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In neural circuits, synaptic strengths influence neuronal activity by shaping network dynamics, and neuronal activity influences synaptic strengths through activity-dependent plasticity. Motivated by this fact, we study a recurrent-network…

Neurons and Cognition · Quantitative Biology 2024-01-12 David G. Clark , L. F. Abbott

Feedback-rich neural architectures can regenerate earlier representations and inject temporal context, making them a natural setting for strictly local synaptic plasticity. Existing literature raises doubt about whether a minimal,…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Josh Li , Fow-sen Choa

In order to assess the short-term memory performance of non-linear random neural networks, we introduce a measure to quantify the dependence of a neural representation upon the past context. We study this measure both numerically and…

Disordered Systems and Neural Networks · Physics 2016-03-08 Gilles Wainrib

While most models of randomly connected networks assume nodes with simple dynamics, nodes in realistic highly connected networks, such as neurons in the brain, exhibit intrinsic dynamics over multiple timescales. We analyze how the…

Disordered Systems and Neural Networks · Physics 2019-09-11 Samuel P. Muscinelli , Wulfram Gerstner , Tilo Schwalger

When brain signals are recorded in an electroencephalogram or some similar large-scale record of brain activity, oscillatory patterns are typically observed that are thought to reflect the aggregate electrical activity of the underlying…

Neurons and Cognition · Quantitative Biology 2013-06-04 Andre Nathan , Valmir C. Barbosa

Controlling the flow and routing of data is a fundamental problem in many distributed networks, including transportation systems, integrated circuits, and the Internet. In the brain, synaptic plasticity rules have been discovered that…

Neural and Evolutionary Computing · Computer Science 2017-04-18 Jonathan Y. Suen , Saket Navlakha

Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuits exhibit markedly different…

Neurons and Cognition · Quantitative Biology 2025-10-28 David G. Clark , Owen Marschall , Alexander van Meegen , Ashok Litwin-Kumar

Structural and functional heterogeneity are hallmarks of cortical circuits, from broad degree distributions in the mouse connectome to diverse intrinsic neuronal timescales. Yet a mechanistic link between connectivity heterogeneity and…

Neurons and Cognition · Quantitative Biology 2026-03-05 Marco Zenari , Luca Taffarello , Luca Mazzucato , Amos Maritan , Samir Suweis

Dimensionality reduction, a form of compression, can simplify representations of information to increase efficiency and reveal general patterns. Yet, this simplification also forfeits information, thereby reducing representational capacity.…

We present exact results, as well as some illustrative Monte Carlo simulations, concerning a stochastic network with weighted connections in which the fraction of nodes that are dynamically synchronized is a parameter. This allows one to…

Disordered Systems and Neural Networks · Physics 2007-05-23 J. Marro , J. J. Torres , J. M. Cortes , B. Wemmenhove

Recent empirical evidence has demonstrated that the training dynamics of large-scale deep neural networks occur within low-dimensional subspaces. While this has inspired new research into low-rank training, compression, and adaptation,…

Machine Learning · Computer Science 2026-02-09 Alec S. Xu , Can Yaras , Matthew Asato , Qing Qu , Laura Balzano

Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its…

Neurons and Cognition · Quantitative Biology 2025-01-09 David G. Clark , Manuel Beiran

Many physical systems--from mechanical lattices and electrical circuits to biological tissues and architected metamaterials--can be understood as networks transmitting physical quantities. We present a unified mathematical framework for…

Soft Condensed Matter · Physics 2025-08-07 José M. Ortiz-Tavárez , William Stephenson , Xiaoming Mao

A mechanism for self-organization of the degree of connectivity in model neural networks is studied. Network connectivity is regulated locally on the basis of an order parameter of the global dynamics which is estimated from an observable…

Statistical Mechanics · Physics 2009-11-07 Stefan Bornholdt , Torsten Roehl

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

Task-based modeling with recurrent neural networks (RNNs) has emerged as a popular way to infer the computational function of different brain regions. These models are quantitatively assessed by comparing the low-dimensional neural…

Neurons and Cognition · Quantitative Biology 2019-12-06 Niru Maheswaranathan , Alex H. Williams , Matthew D. Golub , Surya Ganguli , David Sussillo

The observation of critical-like behavior in cortical networks represents a major step forward in elucidating how the brain manages information. Understanding the origin and functionality of critical-like dynamics, as well as their…

Neurons and Cognition · Quantitative Biology 2015-06-22 Paula Villa Martín , Paolo Moretti , Miguel A. Muñoz

Feedback loops in a dynamic network play an important role in determining the dynamics of that network. Through a computational study, in this paper we show that networks with fewer independent negative feedback loops tend to exhibit more…

Quantitative Methods · Quantitative Biology 2009-11-13 Eduardo Sontag , Alan Veliz-Cuba , Reinhard Laubenbacher , Abdul Salam Jarrah

Mathematical modeling has broad applications in neuroscience whether modeling the dynamics of a single synapse or an entire network of neurons. In Part I, we model vesicle replenishment and release at the photoreceptor synapse to better…

Neurons and Cognition · Quantitative Biology 2017-02-23 Caitlyn M. Parmelee

Neural circuits exhibit structured connectivity, including an overrepresentation of reciprocal connections between neuron pairs. Despite important advances, a full understanding of how such partial symmetry in connectivity shapes neural…