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We investigate the solvation of methane and methane decorated with charges in spherically confined water droplets. Free energy profiles for a single methane molecule in droplets, ranging in diameter D, from 1 to 4 nm, show that the droplet…

Chemical Physics · Physics 2009-09-29 S. Vaitheeswaran , D. Thirumalai

The phase behavior of hydrocarbon fluids confined in porous media has been reported to deviate significantly from that in the bulk environment due to the existence of sub-10nm pores. Though experiments and simulations have measured the…

Soft Condensed Matter · Physics 2020-03-16 Jiaoyan Li , Qi Rao , Yidong Xia , Michael P. Hoepfner , Milind Deo

Nanoconfinement reduces the favorable hydration free energies of single ions, which is correlated with ion rejection and modified chemical reactivity in water-filled nanopores. Many factors contribute to the magnitude of the observed…

Soft Condensed Matter · Physics 2026-03-16 Kevin Leung

Interfacial interactions significantly alter the fundamental properties of water confined in mesoporous structures, with crucial implications for geological, physicochemical, and biological processes. Herein, we focused on the effect of…

Water mediates electrostatic interactions via the orientation of its dipoles around ions, molecules, and interfaces. This induced water polarization consequently influences multiple phenomena. In particular, water polarization modulated by…

Understanding the stabilities of proteins in nanopores requires a quantitative description of confinement induced interactions between amino acid side chains. We use molecular dynamics simulations to study the nature of interactions between…

Chemical Physics · Physics 2015-06-23 S. Vaitheeswaran , D. Thirumalai

Nanoscale confinement of molecules in a fluid can result in enhanced viscosity, local fluidic order, or collective motion. Confinement also affects ion transport and/or the rate and equilibrium concentration in a chemical reaction, all of…

We use molecular simulations of an ionic liquid in contact with a range of nanoporous carbons to investigate correlations between ion size, pore size, pore topology and properties of the adsorbed ions. We show that diffusion coefficients…

Materials Science · Physics 2020-02-21 El Hassane Lahrar , Anouar Belhboub , Patrice Simon , Céline Merlet

Water and water-mediated interactions determine thermodynamic and kinetics of protein folding, protein aggregation and self-assembly in confined spaces. To obtain insights into the role of water in the context of folding problems, we…

Soft Condensed Matter · Physics 2015-05-28 S. Vaitheeswaran , Jie Chen , D. Thirumalai

Fundamental studies of the effect of specific ions on hydrophobic interactions are driven by the need to understand phenomena such as hydrophobically driven self-assembly or protein folding. Using beta-peptide-inspired nano-rods, we…

Chemical Physics · Physics 2016-08-08 Kai Huang , Sebastian Gast , C. Derek Ma , Nicholas L. Abbott , Izabela Szlufarska

It is well stablished that confinement of supercooled liquids in nano-pores induces various effects as a strong modification of the dynamics and a layering of the local structure. In this work we raise the issue as how these confinement…

Mesoscale and Nanoscale Physics · Physics 2021-09-07 Felix Mercier , Gaetan Delhaye , Victor Teboul

Water plays a key role in biological membrane transport. In ion channels and water-conducting pores (aquaporins), one dimensional confinement in conjunction with strong surface effects changes the physical behavior of water. In molecular…

Biological Physics · Physics 2019-07-02 Oliver Beckstein , Mark S. P. Sansom

Ion transport in highly-confined space is important to various applications, such as biosensing and seawater desalination with nanopores. All-atom molecular dynamics simulations are conducted to investigate the transport of Na$^+$ and…

Mesoscale and Nanoscale Physics · Physics 2019-07-30 Zhongwu Li , Yinghua Qiu , Yan Zhang , Min Yue , Yunfei Chen

Hydrated excess protons under hydrophobic confinement are a critical component of charge transport behavior and reactivity in nanoporous materials and biomolecular systems. Herein excess proton confinement effects are computationally…

Soft Condensed Matter · Physics 2020-06-04 Xinyou Ma , Chenghan Li , Alex B. F. Martinson , Gregory A. Voth

We consider an electrolyte solution confined by semipermeable membranes in contact with a salt-free solvent. Membranes are uncharged, but since small counter-ions leak-out into infinite salt-free reservoirs, we observe a distance-dependent…

Soft Condensed Matter · Physics 2014-08-19 Salim R. Maduar , Olga I. Vinogradova

In this work, molecular dynamics simulations are performed to estimate the equilibrium pressure of liquid confined in nanopores. The simulations show that the pressure is highly sensitive to the pore size and can significantly change from…

Soft Condensed Matter · Physics 2021-04-21 An Zou , Shalabh C. Maroo

Past research has conclusively shown that confined pockets of water exhibit properties that differ from those of unconfined ("bulk") water. The differences between confined water and bulk, as well as between different types of confined…

Materials Science · Physics 2024-01-29 Alec A. Beaton , Alexandria Guinness , John M. Franck

The hydration free energies of ions exhibit an approximately quadratic dependence on the ionic charge, as predicted by the Born model. We analyze this behavior using second-order perturbation theory. This provides effective methods to…

chem-ph · Physics 2008-02-03 Gerhard Hummer , Lawrence R. Pratt , Angel E. Garcia

Molecular Dynamics simulations of water molecules in nanometre sized cylindrical channels connecting two reservoirs show that the permeation of water is very sensitive to the channel radius and to electric polarization of the embedding…

Soft Condensed Matter · Physics 2009-11-07 Rosalind Allen , Simone Melchionna , Jean-Pierre Hansen

Monte Carlo simulations are used to study the conformational behavior of a semiflexible polymer confined to cylindrical and conical channels. The channels are sufficiently narrow that the conditions for the Odijk regime are marginally…

Soft Condensed Matter · Physics 2020-12-02 James M. Polson , Cameron G. Hastie
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