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A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like. Pathways of ambiguity reduction enlarged the codon…

Populations and Evolution · Quantitative Biology 2007-11-06 Peter van der Gulik

Manifold learning methods are an invaluable tool in today's world of increasingly huge datasets. Manifold learning algorithms can discover a much lower-dimensional representation (embedding) of a high-dimensional dataset through non-linear…

Machine Learning · Computer Science 2021-08-24 Andrew Lensen , Bing Xue , Mengjie Zhang

Recent work has proven the existence of extreme inbreeding in a European ancestry sample taken from the contemporary UK population \cite{nature_01}. This result brings our attention again to a math problem related to inbreeding family trees…

Populations and Evolution · Quantitative Biology 2021-09-08 C. Jarne , F A. Gómez Albarracín , M. Caruso

DNA sequences are fundamental for encoding genetic information. The genetic information may not only be understood by symbolic sequences but also from the hidden signals inside the sequences. The symbolic sequences need to be transformed…

Computational Engineering, Finance, and Science · Computer Science 2017-12-20 Changchuan Yin

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2023-04-21 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the…

Other Quantitative Biology · Quantitative Biology 2013-07-23 Nadya Morozova , Mikhail Shubin

We formulate code concatenation as the action of a unitary quantum circuit on an expanding tree geometry and find that for certain classes of gates, applied identically at each node, a binary tree circuit encodes a single logical qubit with…

Quantum Physics · Physics 2025-10-03 Grace M. Sommers , David A. Huse , Michael J. Gullans

In evolutionary policy search, neural networks are usually represented using a direct mapping: each gene encodes one network weight. Indirect encoding methods, where each gene can encode for multiple weights, shorten the genome to reduce…

Neural and Evolutionary Computing · Computer Science 2024-12-13 Tarek Kunze , Paul Templier , Dennis G Wilson

A unique decoding algorithm for general AG codes, namely multipoint evaluation codes on algebraic curves, is presented. It is a natural generalization of the previous decoding algorithm which was only for one-point AG codes. As such, it…

Information Theory · Computer Science 2016-11-15 Kwankyu Lee , Maria Bras-Amorós , Michael E. O'Sullivan

Information is often encoded as an aperiodic chain of building blocks. Modern digital computers use bits as the building blocks, but in general the choice of building blocks depends on the nature of the information to be encoded. What are…

Quantum Physics · Physics 2007-05-23 Apoorva Patel

Biologists have long sought a way to explain how statistical properties of genetic sequences emerged and are maintained through evolution. On the one hand, non-random structures at different scales indicate a complex genome organisation. On…

Quantitative Methods · Quantitative Biology 2018-11-01 Giampaolo Cristadoro , Mirko Degli Esposti , Eduardo G. Altmann

The genetic information that dictates the structure and function of all life forms is encoded in the DNA. In 1953, Watson and Crick first presented the double helical structure of a DNA molecule. Their findings unearthed the desire to…

Genomics · Quantitative Biology 2023-05-16 Olaitan Akintunde , Trichina Tucker , Valerie J. Carabetta

Galled trees are widely studied as a recombination model in population genetics. This class of phylogenetic networks is generalized into galled networks by relaxing a structural condition. In this work, a linear recurrence formula is given…

Populations and Evolution · Quantitative Biology 2018-12-21 Andreas DM Gunawan , Jeyaram Rathin , Louxin Zhang

The construction of a channel code by using a source code with decoder side information is introduced. For the construction, any pair of encoder and decoder is available for a source code with decoder side information. A…

Information Theory · Computer Science 2017-04-18 Jun Muramatsu , Shigeki Miyake

Rapid advance of experimental techniques provides an unprecedented in-depth view into complex developmental processes. Still, little is known on how the complexity of multicellular organisms evolved by elaborating developmental programs and…

Molecular Networks · Quantitative Biology 2021-07-16 Somya Mani , Tsvi Tlusty

DNA sequences are prone to creating secondary structures by folding back on themselves by non-specific hybridization among its nucleotides. The formation of secondary structures makes the sequences chemically inactive towards synthesis and…

Information Theory · Computer Science 2022-11-30 Siddhartha Siddhiprada Bhoi , Paramapalli Udaya , Abhay Kumar Singh

Genetic data are frequently categorical and have complex dependence structures that are not always well understood. For this reason, clustering and classification based on genetic data, while highly relevant, are challenging statistical…

Methodology · Statistics 2016-06-13 Gabriela Bettella Cybis , Marcio Valk , Silvia Regina Costa Lopes

In a multicellular organism different cell types express a gene in different amounts. Samples from which gene expression levels can be measured typically contain a mixture of different cell types, the resulting measurements thus give only…

Quantitative Methods · Quantitative Biology 2017-08-09 Nico Riedel , Johannes Berg

This work aims at showing the relevance and the applications possibilities of the Fibonacci sequence, and also its q-deformed or quantum extension, in the study of the genetic code(s). First, after the presentation of a new formula, an…

Other Quantitative Biology · Quantitative Biology 2015-10-06 Tidjani Negadi

Genome sequencing is the basis for many modern biological and medicinal studies. With recent technological advances, metagenomics has become a problem of interest. This problem entails the analysis and reconstruction of multiple DNA…

Probability · Mathematics 2022-01-14 Marlee Herring
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