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Computational models have become an essential part of exploratory protocols in cell biology, as a complement to in vivo or in vitro experiments. These virtual models have the twofold advantage of enabling access to new types of data and…

Medical Physics · Physics 2021-12-20 Maxime Vassaux , Laurent Pieuchot , Karine Anselme , Maxence Bigerelle , Jean-Louis Milan

In this paper, we investigate signatures of topological phase transitions in interacting systems. We show that the key signature is the existence of a topologically protected level crossing, which is robust and sharply defines the…

Strongly Correlated Electrons · Physics 2011-12-08 Christopher N. Varney , Kai Sun , Marcos Rigol , Victor Galitski

In traditional topology optimization, the computing time required to iteratively update the material distribution within a design domain strongly depends on the complexity or size of the problem, limiting its application in real engineering…

Computational Engineering, Finance, and Science · Computer Science 2024-05-14 Gabriel Garayalde , Matteo Torzoni , Matteo Bruggi , Alberto Corigliano

Tumors initiate when a population of proliferating cells accumulates a certain number and type of genetic and/or epigenetic alterations. The population dynamics of such sequential acquisition of (epi)genetic alterations has been the topic…

Populations and Evolution · Quantitative Biology 2015-04-09 Peter Ashcroft , Franziska Michor , Tobias Galla

Advances in the next generation of mesoscopic electronics require an understanding of topological phases in inhomogeneous media and the principles that govern them. Motivated by the nature of motifs available in printable conducting inks,…

Mesoscale and Nanoscale Physics · Physics 2026-01-16 Nirnoy Basak , Ritajit Kundu , Basudeb Mondal , Adhip Agarwala

In a system of many similar self-propelled entities such as flocks of birds, fish school, cells and molecules, the interactions with neighbors can lead to a "coherent state", meaning the formation of visually compelling aggregation patterns…

Applications · Statistics 2024-03-07 Thevasha Sathiyakumar , Shantanu Sur , Sumona Mondal , Marko Budišić

In recent years, multimodal medical data-based survival analysis has attracted much attention. However, real-world datasets often suffer from the problem of incomplete modality, where some patient modality information is missing due to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Yi Yin , Yuntao Shou , Zao Dai , Yun Peng , Tao Meng , Wei Ai , Keqin Li

We use Topological Data Analysis tools for studying the inner organization of cells in segmented images of epithelial tissues. More specifically, for each segmented image, we compute different persistence barcodes, which codify lifetime of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-11 N. Atienza , M. J. Jimenez , M. Soriano-Trigueros

The number of observable degrees of freedom is typically limited in experiments. Here, we consider discrete Markov networks in which an observer has access to a few visible transitions and the waiting times between these transitions.…

Statistical Mechanics · Physics 2025-09-26 Alexander M. Maier , Udo Seifert , Jann van der Meer

Classical topological concepts are applied to understand high performance computing simulations of molecules writhing in three dimensional space. These simulations produce peta-bytes of floating point data, to describe 3 dimensional changes…

Geometric Topology · Mathematics 2013-04-23 J. Li , T. J. Peters , K. E. Jordan

Topologically ordered phase has emerged as one of most exciting concepts that not only broadens our understanding of phases of matter, but also has been found to have potential application in fault-tolerant quantum computation. The direct…

Quantum Physics · Physics 2016-06-01 Zhihuang Luo , Chao Lei , Jun Li , Xinfang Nie , Zhaokai Li , Xinhua Peng , Jiangfeng Du

Topological photonic systems offer light transport that is robust against defects and disorder, promising a new generation of chip-scale photonic devices and facilitating energy-efficient on-chip information routing and processing. However,…

Circuit topology refers to the arrangement of interactions between objects belonging to a linearly ordered object set. Linearly ordered set of objects are common in nature and occur in a wide range of applications in economics, computer…

Disordered Systems and Neural Networks · Physics 2015-09-02 Alireza Mashaghi , Abolfazl Ramezanpour

Our understanding of topological insulators is based on an underlying crystalline lattice where the local electronic degrees of freedom at different sites hybridize with each other in ways that produce nontrivial band topology, and the…

Mesoscale and Nanoscale Physics · Physics 2017-10-03 Adhip Agarwala , Vijay B. Shenoy

Models for RNA secondary structures (the topology of folded RNA) without pseudo knots are disordered systems with a complex state-space below a critical temperature. Hence, a complex dynamical (glassy) behavior can be expected, when…

Disordered Systems and Neural Networks · Physics 2008-02-02 S. Wolfsheimer , B. Burghardt , A. Mann , A. K. Hartmann

The Mapper algorithm, a technique within topological data analysis (TDA), constructs a simplified graphical representation of high-dimensional data to uncover its underlying shape and structural patterns. The algorithm has attracted…

General Topology · Mathematics 2025-04-15 Vine Nwabuisi Madukpe , Bright Chukwuma Ugoala , Nur Fariha Syaqina Zulkepli

A density-based topology optimization framework is developed to manipulate characteristic modes of conducting surfaces. The adjoint sensitivity analysis provides an efficient computation of the material gradient utilized by the local…

Optimization and Control · Mathematics 2025-02-07 Jonas Tucek , Miloslav Capek , Lukas Jelinek

The kinetics of collective rearrangements in solution, such as protein folding and nanocrystal phase transitions, often involve free energy barriers that are both long and rough. Applying methods of transition path sampling to harvest…

Statistical Mechanics · Physics 2009-11-13 M. Grünwald , P. L. Geissler , C. Dellago

Stochastic modeling has become a popular approach to quantify uncertainty in flows through heterogeneous porous media. The uncertainty in heterogeneous structure properties is often parameterized by a high-dimensional random variable. This…

Numerical Analysis · Mathematics 2013-10-22 Lijian Jiang , J. David Moulton , Jia Wei

We present a braided circuit topology framework for investigating topology and structural phase transitions in aggregates of semiflexible polymers. In the conventional approach to circuit topology, which specifically applies to single…

Soft Condensed Matter · Physics 2024-02-27 Jonas Berx , Alireza Mashaghi