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Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown,…

Quantitative Methods · Quantitative Biology 2014-04-30 Bryan C. Daniels , Ilya Nemenman

We propose and illustrate a hierarchical Bayesian approach for matching statistical records observed on different occasions. We show how this model can be profitably adopted both in record linkage problems and in capture--recapture setups,…

Applications · Statistics 2011-07-29 Andrea Tancredi , Brunero Liseo

Many astronomical surveys prompt follow-up observations, but the decision process through which candidates are selected for follow-up can be difficult to model. This poses a challenge when inferring properties of the intrinsic population of…

Instrumentation and Methods for Astrophysics · Physics 2026-05-08 Reed Essick , Amanda M. Farah

Bayesian adaptive experimental design is a form of active learning, which chooses samples to maximize the information they give about uncertain parameters. Prior work has shown that other forms of active learning can suffer from active…

Unbiased, label-free proteomics is becoming a powerful technique for measuring protein expression in almost any biological sample. The output of these measurements after preprocessing is a collection of features and their associated…

From scientific experiments to online A/B testing, the previously observed data often affects how future experiments are performed, which in turn affects which data will be collected. Such adaptivity introduces complex correlations between…

Machine Learning · Statistics 2018-01-03 Xinkun Nie , Xiaoying Tian , Jonathan Taylor , James Zou

Probabilistic modeling is fundamental to the statistical analysis of complex data. In addition to forming a coherent description of the data-generating process, probabilistic models enable parameter inference about given data sets. This…

Populations and Evolution · Quantitative Biology 2018-05-01 Branden J. Olson , Frederick A. Matsen

A new version of the partial autocorrelation plot and a new family of subset autoregressive models are introduced. A comprehensive approach to model identification, estimation and diagnostic checking is developed for these models. These…

Statistics Theory · Mathematics 2016-11-07 A. Ian McLeod , Ying Zhang

In NLP, recent work has seen increased focus on spurious correlations between various features and labels in training data, and how these influence model behavior. However, the presence and effect of such correlations are typically examined…

Computation and Language · Computer Science 2023-06-06 Sofia Serrano , Jesse Dodge , Noah A. Smith

Backpropagation is widely used to train artificial neural networks, but its relationship to synaptic plasticity in the brain is unknown. Some biological models of backpropagation rely on feedback projections that are symmetric with…

Neurons and Cognition · Quantitative Biology 2023-02-08 Navid Shervani-Tabar , Robert Rosenbaum

Criteria for identifying optimal adjustment sets yielding consistent estimation with minimal asymptotic variance of average treatment effects in parametric and nonparametric models have recently been established. In a single treatment time…

Statistics Theory · Mathematics 2025-10-06 David Adenyo , Mireille E Schnitzer , David Berger , Jason R Guertin , Denis Talbot

Since the beginning of the 21st century, the size, breadth, and granularity of data in biology and medicine has grown rapidly. In the example of neuroscience, studies with thousands of subjects are becoming more common, which provide…

In an indirect Gaussian sequence space model lower and upper bounds are derived for the concentration rate of the posterior distribution of the parameter of interest shrinking to the parameter value $\theta^\circ$ that generates the data.…

Statistics Theory · Mathematics 2015-02-03 Jan Johannes , Anna Simoni , Rudolf Schenk

Meta-analysis represents a widely accepted approach for evaluating the accuracy of diagnostic tools in clinical and psychological investigations. This paper investigates the applicability of multinomial tree models recently suggested in the…

Methodology · Statistics 2024-05-29 Annamaria Guolo

Anomaly detection to recognize unusual events in large scale systems in a time sensitive manner is critical in many industries, eg. bank fraud, enterprise systems, medical alerts, etc. Large-scale systems often grow in size and complexity…

Machine Learning · Computer Science 2022-10-31 Srishti Mishra , Tvarita Jain , Dinkar Sitaram

Linearly transforming stimulus representations of deep neural networks yields high-performing models of behavioral and neural responses to complex stimuli. But does the test accuracy of such predictions identify genuine representational…

Neurons and Cognition · Quantitative Biology 2026-01-05 Itamar Avitan , Tal Golan

Individuals do not respond uniformly to treatments, events, or interventions. Sociologists routinely partition samples into subgroups to explore how the effects of treatments vary by covariates like race, gender, and socioeconomic status.…

Other Statistics · Statistics 2019-09-23 Jennie E. Brand , Jiahui Xu , Bernard Koch , Pablo Geraldo

Many diverse phenomena in nature often inherently encode both short- and long-term temporal dependencies, which especially result from the direction of the flow of time. In this respect, we discovered experimental evidence suggesting that…

Artificial Intelligence · Computer Science 2025-02-11 Kyung Geun Kim , Byeong Tak Lee

In many scenarios, the observational data needed for causal inferences are spread over two data files. In particular, we consider scenarios where one file includes covariates and the treatment measured on one set of individuals, and a…

Methodology · Statistics 2020-09-22 Sharmistha Guha , Jerome P. Reiter , Andrea Mercatanti

Biological oscillations are periodic changes in various signaling processes crucial for the proper functioning of living organisms. These oscillations are modeled by ordinary differential equations, with coefficient variations leading to…

Machine Learning · Computer Science 2024-12-04 Heng Rao , Yu Gu , Jason Zipeng Zhang , Ge Yu , Yang Cao , Minghan Chen