Related papers: Rapid divergence of the ecdysone receptor in Dipte…
Efficient convolutional neural network (CNN) architecture design has attracted growing research interests. However, they typically apply single receptive field (RF), small asymmetric RFs, or pyramid RFs to learn different feature…
The recent literature suggests that an evolutionary dichotomy exists for early-type galaxies (Es and S0s, ETGs) whereby their central photometric structure (cuspy versus core central luminosity profiles), and figure of rotation (fast (FR)…
Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional…
The evolutionary trajectory of a protein through sequence space is constrained by function and three-dimensional (3D) structure. Residues in spatial proximity tend to co-evolve, yet attempts to invert the evolutionary record to identify…
Differences in the regional substitution patterns in the human genome created patterns of large-scale variation of base composition known as genomic isochores. To gain insight into the origin of the genomic isochores we develop a maximum…
The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks…
As pathogens spread in a population of hosts, immunity is built up and the pool of susceptible individuals is depleted. This generates selective pressure, to which many human RNA viruses, such as influenza virus or SARS-CoV-2, respond with…
Recently, convolutional networks have achieved remarkable development in remote sensing image Super-Resoltuion (SR) by minimizing the regression objectives, e.g., MSE loss. However, despite achieving impressive performance, these methods…
The Hertzsprung-Russell diagram is an essential diagnostic diagram for stellar structure and evolution, which has now been in use for more than 100 years. Our spectroscopic Hertzsprung-Russell (sHR) diagram shows the inverse of the…
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly…
While confirming the long held view that viruses do not closely imitate the use of their host's codon catalogue, Esposito and coworkers nevertheless consider it surprising that, despite having the ability to infect the same host, many…
A long-standing goal of evolutionary biology is to decode how gene regulatory processes contribute to organismal diversity, both within and between species. This question has remained challenging to answer, due both to the difficulties of…
Motivation: Genome rearrangement plays an important role in evolutionary biology and has profound impacts on phenotype in organisms ranging from microbes to humans. The mechanisms for genome rearrangement events remain unclear. Lots of…
Statistical analysis of protein-protein interactions shows anomalously high frequency of homodimers [Ispolatov, I., et al. (2005) Nucleic Acids Res 33, 3629-35]. Furthermore, recent findings [Wright, C.F., et al. (2005) Nature 438, 878-81]…
Molecular interactions are key to many chemical and biological processes like protein function. In many signaling processes they occur in sub-cellular areas displaying nanoscale organizations and involving molecular assemblies. The…
Photodisintegration is a main energy loss process for ultrahigh-energy cosmic-ray (UHECR) nuclei in intergalactic space. Therefore, it is crucial to understand systematic uncertainty in photodisintegration when simulating the propagation of…
The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of tubes and sheets, is an important location of protein synthesis and folding. When the ER experiences sustained unfolded protein stress, IRE1 proteins…
It is the goal of systems biology to understand the behavior of the whole in terms of the knowledge of the parts. This is hard to achieve in many cases due to the difficulty of characterizing the many constituents and their complex web of…
Convolutional neural network (CNN) based methods have recently achieved great success for image super-resolution (SR). However, most deep CNN based SR models attempt to improve distortion measures (e.g. PSNR, SSIM, IFC, VIF) while resulting…
Heterogeneous computing integrates diverse processing elements, such as CPUs, GPUs, and FPGAs, within a single system, aiming to leverage the strengths of each architecture to optimize performance and energy consumption. In this context,…