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Data mining techniques have been used by researchers for analyzing protein sequences. In protein analysis, especially in protein sequence classification, selection of feature is most important. Popular protein sequence classification…

Databases · Computer Science 2012-11-22 Suprativ Saha , Rituparna Chaki

Sequence alignment is common nowadays as it is used in many fields to determine how closely two sequences are related and at times to see how little they differ. In computational biology / Bioinformatics, there are many algorithms developed…

Information Theory · Computer Science 2023-05-02 Bharath Reddy , Richard Fields

As the structural databases continue to expand, efficient methods are required to search similar structures of the query structure from the database. There are many previous works about comparing protein 3D structures and scanning the…

Databases · Computer Science 2011-02-16 Gook-Pil Roh , Seung-won Hwang , Byoung-Kee Yi

Protein sequence classification involves feature selection for accurate classification. Popular protein sequence classification techniques involve extraction of specific features from the sequences. Researchers apply some well-known…

Computational Engineering, Finance, and Science · Computer Science 2012-11-21 Suprativ Saha , Rituparna Chaki

Classification in the dissimilarity space has become a very active research area since it provides a possibility to learn from data given in the form of pairwise non-metric dissimilarities, which otherwise would be difficult to cope with.…

In this work we set out to find a method to classify protein structures using a Deep Learning methodology. Our Artificial Intelligence has been trained to recognize complex biomolecule structures extrapolated from the Protein Data Bank…

Machine Learning · Computer Science 2021-11-04 Damiano Perri , Marco Simonetti , Andrea Lombardi , Noelia Faginas-Lago , Osvaldo Gervasi

Consider two networks on overlapping, non-identical vertex sets. Given vertices of interest in the first network, we seek to identify the corresponding vertices, if any exist, in the second network. While in moderately sized networks graph…

Machine Learning · Statistics 2019-11-07 Heather G. Patsolic , Youngser Park , Vince Lyzinski , Carey E. Priebe

The study of the classifier's design and it's usage is one of the most important machine learning areas. With the development of automatic machine learning methods, various approaches are used to build a robust classifier model. Due to some…

Machine Learning · Computer Science 2021-01-22 Ivan Gridin

The exponential growth of scientific publications in recent years has posed a significant challenge in effective and efficient categorization. This paper introduces a novel approach that combines instance-based learning and ensemble…

Digital Libraries · Computer Science 2024-09-24 Fang Zhang , Shengli Wu

The Closest String Problem is an NP-hard problem that aims to find a string that has the minimum distance from all sequences that belong to the given set of strings. Its applications can be found in coding theory, computational biology, and…

Artificial Intelligence · Computer Science 2024-07-19 Alireza Abdi , Marko Djukanovic , Hesam Tahmasebi Boldaji , Hadis Salehi , Aleksandar Kartelj

A system of nested dichotomies is a method of decomposing a multi-class problem into a collection of binary problems. Such a system recursively splits the set of classes into two subsets, and trains a binary classifier to distinguish…

Machine Learning · Statistics 2016-07-06 Tim Leathart , Bernhard Pfahringer , Eibe Frank

This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

Genomics · Quantitative Biology 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer

Foundation models have impressive performance and generalization capabilities across a wide range of applications. The increasing size of the models introduces great challenges for the training. Tensor parallelism is a critical technique…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-23 Shenggan Cheng , Ziming Liu , Jiangsu Du , Yang You

Spaced seeds are important tools for similarity search in bioinformatics, and using several seeds together often significantly improves their performance. With existing approaches, however, for each seed we keep a separate linear-size data…

Data Structures and Algorithms · Computer Science 2014-03-11 Travis Gagie , Giovanni Manzini , Daniel Valenzuela

Patent data is an important source of knowledge for innovation research, while the technological similarity between pairs of patents is a key enabling indicator for patent analysis. Recently researchers have been using patent vector space…

Computation and Language · Computer Science 2022-08-08 Hamid Bekamiri , Daniel S. Hain , Roman Jurowetzki

We implement an algorithm for solving the minimum weight perfect matching problem. Our code significantly outperforms the current state-of-the-art Blossom V algorithm on those families of instances where Blossom V takes superlinear time. In…

Data Structures and Algorithms · Computer Science 2026-04-23 Pavel Arkhipov , Vladimir Kolmogorov

Computing the similarity between two protein structures is a crucial task in molecular biology, and has been extensively investigated. Many protein structure comparison methods can be modeled as maximum clique problems in specific k-partite…

Biomolecules · Quantitative Biology 2009-10-07 Noël Malod-Dognin , Rumen Andonov , Nicola Yanev

Protein fitness optimization involves finding a protein sequence that maximizes desired quantitative properties in a combinatorially large design space of possible sequences. Recent advances in steering protein generative models (e.g.,…

Biomolecules · Quantitative Biology 2025-10-22 Jason Yang , Wenda Chu , Daniel Khalil , Raul Astudillo , Bruce J. Wittmann , Frances H. Arnold , Yisong Yue

Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

Methodology · Statistics 2012-01-30 Alberto Cozzini , Ajay Jasra , Giovanni Montana

A seed in a word is a relaxed version of a period in which the occurrences of the repeating subword may overlap. We show a linear-time algorithm computing a linear-size representation of all the seeds of a word (the number of seeds might be…

Data Structures and Algorithms · Computer Science 2019-03-15 Tomasz Kociumaka , Marcin Kubica , Jakub Radoszewski , Wojciech Rytter , Tomasz Walen