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Many recently introduced enhanced sampling techniques are based on biasing coarse descriptors (collective variables) of a molecular system on the fly. Sometimes the calculation of such collective variables is expensive and becomes a…

Computational Physics · Physics 2015-09-01 Marco Jacopo Ferrarotti , Sandro Bottaro , Andrea Pérez-Villa , Giovanni Bussi

We use transition path sampling to study evaporation in the SPC/E model of liquid water. Based on thousands of evaporation trajectories, we characterize the members of the transition state ensemble (TSE), which exhibit a liquid-vapor…

Soft Condensed Matter · Physics 2014-09-05 Patrick Varilly , David Chandler

A comprehensive description of molecular electron transfer reactions is essential for our understanding of fundamental phenomena in bio-energetics and molecular electronics. Experimental studies of molecular systems in condensed-phase…

Quantum Physics · Physics 2021-02-04 Frank Schlawin , Manuel Gessner , Andreas Buchleitner , Tobias Schaetz , Spiros S Skourtis

We present alphaPDE, a new multivariate analysis technique for parameter estimation. The method is based on a direct construction of joint probability densities of known variables and the parameters to be estimated. We show how posterior…

Data Analysis, Statistics and Probability · Physics 2009-11-07 B. Knuteson , H. Miettinen , L. Holmstrom

The normalizing constant plays an important role in Bayesian computation, and there is a large literature on methods for computing or approximating normalizing constants that cannot be evaluated in closed form. When the normalizing constant…

Computation · Statistics 2020-09-02 Yuling Yao , Collin Cademartori , Aki Vehtari , Andrew Gelman

Subjective assessment tests are often employed to evaluate image processing systems, notably image and video compression, super-resolution among others and have been used as an indisputable way to provide evidence of the performance of an…

Multimedia · Computer Science 2023-11-13 Shima Mohammadi , Joao Ascenso

We present generalized-ensemble algorithms for isobaric-isothermal molecular simulations. In addition to the multibaric-multithermal algorithm and replica-exchange method for the isobaric-isothermal ensemble, which have already been…

Statistical Mechanics · Physics 2010-04-14 Yoshiharu Mori , Yuko Okamoto

Methods that combine collective variable (CV) based enhanced sampling and global tempering approaches are used in speeding-up the conformational sampling and free energy calculation of large and soft systems with a plethora of energy…

Computational Physics · Physics 2021-09-01 Anji Babu Kapakayala , Nisanth N. Nair

In view of the node importance in weighted networks, weighted expected method (WEM), was proposed in this paper, which take an advantages of uncertain graph algorithm. First, a weight processing method is proposed based on the relationship…

Social and Information Networks · Computer Science 2021-11-23 Linjie Chen , Na Zhao , Jie Li , Zhen Long , Ming Jing , Jian Wang

An energy-biased method to evaluate ensemble averages requiring test-particle insertion is presented. The method is based on biasing the sampling within the subdomains of the test-particle configurational space with energies smaller than a…

Chemical Physics · Physics 2009-11-11 R. Delgado-Buscalioni , G. De Fabritiis , P. V. Coveney

Understanding transition pathways between two meta-stable states of a molecular system is crucial to advance drug discovery and material design. However, unbiased molecular dynamics (MD) simulations are computationally infeasible because of…

Machine Learning · Computer Science 2025-01-28 Kiyoung Seong , Seonghyun Park , Seonghwan Kim , Woo Youn Kim , Sungsoo Ahn

Bayesian optimisation is a sample efficient method for finding a global optimum of expensive black-box objective functions. Historic datasets from related problems can be exploited to help improve performance of Bayesian optimisation by…

Machine Learning · Computer Science 2026-01-23 Natasha Trinkle , Huong Ha , Jeffrey Chan

Regression analysis is commonly conducted in survey sampling. However, existing methods fail when the relationships vary across different areas or domains. In this paper, we propose a unified framework to study the group-wise covariate…

Methodology · Statistics 2024-09-25 Mingjun Gang , Xin Wang , Zhonglei Wang , Wei Zhong

The replica exchange molecular dynamics (REMD) approach is applied to four oligomeric peptide systems. At physiologically relevant temperature values REMD samples conformation space and aggregation transitions more efficiently than constant…

Biomolecules · Quantitative Biology 2009-11-10 M. Cecchini , F. Rao , M. Seeber , A. Caflisch

Quasi two-dimensional Coulomb systems have drawn widespread interest. The reduced symmetry of these systems leads to complex collective behaviors, yet simultaneously poses significant challenges for particle-based simulations. In this…

Numerical Analysis · Mathematics 2025-07-15 Zecheng Gan , Xuanzhao Gao , Jiuyang Liang , Zhenli Xu

Channel estimation is essential to massive multiple-input multiple-output (MIMO) systems. While recent generative model-based approaches using lightweight diffusion models (DMs) have achieved superior performance, they typically rely on a…

Signal Processing · Electrical Eng. & Systems 2026-05-19 Zhuorui Jiang , Jun Fang , Boyu Ning , Hongbin Li , Ying-Chang Liang

Transition states and minimum energy paths are essential to understand and predict chemical reactivity. Double-ended methods represent a standard approach for their determination. We introduce a new double-ended method that optimizes…

Chemical Physics · Physics 2020-02-18 Alain C. Vaucher , Markus Reiher

Robust beamforming is a pivotal technique in massive multiple-input multiple-output (MIMO) systems as it mitigates interference among user equipment (UE). One current risk-neutral approach to robust beamforming is the stochastic weighted…

Applications · Statistics 2024-04-10 Ying Li , Zhidi Lin , Kai Li , Michael Minyi Zhang

We study the condensation phenomenon in a zero range process on weighted scale-free networks in order to show how the weighted transport influences the particle condensation. Instead of the approach of grand canonical ensemble which is…

Statistical Mechanics · Physics 2008-02-26 Ming Tang , Zonghua Liu , Jie Zhou

We investigate the theoretical foundations of the simulated tempering method and use our findings to design efficient algorithms. Employing a large deviation argument first used for replica exchange molecular dynamics [Plattner et al., J.…

Chemical Physics · Physics 2019-02-08 Anton Martinsson , Jianfeng Lu , Benedict Leimkuhler , Eric Vanden-Eijnden