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Clustering is a popular unsupervised learning tool often used to discover groups within a larger population such as customer segments, or patient subtypes. However, despite its use as a tool for subgroup discovery and description - few…

Machine Learning · Computer Science 2021-12-13 Connor Lawless , Jayant Kalagnanam , Lam M. Nguyen , Dzung Phan , Chandra Reddy

To scale non-parametric extensions of probabilistic topic models such as Latent Dirichlet allocation to larger data sets, practitioners rely increasingly on parallel and distributed systems. In this work, we study data-parallel training for…

Machine Learning · Statistics 2020-10-07 Alexander Terenin , Måns Magnusson , Leif Jonsson

Joint alignment of a collection of functions is the process of independently transforming the functions so that they appear more similar to each other. Typically, such unsupervised alignment algorithms fail when presented with complex data…

Machine Learning · Computer Science 2012-10-19 Marwan A. Mattar , Allen R. Hanson , Erik G. Learned-Miller

Probabilistic clustering models (or equivalently, mixture models) are basic building blocks in countless statistical models and involve latent random variables over discrete spaces. For these models, posterior inference methods can be…

Machine Learning · Statistics 2020-06-24 Ari Pakman , Yueqi Wang , Catalin Mitelut , JinHyung Lee , Liam Paninski

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

Genomics · Quantitative Biology 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

The parsimonious Gaussian mixture models, which exploit an eigenvalue decomposition of the group covariance matrices of the Gaussian mixture, have shown their success in particular in cluster analysis. Their estimation is in general…

Machine Learning · Statistics 2018-10-18 Faicel Chamroukhi , Marius Bartcus , Hervé Glotin

The goal of data clustering is to partition data points into groups to minimize a given objective function. While most existing clustering algorithms treat each data point as vector, in many applications each datum is not a vector but a…

Machine Learning · Statistics 2017-03-16 Dinh Phung , Ba-Ngu Bo

This paper describes the hierarchical infinite relational model (HIRM), a new probabilistic generative model for noisy, sparse, and heterogeneous relational data. Given a set of relations defined over a collection of domains, the model…

Machine Learning · Computer Science 2022-02-25 Feras A. Saad , Vikash K. Mansinghka

We present the \textit{hierarchical Dirichlet scaling process} (HDSP), a Bayesian nonparametric mixed membership model. The HDSP generalizes the hierarchical Dirichlet process (HDP) to model the correlation structure between metadata in the…

Machine Learning · Computer Science 2017-07-10 Dongwoo Kim , Alice Oh

The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called "rearrangement" forming progenitor B cells, then a Darwinian…

Populations and Evolution · Quantitative Biology 2017-02-08 Duncan K. Ralph , Frederick A. Matsen

The pervasive adoption of Deep Learning (DL) and Graph Processing (GP) makes it a de facto requirement to build large-scale clusters of heterogeneous accelerators including GPUs and FPGAs. The OpenCL programming framework can be used on the…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-19 Yao Chen , Xin Long , Jiong He , Yuhang Chen , Hongshi Tan , Zhenxiang Zhang , Marianne Winslett , Deming Chen

Phylogenetic inference can potentially result in a more accurate tree using data from multiple loci. However, if the loci are incongruent--due to events such as incomplete lineage sorting or horizontal gene transfer--it can be misleading to…

Populations and Evolution · Quantitative Biology 2016-03-10 Kevin Gori , Tomasz Suchan , Nadir Alvarez , Nick Goldman , Christophe Dessimoz

Any approach aimed at pasteurizing and quantifying a particular phenomenon must include the use of robust statistical methodologies for data analysis. With this in mind, the purpose of this study is to present statistical approaches that…

Computation and Language · Computer Science 2023-06-29 Anagh Chattopadhyay , Soumya Sankar Ghosh , Samir Karmakar

Rating procedure is crucial in many applied fields (e.g., educational, clinical, emergency). It implies that a rater (e.g., teacher, doctor) rates a subject (e.g., student, doctor) on a rating scale. Given raters variability, several…

Methodology · Statistics 2026-01-14 Giuseppe Mignemi , Ioanna Manolopoulou

The Dirichlet Process Gaussian Mixture Model (DPGMM) is often used to cluster data when the number of clusters is unknown. One main DPGMM inference paradigm relies on sampling. Here we consider a known state-of-art sampler (proposed by…

Machine Learning · Computer Science 2022-03-28 Vlad Winter , Or Dinari , Oren Freifeld

Background. Conventional phylogenetic clustering approaches rely on arbitrary cutpoints applied a posteriori to phylogenetic estimates. Although in practice, Bayesian and bootstrap-based clustering tend to lead to similar estimates, they…

Methodology · Statistics 2017-08-10 Luc Villandré , Aurélie Labbe , Bluma Brenner , Michel Roger , David A. Stephens

In this paper, we introduce a novel and interpretable methodology to cluster subjects suffering from cancer, based on features extracted from their biopsies. Contrary to existing approaches, we propose here to capture complex patterns in…

Quantitative Methods · Quantitative Biology 2020-07-07 Yassine El Ouahidi , Matis Feller , Matthieu Talagas , Bastien Pasdeloup

Understanding both global and layer-specific group structures is useful for uncovering complex patterns in networks with multiple interaction types. In this work, we introduce a new model, the hierarchical multiplex stochastic blockmodel…

Inspired by the human ability to learn and organize knowledge into hierarchical taxonomies with prototypes, this paper addresses key limitations in current deep hierarchical clustering methods. Existing methods often tie the structure to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Zekun Wang , Ethan Haarer , Tianyi Zhu , Zhiyi Dai , Christopher J. MacLellan

In biomedical research, to obtain more accurate prediction results from a target study, leveraging information from multiple similar source studies is proved to be useful. However, in many biomedical applications based on real-world data,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Jie Hu , Naimin Jing , Yang Ning , Cheng Yong Tang , Runze Li , Yong Chen