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Many biological, physical, and social interactions have a particular dependence on where they take place. In living cells, protein movement between the nucleus and cytoplasm affects cellular response (i.e., proteins must be present in the…

Molecular Networks · Quantitative Biology 2012-10-11 Heather A. Harrington , Elisenda Feliu , Carsten Wiuf , Michael M. P. Stumpf

A viable strategy for enhancing photovoltaic performance in a double quantum dot (DQD) photocell is to comprehend the underlying quantum physical regime of charge transfer. This work explores the photovoltaic performance dependent spatially…

Applied Physics · Physics 2024-02-06 Sheng-Nan Zhu , Shun-Cai Zhao , Lu-Xin Xu , Lin-Jie Chen

We consider a type of optimal switching problems with non-uniform execution delays and ramping. Such problems frequently occur in the operation of economical and engineering systems. We first provide a solution to the problem by applying a…

Optimization and Control · Mathematics 2017-02-15 Magnus Perninge

We study a mutation-selection model with a fluctuating environment. More precisely, individuals in a large population are assumed to have a modifier locus determining the mutation rate $u \in [0,\vartheta]$ at a second locus with types $v…

Probability · Mathematics 2019-09-16 Franz Baumdicker , Elisabeth Huss , Peter Pfaffelhuber

Stochastic models of sequential mutation acquisition are widely used to quantify cancer and bacterial evolution. Across manifold scenarios, recurrent research questions are: how many cells are there with $n$ alterations, and how long will…

Populations and Evolution · Quantitative Biology 2023-07-07 Michael D. Nicholson , David Cheek , Tibor Antal

Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay…

Molecular Networks · Quantitative Biology 2015-06-16 Chinmaya Gupta , José Manuel López , William Ott , Krešimir Josíc , Matthew R. Bennett

Mutation rate is a key determinant of the pace as well as outcome of evolution, and variability in this rate has been shown in different scenarios to play a key role in evolutionary adaptation and resistance evolution under stress caused by…

Populations and Evolution · Quantitative Biology 2019-03-01 Dalit Engelhardt , Eugene I. Shakhnovich

Phosphorelays are a class of signaling mechanisms used by cells to respond to changes in their environment. Phosphorelays (of which two-component systems constitute a special case) are particularly abundant in prokaryotes and have been…

Molecular Networks · Quantitative Biology 2011-09-26 Michael Knudsen , Elisenda Feliu , Carsten Wiuf

Delays are inherent to most dynamical systems. Besides shifting the process in time, they can significantly affect their performance. For this reason, it is usually valuable to study the delay and account for it. Because they are dynamical…

Machine Learning · Computer Science 2023-09-21 Pierre Liotet

Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely available, the…

Genomics · Quantitative Biology 2017-08-23 Qing Zhang , Federico Bassetti , Marco Gherardi , Marco Cosentino Lagomarsino

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…

Biological Physics · Physics 2015-04-02 A. -K. Gustavsson , C. B. Adiels , B. Mehlig , M. Goksör

The recent interest in human dynamics has led researchers to investigate the stochastic processes that explain human behaviour in different contexts. Here we propose a generative model to capture the essential dynamics of survival analysis,…

Physics and Society · Physics 2015-06-18 Trevor Fenner , Mark Levene , George Loizou

Biological organisms exhibit diverse strategies for adapting to varying environments. For example, a population of organisms may express the same phenotype in all environments (`unvarying strategy'), or follow environmental cues and express…

Populations and Evolution · Quantitative Biology 2022-06-08 BingKan Xue , Pablo Sartori , Stanislas Leibler

Perfect synchronicity in $N$-player games is a useful theoretical dream, but communication delays are inevitable and may result in asynchronous interactions. Some systems such as financial markets are asynchronous by design, and yet most…

Physics and Society · Physics 2015-05-13 Giancarlo Mosetti , Damien Challet , Sorin Solomon

The effect caused by the presence of a number of distinct time scales in a simple stochastic model for the Earth's atmosphere temperature fluctuations is studied. The model is described by a dissipative dynamics consisting of a set of…

Atmospheric and Oceanic Physics · Physics 2007-05-23 Arturo Berrones

We construct and analyze structured replicator dynamics of the Snowdrift game. In our model, the offspring is put in juvenile compartments and then mature and join adult compartments with strategy-dependent rates. This is augmented by death…

Populations and Evolution · Quantitative Biology 2025-06-06 Jacek Miekisz , Javad Mohamadichamgavi

Competition between individuals drives the evolution of whole species. Although the fittest individuals survive the longest and produce the most offspring, in some circumstances the resulting species may not be optimally fit. Here, using…

Populations and Evolution · Quantitative Biology 2015-09-24 Tim Rogers , Alan J. McKane

We develop a stochastic model to study the specific response of the immune system. The model is based on the dynamical interaction between Regulatory and Effector CD4+ T cells in the presence of Antigen Presenting Cells inside a lymphatic…

Cell Behavior · Quantitative Biology 2011-04-29 Nuris Figueroa-Morales , Kalet León , Roberto Mulet

Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery that recognizes and corrects specific errors. Here we study…

Populations and Evolution · Quantitative Biology 2026-05-14 Riccardo Ravasio , Kabir Husain , Constantine G. Evans , Rob Phillips , Marco Ribezzi-Crivellari , Jack W. Szostak , Arvind Murugan

The time-delay-based reservoir computing setup has seen tremendous success in both experiment and simulation. It allows for the construction of large neuromorphic computing systems with only few components. However, until now the interplay…

Adaptation and Self-Organizing Systems · Physics 2021-08-09 Florian Stelzer , André Röhm , Kathy Lüdge , Serhiy Yanchuk
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