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In this paper we present a simple microscopic stochastic model describing short term plasticity within a large homogeneous network of interacting neurons. Each neuron is represented by its membrane potential and by the residual calcium…

Probability · Mathematics 2020-01-29 Antonio Galves , Eva Löcherbach , Christophe Pouzat , Errico Presutti

Computational models have become an essential part of exploratory protocols in cell biology, as a complement to in vivo or in vitro experiments. These virtual models have the twofold advantage of enabling access to new types of data and…

Medical Physics · Physics 2021-12-20 Maxime Vassaux , Laurent Pieuchot , Karine Anselme , Maxence Bigerelle , Jean-Louis Milan

We present an effective model for timing-dependent synaptic plasticity (STDP) in terms of two interacting traces, corresponding to the fraction of activated NMDA receptors and the Ca2+ concentration in the dendritic spine of the…

Neurons and Cognition · Quantitative Biology 2015-02-26 Rodrigo Echeveste , Claudius Gros

This paper investigates a spherical transmitter (TX) with a membrane covered by heterogeneous receptors of varying sizes and arbitrary locations for molecular communication (MC), where molecules are encapsulated within vesicles and released…

Emerging Technologies · Computer Science 2023-07-27 Xinyu Huang , Yu Huang , Miaowen Wen , Nan Yang , Robert Schober

In synaptic molecular communication (MC), the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process. This randomness of synaptic MC contributes to the randomness of the…

Subcellular Processes · Quantitative Biology 2023-01-18 Sebastian Lotter , Maximilian Schäfer , Robert Schober

We investigate spike-timing dependent plasticity (STPD) in the case of a synapse connecting two neural cells. We develop a theoretical analysis of several STDP rules using Markovian theory. In this context there are two different…

Neurons and Cognition · Quantitative Biology 2021-11-16 Philippe Robert , Gaëtan Vignoud

A spatially distributed system contains a large amount of agents with limited sensing, data processing, and communication capabilities. Recent technological advances have opened up possibilities to deploy spatially distributed systems for…

Information Theory · Computer Science 2015-11-30 Cheng Cheng , Yingchun Jiang , Qiyu Sun

We characterize the pre-softmax attention matrix $\mathbf{QK^\top}$ in transformers as an associative memory matrix encoding pairwise associations between input features. By decomposing this matrix into its symmetric and skew-symmetric…

Machine Learning · Computer Science 2026-05-28 Hyunmin Cho , Woo Kyoung Han , Kyong Hwan Jin

We propose a new model based on the Ising model with the aim to study synaptic plasticity phenomena in neural networks. It is today well established in biology that the synapses or connections between certain types of neurons are…

Disordered Systems and Neural Networks · Physics 2016-07-22 Eugene Pechersky , Guillem Via , Anatoly Yambartsev

Synaptic plasticity, the dynamic tuning of signal transmission strength between neurons, serves as a fundamental basis for memory and learning in biological organisms. This adaptive nature of synapses is considered one of the key features…

Mesoscale and Nanoscale Physics · Physics 2024-11-11 Yechan Noh , Alex Smolyanitsky

Multicellular coordination relies on broadcast-addressable receptors, yet engineered magnetic systems face an addressability bottleneck because global fields intrinsically conflate power and control. Here, we introduce MagCeptors to resolve…

Systems and Control · Electrical Eng. & Systems 2026-05-20 Sishen Yuan , Baijia Liang , Tangyou Liu , Yiqing Huang , Haoxuan Wu , Shuo Xu , Hongliang Ren

A method is provided for approximating random slow manifolds of a class of slow-fast stochastic dynamical systems. Thus approximate, low dimensional, reduced slow systems are obtained analytically in the case of sufficiently large time…

Dynamical Systems · Mathematics 2013-03-12 Jian Ren , Jinqiao Duan , Christopher K. R. T. Jones

One of the aims of systems biology is to build multiple layered and multiple scale models of living systems which can efficiently describe phenomena occurring at various level of resolution. Such models should consist of layers of various…

Dynamical Systems · Mathematics 2015-03-03 Jacek Banasiak , Aleksandra Falkiewicz , Proscovia Namayanja

The presence of one or more species at some spatial locations but not others is a central matter in ecology. This phenomenon is related to ecological pattern formation. Nonlocal interactions can be considered as one of the mechanisms…

Populations and Evolution · Quantitative Biology 2017-12-29 Ozgur Aydogmus

The aggregation or clustering of proteins and other macromolecules plays an important role in the formation of large-scale molecular assemblies within cell membranes. Examples include lipid rafts and postsynaptic domains (PSDs). PSDs are…

Soft Condensed Matter · Physics 2023-12-12 Paul C Bressloff

We study the dynamics of a seeding experiment where a fibrous scaffold material is colonized by two types of cell populations. The specific application that we have in mind is related to the idea of meniscus tissue regeneration. In order to…

Rhythmic activity has been associated with a wide range of cognitive processes. Previous studies have shown that spike-timing-dependent plasticity can facilitate the transfer of rhythmic activity downstream the information processing…

Neurons and Cognition · Quantitative Biology 2020-09-09 Nimrod Sherf , Maoz Shamir

Motivated by the experimental study of Tayebi et al. [Nature Mater. 11, 1074 (2012)] on phase separation of stacked multi-component lipid bilayers, we propose a model composed of stacked two-dimensional Ising spins. We study both its static…

Soft Condensed Matter · Physics 2015-12-14 T. Hoshino , S. Komura , D. Andelman

Biopolymers serve as one-dimensional tracks on which motor proteins move to perform their biological roles. Motor protein phenomena have inspired theoretical models of one-dimensional transport, crowding, and jamming. Experiments studying…

Biological Physics · Physics 2016-05-25 Hui-Shun Kuan , M. D. Betterton

Proteins with multiple binding sites play important roles in cell signaling systems by nucleating protein complexes in which, for example, enzymes and substrates are co-localized. Proteins that specialize in this function are called by a…

Molecular Networks · Quantitative Biology 2011-09-12 Jin Yang , William S. Hlavacek