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Many studies have shown that the excitation and inhibition received by cortical neurons remain roughly balanced across many conditions. A key question for understanding the dynamical regime of cortex is the nature of this balancing.…

Neurons and Cognition · Quantitative Biology 2019-08-29 Yashar Ahmadian , Kenneth D. Miller

In recent years, there have been many computational simulations of spontaneous neural dynamics. Here, we explore a model of spontaneous neural dynamics and allow it to control a virtual agent moving in a simple environment. This setup…

Neurons and Cognition · Quantitative Biology 2016-08-19 Peter J. Hellyer , Claudia Clopath , Angie A. Kehagia , Federico E. Turkheimer , Robert Leech

It is widely appreciated that well-balanced excitation and inhibition are necessary for proper function in neural networks. However, in principle, such balance could be achieved by many possible configurations of excitatory and inhibitory…

Neurons and Cognition · Quantitative Biology 2018-11-14 Vidit Agrawal , Andrew B. Cowley , Qusay Alfaori , Juan G. Restrepo , Daniel B. Larremore , Woodrow L. Shew

We examine the dynamical evolution of the state of a neurone, with particular care to the non-equilibrium nature of the forces influencing its movement in state space. We combine non-equilibrium statistical mechanics and dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-02-19 Dalton A R Sakthivadivel

Large networks of spiking neurons show abrupt changes in their collective dynamics resembling phase transitions studied in statistical physics. An example of this phenomenon is the transition from irregular, noise-driven dynamics to…

Adaptation and Self-Organizing Systems · Physics 2008-11-25 Vicenç Gómez , Andreas Kaltenbrunner , Vicente López , Hilbert J. Kappen

We study the stability of the dynamics of a network of n neurons intercting linearly through a random gaussian matrix of excitatory and inhibitory type. Using the aproach developed in a previous paper we show some interesting properties of…

Mathematical Physics · Physics 2011-11-10 J. F. Feng , M. Shcherbina , B. Tirozzi

Theoretical models of neuronal function consider different mechanisms through which networks learn, classify and discern inputs. A central focus of these models is to understand how associations are established amongst neurons, in order to…

Neurons and Cognition · Quantitative Biology 2015-05-19 Harold P. de Vladar , Eörs Szathmáry

While the support for the relevance of critical dynamics to brain function is increasing, there is much less agreement on the exact nature of the advocated critical point. Thus, a considerable number of theoretical efforts are currently…

Disordered Systems and Neural Networks · Physics 2024-01-01 Joaquin Almeira , Tomas S. Grigera , Dante R. Chialvo , Sergio A. Cannas

Large sparse circuits of spiking neurons exhibit a balanced state of highly irregular activity under a wide range of conditions. It occurs likewise in sparsely connected random networks that receive excitatory external inputs and recurrent…

Neurons and Cognition · Quantitative Biology 2013-08-16 Sven Jahnke , Raoul-Martin Memmesheimer , Marc Timme

Biological neural networks self-organize according to local synaptic modifications to produce stable computations. How modifications at the synaptic level give rise to such computations at the network level remains an open question.…

Neurons and Cognition · Quantitative Biology 2026-01-21 David Lipshutz , Robert J. Lipshutz

Previous work showed that the collective activity of large neuronal networks can be tamed to remain near its critical point by a feedback control that maximizes the temporal correlations of the mean-field fluctuations. Since such…

Neurons and Cognition · Quantitative Biology 2023-03-29 Juliane T. Moraes , Eyisto J. Aguilar Trejo , Sabrina Camargo , Silvio C. Ferreira , Dante R. Chialvo

Inhibitory neurons play a crucial role in maintaining persistent neuronal activity. Although connected extensively through electrical synapses (gap-junctions), these neurons also exhibit interactions through chemical synapses in certain…

Neurons and Cognition · Quantitative Biology 2021-04-08 R. Janaki , A. S. Vytheeswaran

Criticality can be exactly demonstrated in certain models of brain activity, yet it remains challenging to identify in empirical data. We trained a fully connected deep neural network to learn the phases of an excitable model unfolding on…

Neurons and Cognition · Quantitative Biology 2022-06-13 Hernan Bocaccio , Enzo Tagliazucchi

The brain is in a state of perpetual reverberant neural activity, even in the absence of specific tasks or stimuli. Shedding light on the origin and functional significance of such a dynamical state is essential to understanding how the…

Statistical Mechanics · Physics 2022-07-08 Guillermo B. Morales , Serena Di Santo , Miguel A. Munoz

When inhibitory neurons constitute about 40% of neurons they could have an important antinociceptive role, as they would easily regulate the level of activity of other neurons. We consider a simple network of cortical spiking neurons with…

Neurons and Cognition · Quantitative Biology 2014-01-28 Fernando Montani , Emilia B. Deleglise , Osvaldo A. Rosso

Recent experimental results based on multi-electrode and imaging techniques have reinvigorated the idea that large neural networks operate near a critical point, between order and disorder. However, evidence for criticality has relied on…

Neurons and Cognition · Quantitative Biology 2015-03-05 Thierry Mora , Stéphane Deny , Olivier Marre

This paper is concerned with the modeling and analysis of two of the most commonly used recurrent neural network models (i.e., Hopfield neural network and firing-rate neural network) with dynamic recurrent connections undergoing Hebbian…

Optimization and Control · Mathematics 2024-03-25 Veronica Centorrino , Francesco Bullo , Giovanni Russo

Cortical activity in-vivo displays relaxational time scales much longer than the membrane time constant of the neurons or the deactivation time of ionotropic synaptic conductances. The mechanisms responsible for such slow dynamics are not…

Disordered Systems and Neural Networks · Physics 2025-08-07 Ferdinand Tixidre , Gianluigi Mongillo , Alessandro Torcini

The state space of a conventional Hopfield network typically exhibits many different attractors of which only a small subset satisfy constraints between neurons in a globally optimal fashion. It has recently been demonstrated that combining…

Adaptation and Self-Organizing Systems · Physics 2014-09-02 Alexander Woodward , Tom Froese , Takashi Ikegami

Neural circuits are able to perform computations under very diverse conditions and requirements. The required computations impose clear constraints on their fine-tuning: a rapid and maximally informative response to stimuli in general…

Neurons and Cognition · Quantitative Biology 2019-10-22 Jens Wilting , Jonas Dehning , Joao Pinheiro Neto , Lucas Rudelt , Michael Wibral , Johannes Zierenberg , Viola Priesemann