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This work is the first attempt to treat partial differential equations with discrete (concentrated) state-dependent delay. The main idea is to approximate the discrete delay term by a sequence of distributed delay terms (all with…

Dynamical Systems · Mathematics 2009-04-18 Alexander V. Rezounenko

We consider abstract evolution equations with a nonlinear term depending on the state and on delayed states. We show that, if the $C_0$-semigroup describing the linear part of the model is exponentially stable, then the whole system retains…

Analysis of PDEs · Mathematics 2017-05-11 Serge Nicaise , Cristina Pignotti

In this paper, we explore the solvability and the optimal control problem for a compartmental model based on reaction-diffusion partial differential equations describing a transmissible disease. The nonlinear model takes into account the…

Optimization and Control · Mathematics 2023-08-25 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi

Compartment models with delay terms are widely used across a range of disciplines. The motivation to include delay terms varies across different contexts. In epidemiological and pharmacokinetic models, the delays are often used to represent…

Dynamical Systems · Mathematics 2024-06-26 Christopher N. Angstmann , Anna V. McGann , Zhuang Xu

We investigate steady states of a quasilinear first order hyperbolic partial integro-differential equation. The model describes the evolution of a hierarchical structured population with distributed states at birth. Hierarchical…

Analysis of PDEs · Mathematics 2019-03-25 J. Z. Farkas , P. Hinow

Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously…

Populations and Evolution · Quantitative Biology 2017-10-12 Peter Ashcroft , Markus G. Manz , Sebastian Bonhoeffer

Proliferating cell populations at steady state growth often exhibit broad protein distributions with exponential tails. The sources of this variation and its universality are of much theoretical interest. Here we address the problem by…

Populations and Evolution · Quantitative Biology 2008-07-24 Tamar Friedlander , Naama Brenner

Periodic patterns in dynamical behaviours of biological models described by simple form differential delay equations are studied. Mathematical models are given by a class of scalar delay differential equations with a multiplicative time…

Dynamical Systems · Mathematics 2025-10-01 A. Ivanov , S. Shelyag

Traditionally, population models distinguish individuals on the basis of their current state. Given a distribution, a discrete time model then specifies (precisely in deterministic models, probabilistically in stochastic models) the…

Populations and Evolution · Quantitative Biology 2023-09-21 B. Boldin , O. Diekmann , J. A. J. Metz

In this paper, a delay differential equations (DDEs) model of leukemia is introduced and its dynamical properties are investigated in comparison with the modified fractional-order system where the Caputo's derivative is used. The model…

Populations and Evolution · Quantitative Biology 2017-01-31 Ileana Rodica Radulescu , Doina Candea , Eva Kaslik

We consider a time-fractional parabolic equation of doubly nonlinear type, featuring nonlinear terms both inside and outside the differential operator in time. The main nonlinearities are maximal monotone graphs, without restrictions on the…

Analysis of PDEs · Mathematics 2025-08-20 Goro Akagi , Giacomo Enrico Sodini , Ulisse Stefanelli

Step meandering due to a deterministic morphological instability on vicinal surfaces during growth is studied. We investigate nonlinear dynamics of a step model with asymmetric step kinetics, terrace and line diffusion, by means of a…

Statistical Mechanics · Physics 2009-10-31 F. Gillet , O. Pierre-Louis , C. Misbah

This article presents a partial differential equation (PDE) of Keller-Segel (KS) type that reproduces patterns commonly observed during the growth of brain microvasculature. We provide mathematical insights into the mechanisms underlying…

Dynamical Systems · Mathematics 2026-05-04 B Ambrosio , A Garroudji , S. Fitzsimons , H Zaag , F. M. Elahi

Most conspicuous organisms are multicellular and most multicellular organisms develop somatic cells to perform specific, non-reproductive tasks. The ubiquity of this division of labor suggests that it is highly advantageous. In this paper,…

Populations and Evolution · Quantitative Biology 2008-01-18 Martin Willensdorfer

The now classical replicator equation describes a wide variety of biological phenomena, including those in theoretical genetics, evolutionary game theory, or in the theories of the origin of life. Among other questions, the permanence of…

Populations and Evolution · Quantitative Biology 2016-03-21 Alexander S. Bratus , Vladimir P. Posvyanskii , Artem S. Novozhilov

We study a quite general family of nonlinear evolution equations of diffusive type with nonlocal effects. More precisely, we study porous medium equations with a fractional Laplacian pressure, and the problem is posed on a bounded space…

Analysis of PDEs · Mathematics 2017-08-03 Quoc-Hung Nguyen , Juan Luis Vázquez

The movement of organisms and cells can be governed by occasional long distance runs, according to an approximate L\'evy walk. For T cells migrating through chronically-infected brain tissue, runs are further interrupted by long pauses, and…

Biological Physics · Physics 2020-03-06 Gissell Estrada-Rodriguez , Heiko Gimperlein , Kevin J. Painter , Jakub Stocek

We consider a system $\displaystyle \frac{dx}{dt}=r_1(t) G_1(x) \left[ \int_{h_1(t)}^t f_1(y(s))~d_s R_1 (t,s) - x(t) \right], \frac{dy}{dt}=r_2(t) G_2(y) \left[ \int_{h_2(t)}^t f_2(x(s))~d_s R_2 (t,s) - y(t)\right]$ with increasing…

Dynamical Systems · Mathematics 2016-06-15 Leonid Berezansky , Elena Braverman

We consider a population organised hierarchically with respect to size in such a way that the growth rate of each individual depends only on the presence of larger individuals. As a concrete example one might think of a forest, in which the…

Populations and Evolution · Quantitative Biology 2024-04-23 Carles Barril , Àngel Calsina , Odo Diekmann , József Z. Farkas

We study global regularity of nonlinear systems of partial differential equations depending on the symmetric part of the gradient with Dirichlet boundary conditions. These systems arise from variational problems in plasticity with power…

Analysis of PDEs · Mathematics 2023-10-27 Linus Behn , Lars Diening