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Current optical detection schemes for single molecules require light absorption, either to produce fluorescence or direct absorption signals. This severely limits the range of molecules that can be detected, because most molecules are…

Chemical Physics · Physics 2012-07-06 Peter Zijlstra , Pedro M. R. Paulo , Michel Orrit

Compton scatter tomography is an emerging technique with attractive applications in several fields in imaging such as non-destructive testing and medical scanning. In this paper, we introduce a novel modality in three dimensions with a…

Numerical Analysis · Mathematics 2022-03-18 Javier Cebeiro , Cecilia Tarpau , Marcela Morvidone , Diana Rubio , Mai Nguyen

Boron arsenide (c-BAs) is at the forefront of research on ultrahigh thermal conductivity materials. We present a Raman scattering study of isotopically tailored cubic boron arsenide single crystals for 11 isotopic compositions spanning the…

Materials Science · Physics 2021-01-27 Akash Rai , Sheng Li , Hanlin Wu , Bing Lv , David G. Cahill

Detecting the photons emitted from single quantum objects is highly desired to diagnose nano-scale devices. It has been, however, believed very difficult to sense single atoms in optical spectroscopy due to the inferior detection…

Mesoscale and Nanoscale Physics · Physics 2015-06-05 Kazu Suenaga , Toshiya Okazaki , Eiji Okunishi , Syo Matsumura

The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…

Quantitative Methods · Quantitative Biology 2024-07-18 Nathan Quiblier , Jan-Michael Rye , Pierre Leclerc , Henri Truong , Abdelkrim Hannou , Laurent Héliot , Hugues Berry

As a highly sensitive vibrational imaging method, stimulated Raman scattering (SRS) microscopy is finding various applications, while its theoretical treatment seems still under development. Here we present a theoretical estimation of…

Optics · Physics 2024-03-11 Yasuyuki Ozeki

Stochastic resonance (SR) is a well known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic noise. Here we carry out the first experimental study of SR in…

Biological Physics · Physics 2012-12-12 K. Hayashi , S. de Lorenzo , M. Manosas , J. M. Huguet , F. Ritort

Spectroscopic analysis of large biomolecules is critical in a number of applications, including medical diagnostics and label-free biosensing. Recently, it has been shown that Raman spectroscopy of proteins can be used to diagnose some…

Molybdenum disulfide (MoS2) of single and few-layer thickness was exfoliated on SiO2/Si substrate and characterized by Raman spectroscopy. The number of S-Mo-S layers of the samples was independently determined by contact-mode atomic-force…

Materials Science · Physics 2010-11-16 Changgu Lee , Hugen Yan , Louis E. Brus , Tony F. Heinz , James Hone , Sunmin Ryu

We explain quantitatively why resonant Raman scattering spectroscopy, an extensively used experimental tool in studying elementary electronic excitations in doped low dimensional semiconductor nanostructures, always produces an observable…

Strongly Correlated Electrons · Physics 2009-10-31 S. Das Sarma , Daw-Wei Wang

Airborne contaminants, e.g., bacterial spores, are usually analyzed by time consuming microscopic, chemical and biological assays. Current research into real time laser spectroscopic detectors of such contaminants is based on e.g. resonant…

Optical spectroscopy and imaging of microscopic samples have opened up a wide range of applications throughout the physical, chemical, and biological sciences. High chemical specificity may be achieved by directly interrogating the…

We discuss the effect of the local field polarization in metallic nanostructures where large field enhancements can be induced by excitation of localized surface plasmons. To demonstrate the importance of these effects, we study a few model…

Chemical Physics · Physics 2007-05-23 E. C. Le Ru , P. G. Etchegoin

This article reviews the new developments in Tip-enhanced Raman scattering (TERS). The fundamental mechanisms underlying the Raman enhancement are discussed, including the role of the plasmonic character of the metallic tips, the nature of…

Chemical Physics · Physics 2008-04-01 Catalin C. Neacsu , Samuel Berweger , Markus B. Raschke

We propose and demonstrate a novel technique that combines Raman scattering and optical cycling in molecules with diagonal Franck-Condon factors. This resonance Raman optical cycling manipulates molecules to behave like efficient…

Atomic Physics · Physics 2021-08-26 J. C. Shaw , J. C. Schnaubelt , D. J. McCarron

In situ measurement of cellular metabolites is still a challenge in biology. Conventional methods, such as mass spectrometry or fluorescence microscopy, would either destruct the sample or introduce strong perturbations to the functions of…

Quantitative Methods · Quantitative Biology 2019-12-19 Kai-Chih Huang , Junjie Li , Chi Zhang , Yuying Tan , Ji-Xin Cheng

We explore theoretically the electroluminescence of single molecules. We adopt a local-electrode framework that is appropriate for scanning tunneling microscopy (STM) experiments where electroluminescence originates from individual…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 John Buker , George Kirczenow

Propagation of light in a highly scattering medium is among the most fascinating optical effect that everyone experiences on an everyday basis and possesses a number of fundamental problems which have yet to be solved. Conventional wisdom…

The vibrational landscape of adsorbed molecules is central to understanding surface interactions at the atomic scale, influencing phenomena from catalysis to molecular electronics. Recent advances in atomic-scale tip-enhanced Raman…

The coupling of an electron monochromator (EM) to a mass spectrometer (MS) has created a new analytical technique, EM-MS, for the investigation of electrophilic compounds. This method provides a powerful tool for molecular identification of…

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