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To study information processing in the brain, neuroscientists manipulate experimental stimuli while recording participant brain activity. They can then use encoding models to find out which brain "zone" (e.g. which region of interest,…

Neurons and Cognition · Quantitative Biology 2022-02-22 Mariya Toneva , Jennifer Williams , Anand Bollu , Christoph Dann , Leila Wehbe

Understanding the activity of large populations of neurons is difficult due to the combinatorial complexity of possible cell-cell interactions. To reduce the complexity, coarse-graining had been previously applied to experimental neural…

Neurons and Cognition · Quantitative Biology 2021-03-24 Mia C. Morrell , Audrey J. Sederberg , Ilya Nemenman

Symbolic techniques based on Satisfiability Modulo Theory (SMT) solvers have been proposed for analyzing and verifying neural network properties, but their usage has been fairly limited owing to their poor scalability with larger networks.…

Machine Learning · Computer Science 2021-05-06 Subham Sekhar Sahoo , Subhashini Venugopalan , Li Li , Rishabh Singh , Patrick Riley

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

This thesis is dedicated to the statistical analysis of multi-sub ject fMRI data, with the purpose of identifying bain structures involved in certain cognitive or sensori-motor tasks, in a reproducible way across sub jects. To overcome…

Applications · Statistics 2010-05-19 Merlin Keller , Alexis Roche , Marc Lavielle

The participation of astrocytes in brain computation was formally hypothesized in 1992, coinciding with the discovery that these glial cells display a complex form of Ca2+ excitability. This fostered conceptual advances centered on the…

Neurons and Cognition · Quantitative Biology 2023-10-23 Ciaran Murphy-Royal , ShiNung Ching , Thomas Papouin

Intracranial recordings have opened a unique opportunity to simultaneously measure activity across multiregional networks in the human brain. Recent works have focused on developing transformer-based neurofoundation models of such…

Machine Learning · Computer Science 2025-12-16 Lucine L. Oganesian , Saba Hashemi , Maryam M. Shanechi

The neural networks of the brain are capable of learning statistical input regularities on the basis of synaptic learning, functional integration into increasingly larger, interconnected neural assemblies, and self organization. This self…

Robotics · Computer Science 2022-06-10 Birgitta Dresp-Langley

The brain's structural connectome supports signal propagation between neuronal elements, shaping diverse coactivation patterns that can be captured as functional connectivity. While the link between structure and function remains an ongoing…

Neurons and Cognition · Quantitative Biology 2022-07-11 Yaqian Yang , Zhiming Zheng , Longzhao Liu , Hongwei Zheng , Yi Zhen , Yi Zheng , Xin Wang , Shaoting Tang

How does the human brain encode complex visual information? While previous research has characterized individual dimensions of visual representation in cortex, we still lack a comprehensive understanding of how visual information is…

Neurons and Cognition · Quantitative Biology 2026-04-08 Raj Magesh Gauthaman , Brice Ménard , Michael F. Bonner

Learning requires the traversal of inherently distinct cognitive states to produce behavioral adaptation. Yet, tools to explicitly measure these states with non-invasive imaging -- and to assess their dynamics during learning -- remain…

Purpose: Recently, there has been a revived interest in system neuroscience causation models, driven by their unique capability to unravel complex relationships in multi-scale brain networks. In this paper, we present a novel method that…

Systems and Control · Electrical Eng. & Systems 2025-10-03 Dachuan Song , Li Shen , Duy Duong-Tran , Xuan Wang

Deep learning is leading to major advances in the realm of brain decoding from functional Magnetic Resonance Imaging (fMRI). However, the large inter-subject variability in brain characteristics has limited most studies to train models on…

Machine Learning · Computer Science 2023-12-12 Alexis Thual , Yohann Benchetrit , Felix Geilert , Jérémy Rapin , Iurii Makarov , Hubert Banville , Jean-Rémi King

Identifying the brain's neuronal cluster size to be presented as nodes in a network computation is critical to both neuroscience and artificial intelligence, as these define the cognitive blocks required for building intelligent…

Neurons and Cognition · Quantitative Biology 2020-02-26 Anar Amgalan , Patrick Taylor , Lilianne R. Mujica-Parodi , Hava T. Siegelmann

Despite the fact that only a small portion of muscles are affected in motion disease and disorders, medical therapies do not distinguish between healthy and unhealthy muscles. In this paper, a method is devised in order to calculate the…

Artificial Intelligence · Computer Science 2024-03-06 Sina Saadati , Mohammadreza Razzazi

Functional differentiation in the brain emerges as distinct regions specialize and is key to understanding brain function as a complex system. Previous research has modeled this process using artificial neural networks with specific…

Neurons and Cognition · Quantitative Biology 2025-11-17 Yuki Tomoda , Ichiro Tsuda , Yutaka Yamaguti

Thanks to novel, powerful brain activity recording techniques, we can create data-driven models from thousands of recording channels and large portions of the cortex, which can improve our understanding of brain-states neuromodulation and…

Current theoretical and computational models of dopamine-based reinforcement learning are largely rooted in the classical behaviorist tradition, and envision the organism as a purely reactive recipient of rewards and punishments, with…

Neurons and Cognition · Quantitative Biology 2014-05-01 Randall C. O'Reilly , Thomas E. Hazy , Jessica Mollick , Prescott Mackie , Seth Herd

Neurons in cortical circuits exhibit coordinated spiking activity, and can produce correlated synchronous spikes during behavior and cognition. We recently developed a method for estimating the dynamics of correlated ensemble activity by…

Neurons and Cognition · Quantitative Biology 2013-12-17 Hideaki Shimazaki

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…