Related papers: Single-molecule force spectroscopy: Practical limi…
Long-range forces between macroscopic objects are mediated by light particles that interact with the electrons or nucleons, and include spin-dependent static components as well as spin- and velocity-dependent components. We parametrize the…
The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters e.g the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon…
In single-molecule force spectroscopy experiments, a biomolecule is attached to a force probe via polymer linkers, and the total extension -- of molecule plus apparatus -- is monitored as a function of time. In a typical unfolding…
We consider reversible breaking of adhesion bonds or folding of proteins under the influence of a constant external force. We discuss the stochastic properties of the unbinding/rebinding events and analyze their mean number and their…
I review single-molecule experiments (SME) in biological physics. Recent technological developments have provided the tools to design and build scientific instruments of high enough sensitivity and precision to manipulate and visualize…
We propose a new model and estimation framework for spatiotemporal streamflow exceedances above a threshold that flexibly captures asymptotic dependence and independence in the tail of the distribution. We model streamflow using a mixture…
How long a stochastic process survives before leaving a domain depends not only on its intrinsic dynamics but also on how it is observed. Classical first-passage theory assumes continuous monitoring with absorbing boundaries…
The mechanical properties of PC12 living cells have been studied at the nanoscale with a Force Feedback Microscope using two experimental approaches. Firstly, the local mechanical impedance of the cell membrane has been mapped…
Stochastic computational models in the form of pure jump processes occur frequently in the description of chemical reactive processes, of ion channel dynamics, and of the spread of infections in populations. For spatially extended models,…
Reliability theory is used to assess the sensitivity of a passive flexion and active flexion of the human lower leg Finite Element (FE) models with Total Knee Replacement (TKR) to the variability in the input parameters of the respective FE…
Brownian escape is key to a wealth of physico-chemical processes, including polymer folding, and information storage. The frequency of thermally activated energy barrier crossings is assumed to generally decrease exponentially with…
We analyze the force-extension curve for a general class of systems, which are described at the mesoscopic level by a free energy depending on the extension of its components. Similarly to what is done in real experiments, the total length…
This paper investigates the identifiability and estimation of the parameters of the single particle model (SPM) for lithium-ion battery simulation. Identifiability is addressed both in principle and in practice. The approach begins by…
Panic-induced herding in individuals often leads to social disasters, resulting in people being trapped and trampled in crowd stampedes triggered by panic. We introduce a novel approach that offers fresh insights into studying the…
The spectroscopic factor has long played a central role in nuclear reaction theory. However, it is not an observable. Consequently it is of minimal use as a meeting point between theory and experiment. In this paper the nature of the…
Extensive research in pedestrian dynamics has primarily focused on crowded conditions and associated phenomena, such as lane formation, evacuation, etc. Several force-based models have been developed to predict the behavior in these…
This paper addresses learning safe output feedback control laws from partial observations of expert demonstrations. We assume that a model of the system dynamics and a state estimator are available along with corresponding error bounds,…
Heterogeneity in biological molecules, resulting in molecule-to-molecule variations in their dynamics and function, is an emerging theme. To elucidate the consequences of heterogeneous behavior at the single molecule level, we propose an…
Atmosphere-breathing electric propulsion systems harness atmospheric particles as propellant, enabling efficient operation across diverse environmental conditions. To accurately simulate the captured gas flow through the modules,…
The Fermi effective theory of the weak interaction helped identify the structure of the electroweak sector of the Standard Model, and the chiral effective Lagrangian pointed towards QCD as the theory of the strong interactions. The Standard…