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The distinctive characteristics of water, evident in its thermodynamic anomalies, have implications across disciplines from biology to geophysics. Considered a valid hypothesis to rationalize its unique properties, a liquid-liquid phase…

Soft Condensed Matter · Physics 2025-12-08 Maria Grazia Izzo , John Russo , Giorgio Pastore

The supercooled state of bulk water is largely hidden by unavoidable crystallization, which creates an experimentally inaccessible temperature regime - a 'no man's land'. We address this and circumvent the crystallization problem by…

Soft Condensed Matter · Physics 2013-05-29 Johan Mattsson , Rikard Bergman , Per Jacobsson , Lars Börjesson

Recently we have shown experimental evidence for a fragile-to-strong dynamic crossover (FSC) phenomenon in hydration water around a globular protein (lysozyme) at ambient pressure. In this letter we show that when applying pressure to the…

In supercooled liquids, at a temperature between the glass transition temperature Tg and the melting point Tm, thermodynamic properties remain continuous, while dynamic behavior exhibits anomalies. The origin of such thermodynamics-dynamic…

Soft Condensed Matter · Physics 2025-06-17 X. R. Tian , D. M. Zhang , B. Zhang , D. Y. Sun , X. G. Gong

The mechanisms of cold- and pressure-denaturation of proteins are matter of debate and are commonly understood as due to water-mediated interactions. Here we study several cases of proteins, with or without a unique native state, with or…

Biological Physics · Physics 2026-01-13 Valentino Bianco , Giancarlo Franzese

Liquids realize a highly complex state of matter in which strong competing kinetic and interaction effects come to life. As such, liquids are more challenging to understand than either gases or solids generally. In weakly interacting gases,…

Soft Condensed Matter · Physics 2022-06-29 Jing Xue , Flavio S. Nogueira , K. F. Kelton , Zohar Nussinov

Enhanced dynamical fluctuations of RNAs, facilitated by a network of water molecules with strong interactions with RNA, are suspected to be critical in their ability to respond to a variety of cellular signals. Using atomically detailed…

Biomolecules · Quantitative Biology 2015-01-15 Jeseong Yoon , Jong-Chin Lin , Changbong Hyeon , D. Thirumalai

We present a Molecular Dynamics study of the single particle dynamics of supercooled water confined in a silica pore. Two dynamical regimes are found: close to the hydrophilic substrate molecules are below the Mode Coupling crossover…

Statistical Mechanics · Physics 2009-10-31 P. Gallo , M. Rovere , E. Spohr

Water shows numerous thermodynamic, dynamic, and structural anomalies. Recent experiments [Eichler et al. Phys. Rev. Lett. 134, 134101 (2025)], based on measurements of shear and bulk viscosities of liquid water up to 1.6 GPa, have reported…

Soft Condensed Matter · Physics 2026-01-27 José Martín-Roca , Alberto Zaragoza , Frédéric Caupin , Chantal Valeriani

The liquid and supercooled states of water show a series of anomalies whose nature is debated. A key role is attributed to the formation of structural aggregates induced by critical phenomena occurring deep in the supercooled region; the…

Chemical Physics · Physics 2013-12-18 A. Taschin , P. Bartolini , R. Eramo , R. Righini , R. Torre

We review the available experimental information on the thermodynamic properties of supercooled ordinary and heavy water and demonstrate the possibility of modeling these thermodynamic properties on a theoretical basis. We show that by…

Chemical Physics · Physics 2013-02-25 V. Holten , C. E. Bertrand , M. A. Anisimov , J. V. Sengers

Light and heavy water show similar anomalies in thermodynamic and dynamic properties, with a consistent trend of anomalies occurring at higher temperature in heavy water. Viscosity also increases faster upon cooling in heavy water, causing…

Chemical Physics · Physics 2024-05-16 Frédéric Caupin , Pierre Ragueneau , Bruno Issenmann

The Arrhenius crossover temperature, $T_{A}$, corresponds to a thermodynamic state wherein the atomistic dynamics of a liquid becomes heterogeneous and cooperative; and the activation barrier of diffusion dynamics becomes…

Materials Science · Physics 2023-01-31 Bulat N. Galimzyanov , Maria A. Doronina , Anatolii V. Mokshin

We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water density fluctuations on protein stability. We find that above the…

Soft Condensed Matter · Physics 2009-11-07 Manuel I. Marques , Jose M. Borreguero , H. Eugene Stanley , Nikolay V. Dokholyan

We measure the energy exchanged between two hydrodynamically coupled micron-sized Brownian particles trapped in water by two optical tweezers. The system is driven out of equilibrium by random forcing the position of one of the two…

Soft Condensed Matter · Physics 2015-05-27 Antoine Bérut , Artyom Petrosyan , Sergio Ciliberto

A structural transformation in water upon compression was recently observed at the temperature $T=277$~K in the vicinity of the pressure $p \approx 2\;000$~Atm [R.M. Khusnutdinoff, A.V. Mokshin, J. Non-Cryst. Solids \textbf{357}, 1677…

Disordered Systems and Neural Networks · Physics 2015-06-03 Ramil M. Khusnutdinoff , Anatolii V. Mokshin

Water shows anomalous properties that are enhanced upon supercooling. The unusual behavior is observed in both H$_2$O and D$_2$O, however with different temperature dependences for the two isotopes. It is often noted that comparing the…

Chemical Physics · Physics 2024-03-14 Greg A. Kimmel

We examine the behavior of the diffusion coefficient of the ST2 model of water over a broad region of the phase diagram via molecular dynamics simulations. The ST2 model has an accessible liquid-liquid transition between low-density and…

Statistical Mechanics · Physics 2012-08-07 Peter H. Poole , Stephen R. Becker , Francesco Sciortino , Francis W. Starr

Using a combination of dielectric spectroscopy and solid-state deuteron NMR, the hydration water dynamics of connective tissue proteins is studied at sub-ambient temperatures. In this range, the water dynamics follows an Arrhenius law. A…

Soft Condensed Matter · Physics 2015-05-18 Sorin A. Lusceac , Markus Rosenstihl , Michael Vogel , Catalin Gainaru , Ariane Fillmer , Roland Böhmer

The viscosity of supercooled water has been a subject of intense study, in particular with respect to its temperature dependence. Much less is known, however, about the influence of dynamical effects on the viscosity in its supercooled…

Soft Condensed Matter · Physics 2020-04-15 Ingrid de Almeida Ribeiro , Maurice de Koning