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The quantification problem consists of determining the prevalence of a given label in a target population. However, one often has access to the labels in a sample from the training population but not in the target population. A common…

Machine Learning · Statistics 2019-04-08 Afonso Fernandes Vaz , Rafael Izbicki , Rafael Bassi Stern

The hazard ratio, typically estimated using Cox's famous proportional hazards model, is the most common effect measure used to describe the association or effect of a covariate on a time-to-event outcome. In recent years the hazard ratio…

Methodology · Statistics 2026-01-15 Jonathan W. Bartlett , Dominic Magirr , Tim P. Morris

External controls from historical trials or observational data can augment randomized controlled trials when large-scale randomization is impractical or unethical, such as in drug evaluation for rare diseases. However, non-randomized…

Methodology · Statistics 2025-05-08 Ke Zhu , Shu Yang , Xiaofei Wang

Stratifying factors, like age and gender, can modify the effect of treatments and exposures on risk of a studied outcome. Several effect measures, including the relative risk, hazard ratio, odds ratio, and risk difference, can be used to…

Methodology · Statistics 2021-11-05 Jake Shannin , Babette A. Brumback

Respondent-driven sampling (RDS) is an approach to sampling design and analysis which utilizes the networks of social relationships that connect members of the target population, using chain-referral methods to facilitate sampling. RDS…

Methodology · Statistics 2015-08-19 Yakir Berchenko , Jonathan Rosenblatt , Simon D. W. Frost

Sequential estimators are proposed for the relative risk, odds ratio, log relative risk or log odds ratio of a dichotomous attribute in two populations. The estimators take the same number of observations from each population, and guarantee…

Methodology · Statistics 2026-04-07 Luis Mendo

Adaptive sampling algorithms are modern and efficient methods that dynamically adjust the sample size throughout the optimization process. However, they may encounter difficulties in risk-averse settings, particularly due to the challenge…

Optimization and Control · Mathematics 2025-02-17 Sandra Pieraccini , Tommaso Vanzan

We derive adjusted signed likelihood ratio statistics for a general class of extreme value regression models. The adjustments reduce the error in the standard normal approximation to the distribution of the signed likelihood ratio…

Statistics Theory · Mathematics 2014-05-26 Silvia L. P. Ferrari , Eliane C. Pinheiro

Causal inference with observational studies often relies on the assumptions of unconfoundedness and overlap of covariate distributions in different treatment groups. The overlap assumption is violated when some units have propensity scores…

Methodology · Statistics 2022-07-19 Shu Yang , Peng Ding

Binary endpoints are common in clinical trials and conditional odds ratios have traditionally been used to assess treatment effects. However, the interpretation of odds ratios is difficult, they are non-collapsible and rely on strong…

Methodology · Statistics 2026-05-20 Martin Schnuerch , Alex Ocampo , Klaus Kähler Holst , Christian Stock

We address the problem that classical risk measures may not detect the tail risk adequately. This can occur for instance due to averaging when calculating the Expected Shortfall. The current literature proposes the so-called adjusted…

Mathematical Finance · Quantitative Finance 2025-04-24 Jascha Alexander , Christian Laudagé , Jörn Sass

Some risks have extremely high stakes. For example, a worldwide pandemic or asteroid impact could potentially kill more than a billion people. Comfortingly, scientific calculations often put very low probabilities on the occurrence of such…

Physics and Society · Physics 2008-10-31 Toby Ord , Rafaela Hillerbrand , Anders Sandberg

Suppose (standardized) measurements or statistics are monitored to raise an alarm when a threshold is exceeded. Often, the underlying population is heterogenous with respect to important discrete variables and thus samples may consist of…

Statistics Theory · Mathematics 2025-10-10 Ansgar Steland

This article reviews bias-correction models for measurement error of exposure variables in the field of nutritional epidemiology. Measurement error usually attenuates estimated slope towards zero. Due to the influence of measurement error,…

Methodology · Statistics 2020-07-14 Huimin Peng

Control rate regression is a diffuse approach to account for heterogeneity among studies in meta-analysis by including information about the outcome risk of patients in the control condition. Correcting for the presence of measurement error…

Methodology · Statistics 2018-03-29 Annamaria Guolo

This article introduces a new condition based on odds ratios for sensitivity analysis. The analysis involves the average effect of a treatment or exposure on a response or outcome with estimates adjusted for and conditional on a single,…

Methodology · Statistics 2023-10-11 Brian Knaeble , Julian Chan

Cross-validation under sample selection bias can, in principle, be done by importance-weighting the empirical risk. However, the importance-weighted risk estimator produces sub-optimal hyperparameter estimates in problem settings where…

Machine Learning · Computer Science 2019-08-28 Wouter M. Kouw , Jesse H. Krijthe , Marco Loog

Classically, risk is characterized by a point value probability indicating the likelihood of occurrence of an adverse effect. However, there are domains where the attainability of objective numerical risk characterizations is increasingly…

Artificial Intelligence · Computer Science 2013-02-21 Paul J. Krause , John Fox , Philip Judson

Network sampling is used around the world for surveys of vulnerable, hard-to-reach populations including people at risk for HIV, opioid misuse, and emerging epidemics. The sampling methods include tracing social links to add new people to…

Methodology · Statistics 2020-02-05 Steve Thompson

We consider basic conceptual questions concerning the relationship between statistical estimation and causal inference. Firstly, we show how to translate causal inference problems into an abstract statistical formalism without requiring any…

Statistics Theory · Mathematics 2020-07-22 Oliver J. Maclaren , Ruanui Nicholson