Computing · Computer Science 2007-10-24 Roman Ilin , Robert Kozma , Paul J. Werbos

We present a comparative analysis of large-scale topological and evolutionary properties of transcription networks in three species, the two distant bacteria E. coli and B. subtilis, and the yeast S. cerevisiae. The study focuses on the…

Molecular Networks · Quantitative Biology 2008-05-16 A. L. Sellerio , B. Bassetti , H. Isambert , M. Cosentino Lagomarsino

Predicting the impact of genomic and drug perturbations in cellular function is crucial for understanding gene functions and drug effects, ultimately leading to improved therapies. To this end, Causal Representation Learning (CRL)…

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