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We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept of Misrepair and the concept of accumulation of Misrepairs.…

Tissues and Organs · Quantitative Biology 2017-01-04 Jicun Wang-Michelitsch , Thomas Michelitsch

Why life is complex and --most importantly-- what is the origin of the over abundance of complexity in nature? This is a fundamental scientific question which, paraphrasing the late Per Bak, "is screaming to be answered but seldom is even…

Other Quantitative Biology · Quantitative Biology 2019-01-30 Dante R. Chialvo

The scientific study of the retina has reached a remarkable state of completion. We can now explain many aspects of early visual processing based on a relatively simple model of neural circuitry in the retina. The same model, with different…

Neurons and Cognition · Quantitative Biology 2025-10-22 Markus Meister

The paper introduces a biologically and evolutionarily plausible neural architecture that allows a single group of neurons, or an entire cortical pathway, to be dynamically reconfigured to perform multiple, potentially very different…

Neural and Evolutionary Computing · Computer Science 2015-08-13 Thomas M. Breuel

Like students facing hard exam questions, large language models sometimes guess when uncertain, producing plausible yet incorrect statements instead of admitting uncertainty. Such "hallucinations" persist even in state-of-the-art systems…

Computation and Language · Computer Science 2025-09-08 Adam Tauman Kalai , Ofir Nachum , Santosh S. Vempala , Edwin Zhang

Statistical mechanics determines the abundance of different arrangements of matter depending on cost-benefit balances. Its formalism and phenomenology percolate throughout biological processes and set limits to effective computation. Under…

Neurons and Cognition · Quantitative Biology 2021-02-03 Luís F Seoane

The famous claim that we only use about 10% of the brain capacity has recently been challenged. Researchers argue that we are likely to use the whole brain, against the 10% claim. Some evidence and results from relevant studies and…

Neurons and Cognition · Quantitative Biology 2016-02-01 Chenxia Gu , Shaotong Wang , Hao Yu

The spiking activity of the hippocampal place cells plays a key role in producing and sustaining an internalized representation of the ambient space---a cognitive map. These cells do not only exhibit location-specific spiking during…

Neurons and Cognition · Quantitative Biology 2018-11-05 Andrey Babichev , Dmitriy Morozov , Yuri Dabaghian

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

`Bursting', defined as periods of high frequency firing of a neuron separated by periods of quiescence, has been observed in various neuronal systems, both \textit{in vitro} and \textit{in vivo}. It has been associated with a range of…

Neurons and Cognition · Quantitative Biology 2018-06-20 E. Cotterill , S. J. Eglen

The dynamic instability of the living systems and the "superposition" of different forms of randomness are viewed as a component of the contingently increasing organization of life along evolution. We briefly survey how classical and…

Other Quantitative Biology · Quantitative Biology 2011-04-07 Marcello Buiatti , Giuseppe Longo

Free will is an old philosophical enigma that has been recently revived by neuropsychology. We restrict ourselves to the problem that determinism seems to allow only an illusion of freedom but random decissions do not contain any freedom…

Classical Physics · Physics 2007-05-23 Petr Hajicek

In this paper, we will argue that if we want to understand the function of the brain (or the control in the case of robots), we must understand how the brain is embedded into the physical system, and how the organism interacts with the real…

Artificial Intelligence · Computer Science 2012-02-03 Matej Hoffmann , Rolf Pfeifer

Computers are a very important part of our lives and the major reason why they have been such a success is because of the excellent graphical operating systems that run on these powerful machines. As the computer hardware is becoming more…

Operating Systems · Computer Science 2012-05-30 Plawan Kumar Rath , G. N. Anil

Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in…

Neurons and Cognition · Quantitative Biology 2020-10-06 Richard Betzel

At any moment in time, evolution is faced with a formidable challenge: refining the already highly optimised design of biological species, a feat accomplished through all preceding generations. In such a scenario, the impact of random…

Populations and Evolution · Quantitative Biology 2024-02-20 Alessandro Fontana , Marios Kyriazis

Global brain activity self-organizes into discrete patterns characterized by distinct behavioral observables and modes of information processing. The human thalamocortical system is a densely connected network where local neural activation…

Despite the fact that the phenomenon of bursting activity is important for functioning of living neural networks, the mechanisms of its origin are still not clear. In this paper, we propose a new phenomenological model that can explain the…

Neurons and Cognition · Quantitative Biology 2023-03-01 Nikita Barabash , Tatiana Levanova , Sergey Stasenko

(1) Background: Tinnitus is the perception of phantom sound in the absence of a corresponding external source. Previous studies reported that the presence of tinnitus is notably absent during dreams. This study aimed at replicating previous…

Neurons and Cognition · Quantitative Biology 2025-04-03 Robin Guillard , Nicolas Dauman , Aurélien Cadix , Charlotte Glabasnia Linck , Marco Congedo , Dirk de Ridder , Alain Londero

How subjective experience (i.e., consciousness) arises out of objective material processes has been called the hard problem. The neuroscience of consciousness has set out to find the sufficient conditions for consciousness and theoretical…

Neurons and Cognition · Quantitative Biology 2023-11-17 Peter Coppola
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