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Empirical research plays a fundamental role in the machine learning domain. At the heart of impactful empirical research lies the development of clear research hypotheses, which then shape the design of experiments. The execution of…

Machine Learning · Computer Science 2024-05-29 Daniel Vranješ , Oliver Niggemann

The ability to learn and act in novel situations is still a prerogative of animate intelligence, as current machine learning methods mostly fail when moving beyond the standard i.i.d. setting. What is the reason for this discrepancy? Most…

Machine Learning · Computer Science 2018-12-04 Niki Kilbertus , Giambattista Parascandolo , Bernhard Schölkopf

Robust causal discovery from observational data under imperfect prior knowledge remains a significant and largely unresolved challenge. Existing methods typically presuppose perfect priors or can only handle specific, pre-identified error…

Machine Learning · Computer Science 2025-11-11 Zidong Wang , Xi Lin , Chuchao He , Xiaoguang Gao

Estimation frameworks for statistical inference are preferred to hypothesis testing when quantifying uncertainty and precise estimation are more valuable than binary decisions about statistical significance. Study design for…

Methodology · Statistics 2025-10-29 Luke Hagar , Nathaniel T. Stevens

Causal machine learning has the potential to revolutionize decision-making by combining the predictive power of machine learning algorithms with the theory of causal inference. However, these methods remain underutilized by the broader…

A predictive model makes outcome predictions based on some given features, i.e., it estimates the conditional probability of the outcome given a feature vector. In general, a predictive model cannot estimate the causal effect of a feature…

Machine Learning · Computer Science 2023-04-11 Jiuyong Li , Lin Liu , Ziqi Xu , Ha Xuan Tran , Thuc Duy Le , Jixue Liu

Unobserved confounding is one of the main challenges when estimating causal effects. We propose a causal reduction method that, given a causal model, replaces an arbitrary number of possibly high-dimensional latent confounders with a single…

Machine Learning · Statistics 2023-02-24 Maximilian Ilse , Patrick Forré , Max Welling , Joris M. Mooij

Causal inference with observational studies often relies on the assumptions of unconfoundedness and overlap of covariate distributions in different treatment groups. The overlap assumption is violated when some units have propensity scores…

Methodology · Statistics 2022-07-19 Shu Yang , Peng Ding

Traditional approaches to data visualization have often focused on comparing different subsets of data, and this is reflected in the many techniques developed and evaluated over the years for visual comparison. Similarly, common workflows…

Human-Computer Interaction · Computer Science 2024-02-27 David Borland , Arran Zeyu Wang , David Gotz

We discuss recent work for causal inference and predictive robustness in a unifying way. The key idea relies on a notion of probabilistic invariance or stability: it opens up new insights for formulating causality as a certain risk…

Methodology · Statistics 2018-12-21 Peter Bühlmann

Sound educational policy recommendations require valid estimates of causal effects, but observational studies in physics education research sometimes have loosely specified causal hypotheses. The connections between the observational data…

Physics Education · Physics 2021-09-22 M. B. Weissman

Estimating causal effects under exogeneity hinges on two key assumptions: unconfoundedness and overlap. Researchers often argue that unconfoundedness is more plausible when more covariates are included in the analysis. Less discussed is the…

Statistics Theory · Mathematics 2020-01-06 Alexander D'Amour , Peng Ding , Avi Feller , Lihua Lei , Jasjeet Sekhon

In causal inference, principal stratification is a framework for dealing with a posttreatment intermediate variable between a treatment and an outcome, in which the principal strata are defined by the joint potential values of the…

Methodology · Statistics 2021-04-20 Zhichao Jiang , Peng Ding

We consider basic conceptual questions concerning the relationship between statistical estimation and causal inference. Firstly, we show how to translate causal inference problems into an abstract statistical formalism without requiring any…

Statistics Theory · Mathematics 2020-07-22 Oliver J. Maclaren , Ruanui Nicholson

The majority of historical designs are a priori in nature, where a priori indicates a design can be specified in advance of the experiment. The conventional wisdom is that the set of a priori designs is sufficient to produce efficient…

Methodology · Statistics 2022-06-22 Adam Lane

Prior probabilities of clinical hypotheses are not systematically used for clinical trial design yet, due to a concern that poor priors may lead to poor decisions. To address this concern, a conservative approach to Bayesian trial design is…

Methodology · Statistics 2023-09-21 Fabio Rigat

Study designs classified as quasi- or natural experiments are typically accorded more face validity than observational study designs more broadly. However, there is ambiguity in the literature about what qualifies as a quasi-experiment.…

Methodology · Statistics 2025-08-20 Audrey Renson , Daniel Westreich

As artificial intelligence and machine learning tools become more accessible, and scientists face new obstacles to data collection (e.g., rising costs, declining survey response rates), researchers increasingly use predictions from…

Machine Learning · Statistics 2025-12-08 Stephen Salerno , Kentaro Hoffman , Awan Afiaz , Anna Neufeld , Tyler H. McCormick , Jeffrey T. Leek

Observational studies are valuable for estimating the effects of various medical interventions, but are notoriously difficult to evaluate because the methods used in observational studies require many untestable assumptions. This lack of…

Applications · Statistics 2022-09-14 Ethan Steinberg , Nikolaos Ignatiadis , Steve Yadlowsky , Yizhe Xu , Nigam H. Shah

In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the…

Machine Learning · Statistics 2022-06-08 Susan Athey , Guido Imbens