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A class of nonlinear models combining a pharmacokinetic compartmental model and a pharmacodynamic Emax model is introduced. The locally D-optimal (LD) design for a four-parameter composed model is found to be a saturated four-point uniform…

Methodology · Statistics 2008-12-18 X. Fang , A. S. Hedayat

We consider the joint problem of online experiment design and parameter estimation for identifying nonlinear system models, while adhering to system constraints. We utilize a receding horizon approach and propose a new adaptive input design…

Systems and Control · Electrical Eng. & Systems 2025-12-02 Jingwei Hu , Dave Zachariah , Torbjörn Wigren , Petre Stoica

We study nonlinear regression of real valued data in an individual sequence manner, where we provide results that are guaranteed to hold without any statistical assumptions. We address the convergence and undertraining issues of…

Machine Learning · Computer Science 2014-10-08 N. Denizcan Vanli , Muhammed O. Sayin , Suleyman S. Kozat

In this paper an approach to modelling nonstationary binary sequences, i.e., predicting the probability of upcoming symbols, is presented. After studying the prediction model we evaluate its performance in two non-artificial test cases.…

Information Theory · Computer Science 2013-02-13 Christopher Mattern

Nonlinear systems play a significant role in numerous scientific and engineering disciplines, and comprehending their behavior is crucial for the development of effective control and prediction strategies. This paper introduces a novel…

Systems and Control · Electrical Eng. & Systems 2023-08-15 Kaushal Kumar

In this paper we present a novel numerical method for computing local minimizers of twice smooth differentiable non-linear programming (NLP) problems. So far all algorithms for NLP are based on either of the following three principles:…

Numerical Analysis · Mathematics 2018-03-06 Martin Neuenhofen

For parameterized mixed-binary optimization problems, we construct local decision rules that prescribe near-optimal courses of action across a set of parameter values. The decision rules stem from solving risk-adaptive training problems…

Optimization and Control · Mathematics 2024-04-24 Johannes O. Royset , Miguel A. Lejeune

In machine learning and data mining, linear models have been widely used to model the response as parametric linear functions of the predictors. To relax such stringent assumptions made by parametric linear models, additive models consider…

Machine Learning · Statistics 2017-10-18 Sheng Chen , Arindam Banerjee

A common problem in Phase II clinical trials is the comparison of dose response curves corresponding to different treatment groups. If the effect of the dose level is described by parametric regression models and the treatments differ in…

Statistics Theory · Mathematics 2016-03-16 Chrystel Feller , Kirsten Schorning , Holger Dette , Georgina Bermann , Björn Bornkamp

This paper presents a new and efficient method for the construction of optimal designs for regression models with dependent error processes. In contrast to most of the work in this field, which starts with a model for a finite number of…

Methodology · Statistics 2015-11-06 Holger Dette , Maria Konstantinou , Anatoly Zhigljavsky

In linear regression with fixed design, we propose two procedures that aggregate a data-driven collection of supports. The collection is a subset of the $2^p$ possible supports and both its cardinality and its elements can depend on the…

Statistics Theory · Mathematics 2016-06-01 Pierre C. Bellec

In topology optimization of compliant mechanisms, the specific placement of boundary conditions strongly affects the resulting material distribution and performance of the design. At the same time, the most effective locations of the loads…

Computational Engineering, Finance, and Science · Computer Science 2025-02-05 Lee R. Alacoque , Anurag Bhattacharyya , Kai A. James

We introduce two new tools that can be useful in nonlinear observer and output feedback design. The first one is a simple extension of the notion of homogeneous approximation to make it valid both at the origin and at infinity (homogeneity…

Optimization and Control · Mathematics 2009-03-03 Vincent Andrieu , Laurent Praly , Alessandro Astolfi

The goal of subsampling is to select an informative subset of all observations, when using the full data for statistical analysis is not viable. We construct locally $ D $-optimal subsampling designs under a Poisson regression model with a…

Statistics Theory · Mathematics 2024-03-28 Torsten Reuter , Rainer Schwabe

We consider regression problems with binary weights. Such optimization problems are ubiquitous in quantized learning models and digital communication systems. A natural approach is to optimize the corresponding Lagrangian using variants of…

Machine Learning · Computer Science 2020-12-01 Nisan Chiprut , Amir Globerson , Ami Wiesel

In this work, we consider a multivariate regression model with one-sided errors. We assume for the regression function to lie in a general H\"{o}lder class and estimate it via a nonparametric local polynomial approach that consists of…

Statistics Theory · Mathematics 2021-02-11 Leonie Selk , Charles Tillier , Orlando Marigliano

High dimensional predictive regressions are useful in wide range of applications. However, the theory is mainly developed assuming that the model is stationary with time invariant parameters. This is at odds with the prevalent evidence for…

Econometrics · Economics 2019-10-09 Kashif Yousuf , Serena Ng

Based on the tensor-based large margin distribution and the nonparallel support tensor machine, we establish a novel classifier for binary classification problem in this paper, termed the Large Margin Distribution based NonParallel Support…

Optimization and Control · Mathematics 2025-07-18 Zhuolin Du , Yisheng Song

We introduce a generic class of dynamic nonlinear heterogeneous parameter models that incorporate individual and time fixed effects in both the intercept and slope. These models are subject to the incidental parameter problem, in that the…

Econometrics · Economics 2026-01-27 Xuan Leng , Jiaming Mao , Yutao Sun

Cumulative link models have been widely used for ordered categorical responses. Uniform allocation of experimental units is commonly used in practice, but often suffers from a lack of efficiency. We consider D-optimal designs with ordered…

Statistics Theory · Mathematics 2017-11-09 Jie Yang , Liping Tong , Abhyuday Mandal