Related papers: The C-value enigma and timing of the Cambrian expl…
Why (and how) the Universe was born is one of the ultimate questions in physics. Another big puzzle is about the arrow of time: why is there only one direction of time? Are these two issues related? One way to solve both puzzles at one…
The evolution of complexity has been a central theme for Biology [2] and Artificial Life research [1]. It is generally agreed that complexity has increased in our universe, giving way to life, multi-cellularity, societies, and systems of…
A model of genome evolution is proposed. Based on three assumptions the evolutionary theory of a genome is formulated. The general law on the direction of genome evolution is given. Both the deterministic classical equation and the…
Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia prowazekii) of most animal genomes is non-coding DNA. Although recent studies established functions of its certain portions, it remains genomic dark matter. The paper…
The origin of the Chicxulub impactor, which is attributed as the cause of the K/T mass extinction event, is an unsolved puzzle. The background impact rates of main-belt asteroids and long-period comets have been previously dismissed as…
Most supernova explosions accompany the death of a massive star. These explosions give birth to neutron stars and black holes and eject solar masses of heavy elements. However, determining the mechanism of explosion has been a half-century…
Eukaryote genomes contain excessively introns, inter-genic and other non-genic sequences that appear to have no vital functional role or phenotype manifestation. Their existence, a long-standing puzzle, is viewed from the principle of…
The Earth's climate has experienced numerous critical transitions during its history, which have often been accompanied by massive and rapid changes in the biosphere. Such transitions are evidenced in various proxy records covering…
The prevalence of sexual reproduction ("sex") in eukaryotes is an enigma of evolutionary biology. Sex increases genetic variation only tells its long-term superiority in essence. The accumulation of harmful mutations causes an immediate and…
We review why the search for a causal explanation of the large scale properties of the universe supports the idea that an extended period of accelerated expansion, called inflation, preceded primordial nucleosynthesis. As a consequence of…
The discovery and genome analysis of Acanthamoeba polyphaga Mimivirus, the largest known DNA virus, challenged much of the accepted dogma regarding viruses. Its particle size (>400 nm), genome length (1.2 million bp) and huge gene…
Despite numerous mass extinctions in the Phanerozoic eon, the overall trend in biodiversity evolution was not blocked and the life has never been wiped out. Almost all possible catastrophic events (large igneous province, asteroid impact,…
The existence of complex (multiple-step) genetic adaptations that are "irreducible" (i.e., all partial combinations are less fit than the original genotype) is one of the longest standing problems in evolutionary biology. In standard…
In this article, I put forward the idea that the neoplastic process (NP) has deep evolutionary roots and make specific predictions about the connection between cancer and the formation of the first embryo, which allowed for the evolutionary…
Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…
The genetic code is nearly universal, and the arrangement of the codons in the standard codon table is highly non-random. The three main concepts on origin and evolution of the code are the stereochemical theory; the coevolution theory; and…
The origin of life on Earth via the spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question in physics and chemistry. Here, we develop a conceptual framework based on information theory and…
The supernova explosion of 1054 AD, which originated the Crab Nebula and Pulsar, is probably the astronomical event which has been most deeply studied by means of historical sources. However, many mysteries and inconsistencies, both among…
Quantum complexity is conjectured to probe inside of black hole horizons (or wormhole) via gauge gravity correspondence. In order to have a better understanding of this correspondence, we study time evolutions of complexities for generic…
The emergence of a predominant phenotype within a cell population is often triggered by a rare accumulation of DNA mutations in a single cell. For example, tumors may be initiated by a single cell in which multiple mutations cooperate to…