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Consider a two-treatment, two-period crossover trial, with responses that are continuous random variables. We find a large-sample frequentist 1-alpha confidence interval for the treatment difference that utilizes the uncertain prior…

Methodology · Statistics 2011-09-27 Paul Kabaila , Khageswor Giri

Measurements are generally collected as unilateral or bilateral data in clinical trials or observational studies. For example, in ophthalmology studies, the primary outcome is often obtained from one eye or both eyes of an individual. In…

Methodology · Statistics 2021-11-01 Kejia Wang , Chang-Xing Ma

What, if anything, should a frequentist say about a single realized confidence interval (CI) and its chance of having covered the parameter? Jerzy Neyman's original answer was to refuse any nondegenerate probability for coverage ex post…

Other Statistics · Statistics 2026-03-06 Scott Lee

Consider a linear regression model with regression parameter beta=(beta_1,..., beta_p) and independent normal errors. Suppose the parameter of interest is theta = a^T beta, where a is specified. Define the s-dimensional parameter vector tau…

Statistics Theory · Mathematics 2017-10-18 Paul Kabaila , Davide Farchione

Selective inference is the problem of giving valid answers to statistical questions chosen in a data-driven manner. A standard solution to selective inference is simultaneous inference, which delivers valid answers to the set of all…

Methodology · Statistics 2024-05-03 Tijana Zrnic , William Fithian

We present a novel and easy-to-use method for calibrating error-rate based confidence intervals to evidence-based support intervals. Support intervals are obtained from inverting Bayes factors based on a parameter estimate and its standard…

Methodology · Statistics 2023-06-28 Samuel Pawel , Alexander Ly , Eric-Jan Wagenmakers

Fourier transform has become a basic tool for analyzing biological signals 1,2,3. Mostly a fast Fourier transform is computed for a finite sequence of data sample 4. This is the standard way apparatuses and modern computerized technology…

Quantitative Methods · Quantitative Biology 2008-04-01 Silvia Solis Ortiz , Rafael G. Campos , Julian Felix , Octavio Obregon

Corrected confidence intervals are developed for the mean of the second component of a bivariate normal process when the first component is being monitored sequentially. This is accomplished by constructing a first approximation to a…

Statistics Theory · Mathematics 2007-06-13 R. C. Weng , D. S. Coad

We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs allow the enrolled population to be modified at an interim…

Methodology · Statistics 2026-03-17 Enyu Li , Nigel Stallard , Ekkehard Glimm , Dominic Magirr , Peter K. Kimani

The proposed approach extends the confidence posterior distribution to the semi-parametric empirical Bayes setting. Whereas the Bayesian posterior is defined in terms of a prior distribution conditional on the observed data, the confidence…

Methodology · Statistics 2012-05-02 David R. Bickel

A new method is proposed for the correction of confidence intervals when the original interval does not have the correct nominal coverage probabilities in the frequentist sense. The proposed method is general and does not require any…

Computation · Statistics 2013-08-30 P. Menendez , Y. Fan , P. H. Garthwaite , S. A. Sisson

Quantifying uncertainty using confidence regions is a central goal of statistical inference. Despite this, methodologies for confidence bands in Functional Data Analysis are still underdeveloped compared to estimation and hypothesis…

Methodology · Statistics 2022-11-14 Dominik Liebl , Matthew Reimherr

Parameters of sub-populations can be more relevant than super-population ones. For example, a healthcare provider may be interested in the effect of a treatment plan for a specific subset of their patients; policymakers may be concerned…

Methodology · Statistics 2023-03-22 Ying Jin , Dominik Rothenhäusler

Simultaneous confidence intervals (SCIs) that are compatible with a given closed test procedure are often non-informative. More precisely, for a one-sided null hypothesis, the bound of the SCI can stick to the border of the null hypothesis,…

Methodology · Statistics 2024-06-25 Werner Brannath , Liane Kluge , Martin Scharpenberg

Many scientific analyses require simultaneous comparison of multiple functionals of an unknown signal at once, calling for multidimensional confidence regions with guaranteed simultaneous frequentist under structural constraints (e.g.,…

Statistics Theory · Mathematics 2025-10-14 Pau Batlle , Pratik Patil , Michael Stanley , Javier Ruiz Lupon , Houman Owhadi , Mikael Kuusela

A/B tests are typically analyzed via frequentist p-values and confidence intervals; but these inferences are wholly unreliable if users endogenously choose samples sizes by *continuously monitoring* their tests. We define *always valid*…

Statistics Theory · Mathematics 2019-07-18 Ramesh Johari , Leo Pekelis , David J. Walsh

Uncertainty quantification for estimation through stochastic optimization solutions in an online setting has gained popularity recently. This paper introduces a novel inference method focused on constructing confidence intervals with…

Machine Learning · Statistics 2026-03-24 Wanrong Zhu , Zhipeng Lou , Ziyang Wei , Wei Biao Wu

By employing various empirical estimators for the Mutual Information (MI) measure, we calculate and compare the estimates and their confidence intervals for both normal and non-normal bivariate data samples. We find that certain nonlinear…

Information Theory · Computer Science 2024-10-10 Theo Grigorenko , Leo Grigorenko

Tolerance limits have received considerable attention in the statistical literature, with applications reaching far beyond their initial role in quality control. The well-known formula of Scheff\'e and Tukey (1944) establishes a simple,…

Methodology · Statistics 2026-05-20 James H. McVittie , Martin Lysy , Masoud Asgharian

Data following an interval structure are increasingly prevalent in many scientific applications. In medicine, clinical events are often monitored between two clinical visits, making the exact time of the event unknown and generating…

Methodology · Statistics 2025-04-01 Carlos García Meixide , Michael R. Kosorok , Marcos Matabuena