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The minimal number of rooted subtree prune and regraft (rSPR) operations needed to transform one phylogenetic tree into another one induces a metric on phylogenetic trees - the rSPR-distance. The rSPR-distance between two phylogenetic trees…

Combinatorics · Mathematics 2023-06-22 Jonathan Klawitter

Phylogenetic networks are rooted directed acyclic graphs that represent evolutionary relationships between species whose past includes reticulation events such as hybridisation and horizontal gene transfer. To search the space of…

Combinatorics · Mathematics 2019-04-09 Jonathan Klawitter , Simone Linz

A rearrangement operation makes a small graph-theoretical change to a phylogenetic network to transform it into another one. For unrooted phylogenetic trees and networks, popular rearrangement operations are tree bisection and reconnection…

Combinatorics · Mathematics 2023-06-22 Jonathan Klawitter

Most of major algorithms for phylogenetic tree reconstruction assume that sequences in the analyzed set either do not have any offspring, or that parent sequences can maximally mutate into just two descendants. The graph resulting from such…

Populations and Evolution · Quantitative Biology 2013-10-09 Piotr Plonski , Jan P. Radomski

A variety of algorithms have been proposed for reconstructing trees that show the evolutionary relationships between species by comparing differences in genetic data across present-day taxa. If the leaf-to-leaf distances in a tree can be…

Populations and Evolution · Quantitative Biology 2014-11-18 Olivier Gascuel , Mike Steel

We study the natural problem of Triplet Reconstruction (also Rooted Triplets Consistency or Triplet Clustering), originally motivated in computational biology and relational databases (Aho, Sagiv, Szymanski, and Ullman, 1981): given $n$…

Data Structures and Algorithms · Computer Science 2023-04-06 Vaggos Chatziafratis , Konstantin Makarychev

The Neighbor-Joining algorithm is a recursive procedure for reconstructing trees that is based on a transformation of pairwise distances between leaves. We present a generalization of the neighbor-joining transformation, which uses…

Quantitative Methods · Quantitative Biology 2007-05-23 Dan Levy , Ruriko Yoshida , Lior Pachter

Due to hybridization events in evolution, studying two different genes of a set of species may yield two related but different phylogenetic trees for the set of species. In this case, we want to measure the dissimilarity of the two trees.…

Data Structures and Algorithms · Computer Science 2017-07-28 Zhi-Zhong Chen , Eita Machida , Lusheng Wang

A common assumption in multiple scientific applications is that the distribution of observed data can be modeled by a latent tree graphical model. An important example is phylogenetics, where the tree models the evolutionary lineages of a…

Machine Learning · Statistics 2020-09-24 Ariel Jaffe , Noah Amsel , Yariv Aizenbud , Boaz Nadler , Joseph T. Chang , Yuval Kluger

A central task in the study of molecular sequence data from present-day species is the reconstruction of the ancestral relationships. The most established approach to tree reconstruction is the maximum likelihood (ML) method. In this…

Quantitative Methods · Quantitative Biology 2007-05-23 Asger Hobolth , Ruriko Yoshida

The popular neighbor-joining (NJ) algorithm used in phylogenetics is a greedy algorithm for finding the balanced minimum evolution (BME) tree associated to a dissimilarity map. From this point of view, NJ is ``optimal'' when the algorithm…

Quantitative Methods · Quantitative Biology 2007-10-29 Kord Eickmeyer , Peter Huggins , Lior Pachter , Ruriko Yoshida

Many popular algorithms for searching the space of leaf-labelled trees are based on tree rearrangement operations. Under any such operation, the problem is reduced to searching a graph where vertices are trees and (undirected) edges are…

Data Structures and Algorithms · Computer Science 2020-07-27 Lena Collienne , Alex Gavryushkin

Recent theoretical work has demonstrated that Neighbor Joining applied to concatenated DNA sequences is a statistically consistent method of species tree reconstruction. This brief note compares the accuracy of this approach to other…

Populations and Evolution · Quantitative Biology 2016-12-07 Joseph Rusinko , Matthew McPartlon

Agreement forests continue to play a central role in the comparison of phylogenetic trees since their introduction more than 25 years ago. More specifically, they are used to characterise several distances that are based on tree…

Combinatorics · Mathematics 2025-09-23 Steven Kelk , Simone Linz , Charles Semple

Popular methods for exploring the space of rooted phylogenetic trees use rearrangement moves such as rNNI (rooted Nearest Neighbour Interchange) and rSPR (rooted Subtree Prune and Regraft). Recently, these moves were generalized to rooted…

Combinatorics · Mathematics 2021-01-01 Remie Janssen , Mark Jones , Péter L. Erdős , Leo van Iersel , Celine Scornavacca

Among the distance based algorithms in phylogenetic tree reconstruction, the neighbor-joining algorithm has been a widely used and effective method. We propose a new algorithm which counts the number of consistent quartets for cherry…

Populations and Evolution · Quantitative Biology 2023-10-31 Jin-Hwan Cho , Dosang Joe , Young Rock Kim

Understanding the evolution of a set of genes or species is a fundamental problem in evolutionary biology. The problem we study here takes as input a set of trees describing {possibly discordant} evolutionary scenarios for a given set of…

Data Structures and Algorithms · Computer Science 2019-07-10 Cedric Chauve , Mark Jones , Manuel Lafond , Céline Scornavacca , Mathias Weller

We develop a time-optimal $O(mn^2)$-time algorithm to construct the subtree prune-regraft (SPR) graph on a collection of m phylogenetic trees with n leaves. This improves on the previous bound of $O(mn^3)$. Such graphs are used to better…

Data Structures and Algorithms · Computer Science 2017-04-28 Chris Whidden , Frederick A. Matsen

Tree rearrangements such as Nearest Neighbor Interchange (NNI) and Subtree Prune and Regraft (SPR) are commonly used to explore phylogenetic treespace. Computing distances based on them, however, is often intractable, so the efficiently…

Populations and Evolution · Quantitative Biology 2025-12-29 Lena Collienne , Frederick A Matsen

Quartet Reconstruction, the task of recovering a phylogenetic tree from smaller trees on four species called \textit{quartets}, is a well-studied problem in theoretical computer science with far-reaching connections to statistics, graph…

Data Structures and Algorithms · Computer Science 2026-04-21 Dionysis Arvanitakis , Vaggos Chatziafratis , Yiyuan Luo , Konstantin Makarychev
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