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Basic principles of statistical inference are commonly violated in network data analysis. Under the current approach, it is often impossible to identify a model that accommodates known empirical behaviors, possesses crucial inferential…

Statistics Theory · Mathematics 2017-01-02 Harry Crane , Walter Dempsey

Networks are fundamental to the study of complex systems, ranging from social contacts, message transactions, to biological regulations and economical networks. In many realistic applications, these networks may vary over time. Modeling and…

Social and Information Networks · Computer Science 2020-04-07 Kun Tu , Jian Li , Don Towsley , Dave Braines , Liam Turner

Graphical lasso is one of the most used estimators for inferring genetic networks. Despite its diffusion, there are several fields in applied research where the limits of detection of modern measurement technologies make the use of this…

Methodology · Statistics 2019-11-18 Luigi Augugliaro , Antonino Abbruzzo , Veronica Vinciotti

Gene regulatory networks are collections of genes that interact with one other and with other substances in the cell. By measuring gene expression over time using high-throughput technologies, it may be possible to reverse engineer, or…

Applications · Statistics 2011-09-08 Andrea Rau , Florence Jaffrézic , Jean-Louis Foulley , R. W. Doerge

We consider the problem of identifying the topology of a weighted, undirected network $\mathcal G$ from observing snapshots of multiple independent consensus dynamics. Specifically, we observe the opinion profiles of a group of agents for a…

Social and Information Networks · Computer Science 2019-02-12 Santiago Segarra , Michael T. Schaub , Ali Jadbabaie

Gene regulatory networks typically have low in-degrees, whereby any given gene is regulated by few of the genes in the network. They also tend to have broad distributions for the out-degree. What mechanisms might be responsible for these…

Molecular Networks · Quantitative Biology 2013-05-29 Z. Burda , A. Krzywicki , O. C. Martin , M. Zagorski

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

We devise a machine learning technique to solve the general problem of inferring network links that have time-delays. The goal is to do this purely from time-series data of the network nodal states. This task has applications in fields…

Adaptation and Self-Organizing Systems · Physics 2021-07-28 Amitava Banerjee , Joseph D. Hart , Rajarshi Roy , Edward Ott

Bayesian graphical models are powerful tools to infer complex relationships in high dimension, yet are often fraught with computational and statistical challenges. If exploited in a principled way, the increasing information collected…

Methodology · Statistics 2024-03-15 Xiaoyue Xi , Hélène Ruffieux

The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. It is found that there are…

Molecular Networks · Quantitative Biology 2009-11-11 Ovidiu Lipan , Wing H. Wong

Reconstruction of gene regulatory networks is the process of identifying gene dependency from gene expression profile through some computation techniques. In our human body, though all cells pose similar genetic material but the activation…

A key question in many network studies is whether the observed correlations between units are primarily due to contagion or latent confounding. Here, we study this question using a segregated graph (Shpitser, 2015) representation of these…

Machine Learning · Computer Science 2025-03-07 Yufeng Wu , Rohit Bhattacharya

Inferring the structure of gene regulatory networks (GRN) from gene expression data has many applications, from the elucidation of complex biological processes to the identification of potential drug targets. It is however a notoriously…

Machine Learning · Statistics 2012-05-08 Anne-Claire Haury , Fantine Mordelet , Paola Vera-Licona , Jean-Philippe Vert

Connectivity structure shapes neural computation, but inferring this structure from population recordings is degenerate: multiple connectivity structures can generate identical dynamics. Recent work uses low-rank recurrent neural networks…

Neurons and Cognition · Quantitative Biology 2026-03-30 Timothy Doyeon Kim , Ulises Pereira-Obilinovic , Yiliu Wang , Eric Shea-Brown , Uygar Sümbül

Contagion processes are strongly linked to the network structures on which they propagate, and learning these structures is essential for understanding and intervention on complex network processes such as epidemics and (mis)information…

Social and Information Networks · Computer Science 2019-08-12 Caitlin Gray , Lewis Mitchell , Matthew Roughan

This paper addresses the problem of inferring sparse causal networks modeled by multivariate auto-regressive (MAR) processes. Conditions are derived under which the Group Lasso (gLasso) procedure consistently estimates sparse network…

Machine Learning · Statistics 2015-05-28 Andrew Bolstad , Barry Van Veen , Robert Nowak

Bayesian belief networks can be used to represent and to reason about complex systems with uncertain, incomplete and conflicting information. Belief networks are graphs encoding and quantifying probabilistic dependence and conditional…

Artificial Intelligence · Computer Science 2013-03-08 Carlos Rojas-Guzman , Mark A. Kramer

Traditionally, statistical and causal inference on human subjects rely on the assumption that individuals are independently affected by treatments or exposures. However, recently there has been increasing interest in settings, such as…

Methodology · Statistics 2020-02-25 Elizabeth L. Ogburn , Ilya Shpitser , Youjin Lee

Time plays an essential role in the diffusion of information, influence and disease over networks. In many cases we only observe when a node copies information, makes a decision or becomes infected -- but the connectivity, transmission…

Social and Information Networks · Computer Science 2011-05-05 Manuel Gomez Rodriguez , David Balduzzi , Bernhard Schölkopf

We develop a matrix-based approach to predict and verify indirect interactions in gene and protein regulatory networks. It is based on the approximate transitivity of indirect regulations (e.g. A regulates B and B regulates C often implies…

Quantitative Methods · Quantitative Biology 2007-11-27 Koon-Kiu Yan , Sergei Maslov , Ilya Mazo , Anton Yuryev