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We propose a new statistical approach to obtain differential gene expression of non-detects in quantitative real-time PCR (qPCR) experiments through Bayesian hierarchical modeling. We propose to treat non-detects as non-random missing data,…

Applications · Statistics 2019-10-31 Valeriia Sherina , Matthew N. McCall , Tanzy M. T. Love

Empirical analysis serves as an important complement to theoretical analysis for studying practical Bayesian optimization. Often empirical insights expose strengths and weaknesses inaccessible to theoretical analysis. We define two metrics…

Machine Learning · Computer Science 2016-04-01 Ian Dewancker , Michael McCourt , Scott Clark , Patrick Hayes , Alexandra Johnson , George Ke

Bayesian probabilistic numerical methods are a set of tools providing posterior distributions on the output of numerical methods. The use of these methods is usually motivated by the fact that they can represent our uncertainty due to…

Computation · Statistics 2018-08-01 Xiaoyue Xi , François-Xavier Briol , Mark Girolami

The problem of large scale multiple testing arises in many contexts, including testing for pairwise interaction among large numbers of neurons. With advances in technologies, it has become common to record from hundreds of neurons…

Computation · Statistics 2017-11-02 Bin Liu , Giuseppe Vinci , Adam C. Snyder , Robert E. Kass

Variable selection has played a critical role in modern statistical learning and scientific discoveries. Numerous regularization and Bayesian variable selection methods have been developed in the past two decades for variable selection, but…

Methodology · Statistics 2024-03-04 Travis Canida , Hongjie Ke , Shuo Chen , Zhenayo Ye , Tianzhou Ma

We present a novel Bayesian nonparametric regression model for covariates X and continuous, real response variable Y. The model is parametrized in terms of marginal distributions for Y and X and a regression function which tunes the…

Methodology · Statistics 2015-06-25 Tristan Gray-Davies , Chris Holmes , Francois Caron

Given the joint chances of a pair of random variables one can compute quantities of interest, like the mutual information. The Bayesian treatment of unknown chances involves computing, from a second order prior distribution and the data…

Machine Learning · Computer Science 2007-05-23 Marcus Hutter , Marco Zaffalon

In this paper, in order to test whether changes have occurred in a nonlinear parametric regression, we propose a nonparametric method based on the empirical likelihood. Firstly, we test the null hypothesis of no-change against the…

Statistics Theory · Mathematics 2014-05-22 Gabriela Ciuperca , Zahraa Salloum

The multiple testing literature has primarily dealt with three types of dependence assumptions between p-values: independence, positive regression dependence, and arbitrary dependence. In this paper, we provide what we believe are the first…

Statistics Theory · Mathematics 2024-05-10 Ziyu Chi , Aaditya Ramdas , Ruodu Wang

Inference after model selection has been an active research topic in the past few years, with numerous works offering different approaches to addressing the perils of the reuse of data. In particular, major progress has been made recently…

Methodology · Statistics 2020-06-02 Snigdha Panigrahi , Jonathan Taylor , Asaf Weinstein

Likelihood-free methods, such as approximate Bayesian computation, are powerful tools for practical inference problems with intractable likelihood functions. Markov chain Monte Carlo and sequential Monte Carlo variants of approximate…

Computation · Statistics 2019-02-26 David J. Warne , Ruth E. Baker , Matthew J. Simpson

Accurate and precise covariance matrices will be important in enabling planned cosmological surveys to detect new physics. Standard methods imply either the need for many N-body simulations in order to obtain an accurate estimate, or a…

Cosmology and Nongalactic Astrophysics · Physics 2018-12-13 Alex Hall , Andy Taylor

Bayesian analysis is increasingly popular for use in social science and other application areas where the data are observations from an informative sample. An informative sampling design leads to inclusion probabilities that are correlated…

Statistics Theory · Mathematics 2016-06-07 Terrance D. Savitsky , Daniell Toth

Empirical likelihood approach is one of non-parametric statistical methods, which is applied to the hypothesis testing or construction of confidence regions for pivotal unknown quantities. This method has been applied to the case of…

Statistics Theory · Mathematics 2015-09-21 Fumiya Akashi , Yan Liu , Masanobu Taniguchi

Prior probabilities of clinical hypotheses are not systematically used for clinical trial design yet, due to a concern that poor priors may lead to poor decisions. To address this concern, a conservative approach to Bayesian trial design is…

Methodology · Statistics 2023-09-21 Fabio Rigat

How to sample high quality negative instances from unlabeled data, i.e., negative sampling, is important for training implicit collaborative filtering and contrastive learning models. Although previous studies have proposed some approaches…

Information Retrieval · Computer Science 2022-07-12 Bin Liu , Bang Wang

In this paper we are interested in empirical likelihood (EL) as a method of estimation, and we address the following two problems: (1) selecting among various empirical discrepancies in an EL framework and (2) demonstrating that EL has a…

Statistics Theory · Mathematics 2009-08-25 Marian Grendár , George Judge

In this paper we revisit the weighted likelihood bootstrap, a method that generates samples from an approximate Bayesian posterior of a parametric model. We show that the same method can be derived, without approximation, under a Bayesian…

Methodology · Statistics 2018-05-23 Simon Lyddon , Chris Holmes , Stephen Walker

Empirical likelihood enables a nonparametric, likelihood-driven style of inference without restrictive assumptions routinely made in parametric models. We develop a framework for applying empirical likelihood to the analysis of experimental…

Methodology · Statistics 2023-11-08 Eunseop Kim , Steven N. MacEachern , Mario Peruggia

Policy decisions often depend on evidence generated elsewhere. We take a Bayesian decision-theoretic approach to choosing where to experiment to optimize external validity. We frame external validity through a policy lens, developing a…

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