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The relationship between a neuron's complex inputs and its spiking output defines the neuron's coding strategy. This is frequently and effectively modeled phenomenologically by one or more linear filters that extract the components of the…

Neurons and Cognition · Quantitative Biology 2011-11-02 Michael Famulare , Adrienne L. Fairhall

Neural responses are highly variable, and some portion of this variability arises from fluctuations in modulatory factors that alter their gain, such as adaptation, attention, arousal, expected or actual reward, emotion, and local metabolic…

Neurons and Cognition · Quantitative Biology 2015-07-08 Neil C. Rabinowitz , Robbe L. T. Goris , Johannes Ballé , Eero P. Simoncelli

We studied the mutual information between a stimulus and a large system consisting of stochastic, statistically independent elements that respond to a stimulus. The Mutual Information (MI) of the system saturates exponentially with system…

Statistical Mechanics · Physics 2009-11-07 Kukjin Kang , Haim Sompolinsky

Animals learn to predict external contingencies from experience through a process of conditioning. A natural mechanism for conditioning is stimulus substitution, whereby the neuronal response to a stimulus with no prior behavioral…

Neurons and Cognition · Quantitative Biology 2024-09-23 Pantelis Vafidis , Antonio Rangel

Does synchronization between action potentials from different neurons in the visual system play a substantial role in solving the binding problem? The binding problem can be studied quantitatively in the broader framework of the information…

Biological Physics · Physics 2007-05-23 Simon R. Schultz , Huw D. R. Golledge , Stefano Panzeri

Parallel recordings of neural spike counts have revealed the existence of context-dependent noise correlations in neural populations. Theories of population coding have also shown that such correlations can impact the information encoded by…

Machine Learning · Computer Science 2025-07-30 Sacha Sokoloski , Ruben Coen-Cagli

Models of neural responses to stimuli with complex spatiotemporal correlation structure often assume that neurons are only selective for a small number of linear projections of a potentially high-dimensional input. Here we explore recent…

Neurons and Cognition · Quantitative Biology 2013-06-19 Kanaka Rajan , Olivier Marre , Gašper Tkačik

Neural populations encode information about their stimulus in a collective fashion, by joint activity patterns of spiking and silence. A full account of this mapping from stimulus to neural activity is given by the conditional probability…

Neurons and Cognition · Quantitative Biology 2013-06-14 Einat Granot-Atedgi , Gašper Tkačik , Ronen Segev , Elad Schneidman

We consider a threshold-crossing spiking process as a simple model for the activity within a population of neurons. Assuming that these neurons are driven by a common fluctuating input with Gaussian statistics, we evaluate the…

Neurons and Cognition · Quantitative Biology 2009-06-11 Yoram Burak , Sam Lewallen , Haim Sompolinsky

Neural oscillations are universal phenomena and can be observed at different levels of neural systems, from single neuron to macroscopic brain. The frequency of those oscillations are related to the brain functions. However, little is know…

Neurons and Cognition · Quantitative Biology 2015-07-30 Lianchun Yu , Longfei Wang , Fei Jia , Duojie Jia

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

The human brain prioritises relevant sensory information to perform different tasks. Enhancement of task-relevant information requires flexible allocation of attentional resources, but it is still a mystery how this is operationalised in…

Neurons and Cognition · Quantitative Biology 2021-02-22 Tijl Grootswagers , Amanda K. Robinson , Sophia M. Shatek , Thomas A. Carlson

To thrive in dynamic environments, animals must be capable of rapidly and flexibly adapting behavioral responses to a changing context and internal state. Examples of behavioral flexibility include faster stimulus responses when attentive…

Neurons and Cognition · Quantitative Biology 2021-01-27 David Wyrick , Luca Mazzucato

Mammalian spatial navigation relies on specialized neurons, such as place and grid cells, which encode position based on self-motion and environmental cues. While extensive research has explored the computational role of grid cells, the…

Neurons and Cognition · Quantitative Biology 2026-03-02 Jared Deighton , Wyatt Mackey , Ioannis Schizas , David L. Boothe , Vasileios Maroulas

Neurons in the nervous system exhibit an outstanding variety of morphological and physiological properties. However, close to threshold, this remarkable richness may be grouped succinctly into two basic types of excitability, often referred…

Neurons and Cognition · Quantitative Biology 2008-01-28 Germán Mato , Inés Samengo

Spike correlations between neurons are ubiquitous in the cortex, but their role is at present not understood. Here we describe the firing response of a leaky integrate-and-fire neuron (LIF) when it receives a temporarily correlated input…

Neurons and Cognition · Quantitative Biology 2007-10-15 Ruben Moreno-Bote , Alfonso Renart , Nestor Parga

A population of firing neurons is expected to carry information not only by mean firing rate but also by fluctuation and synchrony among neurons. In order to examine this possibility, we have studied responses of neuronal ensembles to three…

Neurons and Cognition · Quantitative Biology 2009-11-13 Hideo Hasegawa

We demonstrate that the information contained in the spike occurrence times of a population of neurons can be broken up into a series of terms, each of which reflect something about potential coding mechanisms. This is possible in the…

Biological Physics · Physics 2007-05-23 S. Panzeri , S. R. Schultz

To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision…

Neurons and Cognition · Quantitative Biology 2018-10-05 Audrey J. Sederberg , Jason N. MacLean , Stephanie E. Palmer

In simple perceptual decisions the brain has to identify a stimulus based on noisy sensory samples from the stimulus. Basic statistical considerations state that the reliability of the stimulus information, i.e., the amount of noise in the…

Neurons and Cognition · Quantitative Biology 2015-09-08 Sebastian Bitzer , Stefan J. Kiebel