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We present a numerical study of the effect of knotting on the ejection of flexible and semiflexible polymers from a spherical, virus-like capsid. The polymer ejection rate is primarily controlled by the knot, which moves to the hole in the…

Biomolecules · Quantitative Biology 2009-02-23 R Matthews , A. A. Louis , J. M. Yeomans

We examine the ejection of an initially strongly confined flexible polymer from a spherical capsid through a nanoscale pore. We use molecular dynamics for unprecedentedly high initial monomer densities. We show that the time for an…

Biological Physics · Physics 2016-01-06 J. Piili , R. P. Linna

While the dynamics of a fully flexible polymer ejecting a capsid through a nanopore has been extensively studied, the ejection dynamics of semiflexible polymers has not been properly characterized. Here we report results from simulations of…

Biological Physics · Physics 2017-11-08 Riku P. Linna , Pauli M. Suhonen , Joonas Piili

Polymer ejection from a capsid through a nanoscale pore is an important biological process with relevance to modern biotechnology. Here, we study generic capsid ejection using Langevin dynamics. We show that even when the ejection takes…

Biological Physics · Physics 2014-05-09 R. P. Linna , J. E. Moisio , P. M. Suhonen , K. Kaski

We study the dynamics of a knot in a semiflexible polymer confined to a narrow channel of width comparable to the polymers' persistence length. Using a combination of Brownian dynamics simulations and a coarse-grained stochastic model, we…

Soft Condensed Matter · Physics 2008-08-14 Wolfram Mobius , Erwin Frey , Ulrich Gerland

The statistical mechanics of a long knotted collapsed polymer is determined by a free-energy with a knot-dependent subleading term, which is linked to the length of the shortest polymer that can hold such knot. The only other parameter…

Statistical Mechanics · Physics 2014-12-01 Marco Baiesi , Enzo Orlandini , Attilio L. Stella

Reptation governs motion of long polymers through a confining environment. Slack enters at the ends and diffuses along the polymer as stored length. The rate at which stored length diffuses limits the speed at which the chain can drift.…

Soft Condensed Matter · Physics 2015-06-25 M. Widom , I. Al-Lehyani

The interplay of topological constraints and Coulomb interactions in static and dynamic properties of charged polymers is investigated by numerical simulations and scaling arguments. In the absence of screening, the long-range interaction…

Statistical Mechanics · Physics 2009-11-07 Paul G. Dommersnes , Yacov Kantor , Mehran Kardar

Scaling arguments are used to analyze the size of topologically constrained closed ring polymer with excluded volume. It is found that there exists a finite range of polymer thickness (excluded volume) in which self-avoidance is unimportant…

Soft Condensed Matter · Physics 2007-05-23 A. Yu. Grosberg

We consider the diffusive motion of a localized knot along a linear polymer chain. In particular, we derive the mean diffusion time of the knot before it escapes from the chain once it gets close to one of the chain ends. Self-reptation of…

Soft Condensed Matter · Physics 2009-11-11 Ralf Metzler , Walter Reisner , Robert Riehn , Robert Austin , Jonas Tegenfeldt , Igor M. Sokolov

The rate of escape of polymers from a two-dimensionally confining potential well has been evaluated using self-avoiding as well as ideal chain representations of varying length, up to 80 beads. Long timescale Langevin trajectories were…

Soft Condensed Matter · Physics 2015-03-27 Harri Mökkönen , Timo Ikonen , Tapio Ala-Nissila , Hannes Jónsson

We analyze the motion of individual beads of a polymer chain using a discrete version of De Gennes' reptation model that describes the motion of a polymer through an ordered lattice of obstacles. The motion within the tube can be evaluated…

Soft Condensed Matter · Physics 2016-08-15 U. Ebert , L. Schäfer , A. Baumgärtner

We develop a theoretical description of the topological disentanglement occurring when torus knots reach the ends of a semi-flexible polymer under tension. These include decays into simpler knots and total unknotting. The minimal number of…

Statistical Mechanics · Physics 2020-11-04 Michele Caraglio , Boris Marcone , Fulvio Baldovin , Enzo Orlandini , Attilio L. Stella

We report molecular dynamics simulations of a system of repulsive, polymer-tethered colloidal particles. We use an explicit polymer model to explore how the length and the behavior of the polymer (ideal or self-avoiding) affect the ability…

Soft Condensed Matter · Physics 2015-05-14 Behnaz Bozorgui , Maya Sen , William L. Miller , Josep C. Pamies , Angelo Cacciuto

The viscous flow of polymer chains in dense melts is dominated by topological constraints whenever the single chain contour length, N, becomes larger than the characteristic scale Ne, defining comprehensively the macroscopic rheological…

Soft Condensed Matter · Physics 2023-07-19 Mattia Alberto Ubertini , Angelo Rosa

Knotted proteins, when forced through the pores, can get stuck if the knots in their backbone tighten under force. Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model…

Statistical Mechanics · Physics 2023-11-08 Karol Capała , Piotr Szymczak

Translocation of a polymer out of curved surface or membrane is studied via mean first passage time approach. Membrane curvature gives rise to a constraint on polymer conformation, which effectively drives the polymer to the outside of…

Soft Condensed Matter · Physics 2009-10-31 Pyeong Jun Park , Wokyung Sung

Semi-flexible polymers in crowded environments exhibit complex dynamics that play a crucial role in various biological and material design processes. Based on the classic reptation theory, it is generally believed that semiflexible polymers…

Soft Condensed Matter · Physics 2023-05-05 Ahmad Reza Motezakker , Andrés Córdoba , Tomas Rosén , Fredrik Lundell , L. Daniel Söderberg

In this paper, we present a new approach to the Kratky-Porod Model (KP) of semiflexible polymers. Our solution to the model is based on the definition of a generating function which we use to study the statistical mechanics of semiflexible…

Statistical Mechanics · Physics 2007-05-23 Marcelo Marucho , Leonardo Loureiro , Gustavo A. Carri

The Knot Entropy Conjecture states that the exponential growth rate of the number of $n$-edge lattice polygons with knot-type $K$ is the same as that for unknot polygons. Moreover, the next order growth follows a power law in $n$ with an…

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