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We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected…

Optimization and Control · Mathematics 2022-01-26 Karam Allali , Sanaa Harroudi , Delfim F. M. Torres

It is widely known that the spread of the HIV virus was slower than exponential in several populations, even at the very beginning of the epidemic. We show that this implies a significant reduction in the effective reproductive rate of the…

Populations and Evolution · Quantitative Biology 2007-05-23 Balázs Szendröi , Gábor Csányi

Mathematical modeling and analysis can provide insight on the dynamics of ecosystems which maintain biodiversity in the face of competitive and prey-predator interactions. Of primary interests are the underlying structure and features which…

Populations and Evolution · Quantitative Biology 2017-01-03 Cameron J. Browne

The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations…

Populations and Evolution · Quantitative Biology 2018-02-23 Cameron J. Browne , Hal L. Smith

In this article, we propose a network spread model for HIV epidemics, wherein each individual is represented by a node of the transmission network and the edges are the connections between individuals along which the infection may spread.…

Biological Physics · Physics 2007-08-29 Wen-Jie Bai , Tao Zhou , Bing-Hong Wang

Network immunization is an extensively recognized issue in several domains like virtual network security, public health and social media, to deal with the problem of node inoculation so as to minimize the transmission through the links…

Social and Information Networks · Computer Science 2019-01-03 Chandni Saxena , M. N. Doja , Tanvir Ahmad

A social (sexual) network is modeled by an extension of the configuration model to the situation where edges have weights, e.g. reflecting the number of sex-contacts between the individuals. An epidemic model is defined on the network such…

Probability · Mathematics 2011-12-21 Tom Britton , David Lindenstrand

The vast majority of strategies aimed at controlling contagion processes on networks considers the connectivity pattern of the system as either quenched or annealed. However, in the real world many networks are highly dynamical and evolve…

Physics and Society · Physics 2015-06-17 Suyu Liu , Nicola Perra , Marton Karsai , Alessandro Vespignani

The role of T-cells within the immune system is to confirm and assess anomalous situations and then either respond to or tolerate the source of the effect. To illustrate how these mechanisms can be harnessed to solve real-world problems, we…

Artificial Intelligence · Computer Science 2010-07-05 Jungwon Kim , William Wilson , Uwe Aickelin , Julie McLeod

We consider a simple deterministic model which describes an asymmetric competition between an immune system with a specific and powerful response, and a virus with a broad toxicity and fast mutations. Interest in this model relies on the…

Quantitative Methods · Quantitative Biology 2011-01-17 Thierry Gobron , Mario Santoro , Livio Triolo

The spread of certain diseases can be promoted, in some cases substantially, by prior infection with another disease. One example is that of HIV, whose immunosuppressant effects significantly increase the chances of infection with other…

Physics and Society · Physics 2014-08-04 M. E. J. Newman , C. R. Ferrario

Real epidemic spreading networks often composed of several kinds of networks interconnected with each other, and the interrelated networks have the different topologies and epidemic dynamics. Moreover, most human diseases are derived from…

Physics and Society · Physics 2017-06-21 Zhongpu Xu , Xinchu Fu

In [Math. Comput. Sci. 12 (2018), no. 2, 111--127], a delayed model describing the dynamics of the Human Immunodeficiency Virus (HIV) with Cytotoxic T Lymphocytes (CTL) immune response is investigated by Allali, Harroudi and Torres. Here,…

Dynamical Systems · Mathematics 2022-10-03 Sandra Vaz , Delfim F. M. Torres

Information dissemination intricately intertwines with the dynamics of infectious diseases in the contemporary interconnected world. Recognizing the critical role of public awareness, individual vaccination choices appear to be an essential…

Physics and Society · Physics 2024-10-30 Viney Kumar , Chris T Bauch , Samit Bhattacharyya

Treating and preventing Human Immunodeficiency Virus (HIV) remains a critical global health challenge. While antiretroviral therapy provides a path toward viral suppression -- effectively eliminating an individual's transmission risk --…

Physics and Society · Physics 2026-05-21 Akseli Kangaslahti , Davin Choo , Milind Tambe , Alastair van Heerden , Cheryl Johnson

We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…

Optimization and Control · Mathematics 2018-03-19 Diana Rocha , Cristiana J. Silva , Delfim F. M. Torres

Motivated by massive outbreaks of COVID-19 that occurred even in populations with high vaccine uptake, we propose a novel multi-population temporal network model for the spread of recurrent epidemic diseases. We study the effect of human…

Dynamical Systems · Mathematics 2022-09-19 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

As the global HIV pandemic enters its fourth decade, increasing numbers of surveillance sites have been established which allows countries to look into the epidemics at a finer scale, e.g. at sub-national level. However, the epidemic models…

Applications · Statistics 2014-11-18 Le Bao , Mary Mahy , Xiaoyue Niu , Tim Brown , Peter Ghys

Although community structure is ubiquitous in complex networks, few works exploit this topological property to control epidemics. In this work, devoted to networks with non-overlapping community structure (i.e, a node belongs to a single…

Social and Information Networks · Computer Science 2018-06-15 Zakariya Ghalmane , Mohammed El Hassouni , Hocine Cherifi

We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network. We analyze a networked version of the…

Social and Information Networks · Computer Science 2013-03-19 Victor M. Preciado , Michael Zargham , Chinwendu Enyioha , Ali Jadbabaie , George Pappas