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The paper proposes a time-adaptive optimization approach for determining the time-dependent immune response function in a mathematical model of acute HIV infection, using clinical data from four untreated patients. We formulate the problem…

Numerical Analysis · Mathematics 2025-08-19 L. Beilina , I. Gainova , G. Bocharov

The study of social networks, and in particular the spread of disease on networks, has attracted considerable recent attention in the physics community. In this paper, we show that a large class of standard epidemiological models, the…

Statistical Mechanics · Physics 2007-05-23 M. E. J. Newman

In this article, we consider an HIV/AIDS epidemic model with four classes of individuals. We have discussed about basic properties of the system and found the basic reproduction number $R_0$ of the system. The stability analysis of the…

Dynamical Systems · Mathematics 2023-04-18 Nouar Chorfi , Salem Abdelmalek , Samir Bendoukha

Many pathogens spread primarily via direct contact between infected and susceptible hosts. Thus, the patterns of contacts or contact network of a population fundamentally shapes the course of epidemics. While there is a robust and growing…

Populations and Evolution · Quantitative Biology 2012-08-01 Shweta Bansal , Lauren Ancel Meyers

The human body has a very effective Immune system used to protect the body from dangerous foreign pathogens. This paper aims at studying the immunology and understanding how it works, it also shaded light on the usage of the immunology…

Networking and Internet Architecture · Computer Science 2017-07-25 Almotasem Bellah Alajlouni

This study examines how contact network topology influences the effectiveness of vaccination programs in the context of human papillomavirus (HPV) transmission. Using the SeCoNet sexual contact network growth model, we evaluate age based,…

Social and Information Networks · Computer Science 2025-11-17 Weiyi Wang , Mahendra Piraveenan

Epidemic spreading of infectious diseases is ubiquitous and has often considerable impact on public health and economic wealth. The large variability in spatio-temporal patterns of epidemics prohibits simple interventions and demands for a…

Populations and Evolution · Quantitative Biology 2010-11-25 Christel Kamp

We introduce an immunization method where the percentage of required vaccinations for immunity are close to the optimal value of a targeted immunization scheme of highest degree nodes. Our strategy retains the advantage of being purely…

Physics and Society · Physics 2009-11-13 Lazaros K. Gallos , Fredrik Liljeros , Panos Argyrakis , Armin Bunde , Shlomo Havlin

Interventions are made in networks to change the network or its values in a desired way. The intervention strategies evaluated in the study described here use network sampling designs to find units to which interventions are applied. An…

Methodology · Statistics 2015-11-23 Steven K. Thompson

Understanding how the network topology affects the spread of an epidemic is a main concern in order to develop efficient immunization strategies. While there is a great deal of work dealing with the macroscopic topological properties of the…

Social and Information Networks · Computer Science 2023-01-02 Debayan Chakraborty , Anurag Singh , Hocine Cherifi

The topic of finding effective strategy to halt virus in complex network is of current interest. We propose an immunization strategy for seasonal epidemics that occur periodically. Based on the local information of the infection status from…

Applications · Statistics 2015-06-22 Shu Yan , Shaoting Tang , Sen Pei , Shijin Jiang , Zhiming Zheng

In this work, we study an epidemic model with vaccination coupled with opinion dynamics in a dynamic network. The network structure evolves as agents with differing opinions disconnect from one another and connect with agents that share…

Physics and Society · Physics 2024-01-04 Andre Oestereich , Marcelo Pires , Nuno Crokidakis , Daniel Cajueiro

We investigate the effects of modular and temporal connectivity patterns on epidemic spreading. To this end, we introduce and analytically characterise a model of time-varying networks with tunable modularity. Within this framework, we…

Physics and Society · Physics 2017-10-05 Matthieu Nadini , Kaiyuan Sun , Enrico Ubaldi , Michele Starnini , Alessandro Rizzo , Nicola Perra

$\textbf{Background:}$ High mutability of HIV is the driving force of antiretroviral drug resistance, which represents a medical care challenge. $\textbf{Method and Model Equation:}$ To detect the mutability of each gene in the HIV-1…

Other Quantitative Biology · Quantitative Biology 2019-11-11 Eslam Abbas

In recent years, social media has become a ubiquitous and integral part of social networking. One of the major attentions made by social researchers is the tendency of like-minded people to interact with one another in social groups, a…

Social and Information Networks · Computer Science 2020-08-25 Kazi Zainab Khanam , Gautam Srivastava , Vijay Mago

In this paper we generalise a simple discrete time stochastic SIR type model defined by Tuckwell and Williams. The SIR model by Tuckwell and Williams assumes a homogeneous population, a fixed infectious period, and a strict transition from…

Populations and Evolution · Quantitative Biology 2025-04-21 Carles Rovira

Complete understanding of the mechanisms regulating the proliferation and differentiation that takes place during human immune CD8+ T cell responses is still lacking. Human clinical data is usually limited to blood cell counts, yet the…

Cell Behavior · Quantitative Biology 2018-02-15 John Paul Gosling , Sheeja M. Krishnan , Grant Lythe , Benny Chain , Cameron MacKay , Carmen Molina-París

Molecular HIV Surveillance (MHS) has been described as key to enabling rapid responses to HIV outbreaks. It operates by linking individuals with genetically similar viral sequences, which forms a network. A major limitation of MHS is that…

Applications · Statistics 2024-07-24 Ravi Goyal , Kevin Nguyen , Victor De Gruttola , Susan J Little , Colby Cohen , Natasha K Martin

Epidemic threshold is one of the most important features of the epidemic dynamics. Through a lot of numerical simulations in classic Susceptible-Infected-Recovered (SIR) and Susceptible-Infected-Susceptible (SIS) models on various types of…

Physics and Society · Physics 2014-10-16 Panpan Shu , Wei Wang , Ming Tang , Younghae Do

The power of any kind of network approach lies in the ability to simplify a complex system so that one can better understand its function as a whole. Sometimes it is beneficial, however, to include more information than in a simple graph of…

Physics and Society · Physics 2015-09-21 Petter Holme