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Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…
The neural networks of the human brain act as very efficient parallel processing computers co-ordinating memory related responses to a multitude of input signals from sensory organs. Information storage, update and appropriate retrieval are…
This paper introduces a biomathematical model designed to describe the internal dynamics of dream formation and spontaneous cognitive processes. The model incorporates neurocognitive factors such as dissatisfaction, acceptance, forgetting,…
Neural activity fluctuates over a wide range of timescales within and across brain areas. Experimental observations suggest that diverse neural timescales reflect information in dynamic environments. However, how timescales are defined and…
The brain works as a dynamic system to process information. Various challenges remain in understanding the connection between information and dynamics attributes in the brain. The present research pursues exploring how the characteristics…
Neural activity patterns related to behavior occur at many scales in time and space from the atomic and molecular to the whole brain. Here we explore the feasibility of interpreting neurophysiological data in the context of many-body…
The human brain is composed of distinct regions that are each associated with particular functions and distinct propensities for the control of neural dynamics. However, the relation between these functions and control profiles is poorly…
The cognitive functions of human and non-human primates rely on the dynamic interplay of distributed neural assemblies. As such, it seems unlikely that cognition can be supported by macroscopic brain dynamics at the proximity of…
This PhD thesis is focused on the central idea that single neurons in the brain should be regarded as temporally precise and highly complex spatio-temporal pattern recognizers. This is opposed to the prevalent view of biological neurons as…
The distinct timescales of synaptic plasticity and neural activity dynamics play an important role in the brain's learning and memory systems. Activity-dependent plasticity reshapes neural circuit architecture, determining spontaneous and…
This report is concerned with the relevance of the microscopic rules, that implement individual neuronal activation, in determining the collective dynamics, under variations of the network topology. To fix ideas we study the dynamics of two…
Recordings of whole brain activity with single neuron resolution are now feasible in simple organisms. Yet, it is still challenging to appropriately simplify such complex, noisy, and multivariate data in order to reveal general principles…
A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…
Neural mass models describe the mean-field dynamics of populations of neurons. In this work we illustrate how fundamental ideas of physics, such as energy and conserved quantities, can be explored for such models. We show that…
Molecular dynamics simulations use statistical mechanics at the atomistic scale to enable both the elucidation of fundamental mechanisms and the engineering of matter for desired tasks. The behavior of molecular systems at the microscale is…
In recent years, there have been many computational simulations of spontaneous neural dynamics. Here, we explore a model of spontaneous neural dynamics and allow it to control a virtual agent moving in a simple environment. This setup…
This manuscript aims to illustrate a quantum-classical dissipative theory (suited to be converted to effective algorithms for numerical simulations) within the long-term project of studying molecular processes in the brain. Other…
Evidence of critical dynamics has been recently found in both experiments and models of large scale brain dynamics. The understanding of the nature and features of such critical regime is hampered by the relatively small size of the…
Starting from the concept of binary interactions between pairs of particles, a kinetic framework for the description of the action potential dynamics on a neural network is proposed. It consists of two coupled levels: the description of a…
This paper describes the outlines of a research program for understanding the cognitive-emotional brain, with an emphasis on the issue of dynamics: How can we study, characterize, and understand the neural underpinnings of…