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Some systems cannot be predicted by classical theories and it is required the development of combined deterministic and stochastic theories that make used of noise for dynamical prediction. Noise is not always an interfering signal which…

Adaptation and Self-Organizing Systems · Physics 2019-05-14 Alexandra Pinto Castellanos

Biological functions in living cells are controlled by protein interaction and genetic networks. These molecular networks should be dynamically stable against various fluctuations which are inevitable in the living world. In this paper, we…

Molecular Networks · Quantitative Biology 2009-11-13 Yuping Zhang , Minping Qian , Qi Ouyang , Minghua Deng , Fangting Li , Chao Tang

We look into the fluctuations caused by disturbances in power systems. In the linearized system of the power systems, the disturbance is modeled by a Brownian motion process, and the fluctuations are described by the covariance matrix of…

Systems and Control · Electrical Eng. & Systems 2023-03-20 Xian Wu , Kaihua Xi , Aijie Cheng , Hai Xiang Lin , Jan H van Schuppen , Chenghui Zhang

Stochastic reaction-diffusion models can be analytically studied on complex networks using the linear noise approximation. This is illustrated through the use of a specific stochastic model, which displays traveling waves in its…

Statistical Mechanics · Physics 2015-06-16 Malbor Asllani , Tommaso Biancalani , Duccio Fanelli , Alan J. McKane

Quantitative single cell measurements have shown that cell cycle duration (the time between cell divisions) for diverse cell types is a noisy variable. The underlying distribution is mean scalable with a universal shape for many cell types…

Cell Behavior · Quantitative Biology 2016-03-07 Nash Rochman , Fangwei Si , Sean X. Sun

Cells are known to utilize biochemical noise to probabilistically switch between distinct gene expression states. We demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore…

Molecular Networks · Quantitative Biology 2009-11-13 Pankaj Mehta , Ranjan Mukhopadhyay , Ned S. Wingreen

Gene Regulatory Networks(GRNs) with feedback are essential components of many cellular processes and may exhibit oscillatory behavior. Analyzing such systems becomes increasingly complex as the number of components increases. Since gene…

Molecular Networks · Quantitative Biology 2026-04-22 Manuel Eduardo Hernández-García , Jorge Velázquez-Castro

Investigation of protein self-assembly processes is important for the understanding of the growth processes of functional proteins as well as disease-causing amyloids. Inside cells, intrinsic molecular fluctuations are so high that they…

Biological Physics · Physics 2021-02-03 John Bridstrup , John S Schreck , Jesse L Jorgenson , Jian-Min Yuan

Simplified stochastic models are widely used in the study of frequency-resolved noise propagation in biochemical reaction networks, a common measure being the coherence between random fluctuations in molecule number trajectories. Such…

Molecular Networks · Quantitative Biology 2025-11-03 Juan David Marmolejo Lozano , Nikola Popovic , Ramon Grima

We study the dynamics of fronts when both inertial effects and external fluctuations are taken into account. Stochastic fluctuations are introduced as multiplicative noise arising from a control parameter of the system. Contrary to the…

Statistical Mechanics · Physics 2009-10-31 Jose M. Sancho , Angel Sanchez

Noise in gene expression, either due to inherent stochasticity or to varying inter- and intracellular environment, can generate significant cell-to-cell variability of protein levels in clonal populations. We present a theoretical…

Other Quantitative Biology · Quantitative Biology 2010-04-08 Julia Rausenberger , Christian Fleck , Jens Timmer , Markus Kollmann

Causal ordering of key events in the cell cycle is essential for proper functioning of an organism. Yet, it remains a mystery how a specific temporal program of events is maintained despite ineluctable stochasticity in the biochemical…

Molecular Networks · Quantitative Biology 2017-03-30 Farshid Jafarpour , Michael Vennettilli , Srividya Iyer-Biswas

Here we report on the viscosity of eukaryotic living cells as a function of the time, and on the application of stochastic models to analyze its temporal fluctuations. The viscoelastic properties of NIH/3T3 fibroblastic cells are…

Soft Condensed Matter · Physics 2021-09-21 Claude L. Bostoen , Jean-François Berret

Biological processes at the cellular level are stochastic in nature, and the immune response system is no different. Therefore, models that attempt to explain this system need to also incorporate noise or fluctuations that can account for…

Molecular Networks · Quantitative Biology 2021-06-16 Abhilasha Batra , Rati Sharma

Cortical sensory neurons are known to be highly variable, in the sense that responses evoked by identical stimuli often change dramatically from trial to trial. The origin of this variability is uncertain, but it is usually interpreted as…

Neurons and Cognition · Quantitative Biology 2007-05-23 Gleb Basalyga , Emilio Salinas

Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is skeleton model…

Molecular Networks · Quantitative Biology 2018-09-06 Raoul R. Wadhwa , Laszlo Zalanyi , Judit Szente , Laszlo Negyessy , Peter Erdi

The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule…

Biological Physics · Physics 2014-06-12 Jay Newby

Synthetic biology is a growing interdisciplinary field, with far-reaching applications, which aims to design biochemical systems that behave in a desired manner. With the advancement of strand-displacement DNA computing, a large class of…

Molecular Networks · Quantitative Biology 2017-06-21 Tomislav Plesa , Konstantinos C. Zygalakis , David F. Anderson , Radek Erban

We address microscopic, agent based, and macroscopic, stochastic, modeling of the financial markets combining it with the exogenous noise. The interplay between the endogenous dynamics of agents and the exogenous noise is the primary…

Statistical Finance · Quantitative Finance 2016-11-22 Vygintas Gontis

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

Molecular Networks · Quantitative Biology 2022-12-29 Niklas Bonacker , Johannes Berg