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Mechanistic network models specify the mechanisms by which networks grow and change, allowing researchers to investigate complex systems using both simulation and analytical techniques. Unfortunately, it is difficult to write likelihoods…

Methodology · Statistics 2023-07-19 Jonathan Larson , Jukka-Pekka Onnela

The so-called binary perfect phylogeny with persistent characters has recently been thoroughly studied in computational biology as it is less restrictive than the well known binary perfect phylogeny. Here, we focus on the notion of (binary)…

Populations and Evolution · Quantitative Biology 2020-03-30 Kristina Wicke , Mareike Fischer

In phylogenetics, distances are often used to measure the incongruence between a pair of phylogenetic trees that are reconstructed by different methods or using different regions of genome. Motivated by the maximum parsimony principle in…

Populations and Evolution · Quantitative Biology 2016-07-08 Steven Kelk , Mareike Fischer , Vincent Moulton , Taoyang Wu

Likelihood-based methods are widely considered the best approaches for reconstructing ancestral states. Although much effort has been made to study properties of these methods, previous works often assume that both the tree topology and…

Methodology · Statistics 2021-04-02 Lam Si Tung Ho , Edward Susko

Motivation: Word-based or `alignment-free' methods for phylogeny reconstruction are much faster than traditional approaches, but they are generally less accurate. Most of these methods calculate pairwise distances for a set of input…

Populations and Evolution · Quantitative Biology 2018-05-01 Thomas Dencker , Chris-Andre Leimeister , Michael Gerth , Christoph Bleidorn , Sagi Snir , Burkhard Morgenstern

Works, briefly surveyed here, are concerned with two basic methods: Maximum Probability and Bayesian Maximum Probability; as well as with their asymptotic instances: Relative Entropy Maximization and Maximum Non-parametric Likelihood.…

Statistics Theory · Mathematics 2008-04-25 M. Grendar

We answer two questions raised by Bryant, Francis and Steel in their work on consensus methods in phylogenetics. Consensus methods apply to every practical instance where it is desired to aggregate a set of given phylogenetic trees (say,…

Populations and Evolution · Quantitative Biology 2023-11-14 Emanuele Delucchi , Linard Hoessly , Giovanni Paolini

When estimating a phylogeny from a multiple sequence alignment, researchers often assume the absence of recombination. However, if recombination is present, then tree estimation and all downstream analyses will be impacted, because…

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees. Substitutions in sequences are modelled through a continuous-time Markov process, characterised by an instantaneous rate matrix, which standard…

Populations and Evolution · Quantitative Biology 2020-07-20 Naomi E. Hannaford , Sarah E. Heaps , Tom M. W. Nye , Tom A. Williams , T. Martin Embley

Phylogeny can be inferred using two sources of data from an organism: morphological data and molecular data. Historically, phylogenies were usually inferred using morphological characters, but some morphological features may not necessarily…

Populations and Evolution · Quantitative Biology 2023-12-19 Ray Han

The reliability of a phylogenetic inference method from genomic sequence data is ensured by its statistical consistency. Bayesian inference methods produce a sample of phylogenetic trees from the posterior distribution given sequence data.…

Metric Geometry · Mathematics 2016-06-10 Alex Gavryushkin , Alexei J. Drummond

Bayesian inference is now a leading technique for reconstructing phylogenetic trees from aligned sequence data. In this short note, we formally show that the maximum posterior tree topology provides a statistically consistent estimate of a…

Populations and Evolution · Quantitative Biology 2013-07-12 Mike Steel

This paper compares the Maximum-likelihood method and Bayesian method for finite element model updating. The Maximum-likelihood method was implemented using genetic algorithm while the Bayesian method was implemented using the Markov Chain…

Applications · Statistics 2007-05-23 Tshilidzi Marwala , Lungile Mdlazi , Sibusiso Sibisi

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

Populations and Evolution · Quantitative Biology 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

In evolutionary biology, genetic sequences carry with them a trace of the underlying tree that describes their evolution from a common ancestral sequence. The question of how many sequence sites are required to recover this evolutionary…

Populations and Evolution · Quantitative Biology 2008-06-17 Mareike Fischer , Mike Steel

We study maximal clades in random phylogenetic trees with the Yule-Harding model or, equivalently, in binary search trees. We use probabilistic methods to reprove and extend earlier results on moment asymptotics and asymptotic normality. In…

Probability · Mathematics 2014-08-28 Svante Janson

Phylogenetic trees are simple models of evolutionary processes. They describe conditionally independent divergent evolution of taxa from common ancestors. Phylogenetic trees commonly do not have enough flexibility to adequately model all…

Populations and Evolution · Quantitative Biology 2025-11-11 Jonathan D. Mitchell , Barbara R. Holland

Fixed tree topologies are widely used in phylodynamic analyses to reduce computational burden, yet the consequences of this assumption remain insufficiently understood. Here, we systematically assess the impact of various fixed-topology…

Populations and Evolution · Quantitative Biology 2025-12-01 Mathieu Fourment , Jiansi Gao , Marc A Suchard , Frederick A Matsen

The (non-)equivalence of canonical and microcanonical ensembles is a fundamental question in statistical physics, concerning whether the use of soft and hard constraints in the maximum-entropy construction leads to the same description of a…

Statistical Mechanics · Physics 2025-11-25 Francesca Giuffrida , Tiziano Squartini , Peter Grünwald , Diego Garlaschelli

Given a graph in which a few vertices are deemed interesting a priori, the vertex nomination task is to order the remaining vertices into a nomination list such that there is a concentration of interesting vertices at the top of the list.…

Machine Learning · Statistics 2016-08-30 Vince Lyzinski , Keith Levin , Donniell E. Fishkind , Carey E. Priebe