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Motivated by observations of the dynamics of {\it Myxococcus xanthus}, we present a self-interacting random walk model that describes the competition between chemokinesis and chemotaxis. Cells are constrained to move in one dimension, but…

Statistical Mechanics · Physics 2016-08-31 Maria R. D'Orsogna , Marc Suchard , Tom Chou

Chemotactic cells establish cell polarity in the absence of external guidance cues. Such self-organized polarity is induced by spontaneous symmetry breaking in the intracellular activities, which produces an emergent memory effect…

Cell Behavior · Quantitative Biology 2015-06-16 Tetsuya Hiraiwa , Akihiro Nagamatsu , Naohiro Akuzawa , Masatoshi Nishikawa , Tatsuo Shibata

This work concerns with a class of chemotaxis models in which external sources, comprising nonlocal and gradient-dependent damping reactions, influence the motion of a cell density attracted by a chemical signal. The mechanism of the two…

Analysis of PDEs · Mathematics 2024-06-17 Rafael Díaz Fuentes , Silvia Frassu , Giuseppe Viglialoro

The purpose of this work is to propose a nonlinear non-Markovian model of subdiffusive transport that involves chemotactic substance affecting the cells at all time, not only during the jump. This leads the random waiting time to be…

Statistical Mechanics · Physics 2016-04-12 Akram Al-Sabbagh

Chemical signaling is one of the ubiquitous mechanisms by which inter-cellular communication takes place at the microscopic level, particularly via chemotaxis. Such multi-cellular systems are popularly studied using continuum, mean-field…

Cell Behavior · Quantitative Biology 2009-11-11 Ramon Grima

Chemotaxis refers to the directed movement of cells in response to a chemical signal called chemoattractant. A crucial point in the mathematical modeling of chemotactic processes is the correct description of the chemotactic sensitivity and…

Analysis of PDEs · Mathematics 2015-01-08 Herbert Egger , Jan-Frederik Pietschmann , Matthias Schlottbom

Background: Living cells of many types need to move in response to external stimuli in order to accomplish their functional tasks; these tasks range from wound healing to immune response to fertilization. While the directional motion is…

Cell Behavior · Quantitative Biology 2015-05-28 Inbal Hecht , Herbert Levine , Wouter-Jan Rappel , Eshel Ben-Jacob

The purpose of this work is the study of \textit{chemotaxis} and how to model it through the equations of Keller-Segel. \textit{Chemotaxis} is a natural process which induces the organisms to direct their movement according to certain…

Analysis of PDEs · Mathematics 2021-11-24 Alejandro Fernández-Jiménez

Many biological microswimmers are capable of chemotaxis, i.e., they can sense an ambient chemical gradient and adjust their mechanism of motility to move towards or away from the source of the gradient. Synthetic active colloids endowed…

Soft Condensed Matter · Physics 2024-06-18 Viviana Mancuso , Mihail N. Popescu , William E. Uspal

Motivated by the observation of non-exponential run-time distributions of bacterial swimmers, we propose a minimal phenomenological model for taxis of active particles whose motion is controlled by an internal clock. The ticking of the…

Biological Physics · Physics 2020-07-23 Luis Gómez Nava , Robert Großmann , Marius Hintsche , Carsten Beta , Fernando Peruani

Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…

Cell Behavior · Quantitative Biology 2015-12-09 Gabriele Micali , Robert G. Endres

We investigate single-cell directional sensing from diffusing chemoattractant signals released by a localized source. We focus on the low-concentration regime in which receptor activity is discrete and cellular decisions are made on…

Cell Behavior · Quantitative Biology 2026-03-12 Vincent Fiorino , Sean D. Lawley , Alan E. Lindsay

In modeling the inflammatory response to a lesion in an artery wall, there are a number of chemotactic mechanisms going on within the wall layer that lead to an arterial plaque. We introduce a rather reduced model of these dynamic…

Analysis of PDEs · Mathematics 2015-11-10 Jonathan Bell , Animikh Biswas

Many phenomena in biology involve both reactions and chemotaxis. These processes can clearly influence each other, and chemotaxis can play an important role in sustaining and speeding up the reaction. In continuation of our earlier work, we…

Analysis of PDEs · Mathematics 2015-06-04 Alexander Kiselev , Lenya Ryzhik

Chemotaxis is a fundamental mechanism of cells and organisms, which is responsible for attracting microbes to food, embryonic cells into developing tissues, or immune cells to infection sites. Mathematically chemotaxis is described by the…

Analysis of PDEs · Mathematics 2020-09-30 Erika Hausenblas , Debopriya Mukherjee , Thanh Tran

Chemotaxis and haptotaxis have been a main theme in the macroscopic study of bacterial and cellular motility. In this work we investigate the influence these processes have on the shape and motility of fast migrating cells. We note that…

Cell Behavior · Quantitative Biology 2016-12-08 Aaron Brunk , Niklas Kolbe , Nikolaos Sfakianakis

The large scale behaviour of a population of cells that grow and interact through the concentration field of the chemicals they secrete is studied using dynamical renormalization group methods. The combination of the effective long-range…

Cell Behavior · Quantitative Biology 2015-01-19 Anatolij Gelimson , Ramin Golestanian

Chemotaxis along helical paths towards a target releasing a chemoattractant is found in sperm cells and many microorganisms. We discuss the stochastic differential geometry of the noisy helical swimming path of a chiral swimmer. A chiral…

Biological Physics · Physics 2010-09-28 Benjamin M. Friedrich , Frank Jülicher

We introduce mesoscopic and macroscopic model equations of chemotaxis with anomalous subdiffusion for modelling chemically directed transport of biological organisms in changing chemical environments with diffusion hindered by traps or…

Dynamical Systems · Mathematics 2012-12-03 T. A. M. Langlands , B. I. Henry

Immune cells have evolved to recognize and eliminate pathogens, and the efficiency of this process can be measured in a Petri dish. Yet, even if the cells are time-lapse recorded and tracked with high resolution, it is difficult to judge…

Quantitative Methods · Quantitative Biology 2019-06-21 Claus Metzner