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Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemical logic gates based on enzymatic reactions, and a network of…

Molecular Networks · Quantitative Biology 2010-09-22 Mary A. Arugula , Jan Halamek , Evgeny Katz , Dmitriy Melnikov , Marcos Pita , Vladimir Privman , Guinevere Strack

We review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in…

Biological Physics · Physics 2010-10-12 Evgeny Katz , Vladimir Privman

We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymatic AND gates are reported, illustrating our procedure.…

Molecular Networks · Quantitative Biology 2010-10-12 Vladimir Privman , Mary A. Arugula , Jan Halamek , Marcos Pita , Evgeny Katz

Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this work we survey filtering in general, in biochemical computing,…

We review models and approaches for error-control in order to prevent the buildup of noise when gates for digital chemical and biomolecular computing based on (bio)chemical reaction processes are utilized to realize stable, scalable…

Soft Condensed Matter · Physics 2011-02-15 Vladimir Privman

We consider approaches for controlling the buildup of noise by design of gates for chemical and biomolecular computing, in order to realize stable, scalable networks for multi-step information processing. Solvable rate-equation models are…

Biological Physics · Physics 2011-02-28 Vladimir Privman

Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking these gates and coupling of the…

Biological Physics · Physics 2010-10-12 Vladimir Privman , Evgeny Katz , Joseph Wang

Recent years have witnessed the growing scholarly interest in the next-generation general-purpose computers. Various innovative computing modes have been proposed, such as optical, quantum phenomena, and DNA-based modes. Sequential logic…

Emerging Technologies · Computer Science 2026-01-01 Han Huang , Chengzhi Ma , Yuxin Zhao , Qingyao Wang , Xinglong Xiao , Xiulin Shu , Zhifeng Hao

Computing based on biochemical processes is a newest rapidly developing field of unconventional information and signal processing. In this paper we present results of our research in the field of biochemical computing and summarize the…

Nanomechanical computers promise robust, low energy information processing. However, to date, electronics have generally been required to interconnect gates, while no scalable, purely nanomechanical approach to computing has been achieved.…

In this work we demonstrate both experimentally and theoretically that the analog noise generation by a single enzymatic logic gate can be dramatically reduced to yield gate operation with virtually no input noise amplification. This is…

Molecular Networks · Quantitative Biology 2010-10-12 Dmitriy Melnikov , Guinevere Strack , Marcos Pita , Vladimir Privman , Evgeny Katz

We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output allowing to make the gate's response sigmoid in both inputs. New functional forms are…

Soft Condensed Matter · Physics 2013-11-05 Vladimir Privman , Brian E. Fratto , Oleksandr Zavalov , Jan Halamek , Evgeny Katz

We explore a method for automatically recompiling a quantum circuit A into a target circuit B, with the goal that both circuits have the same action on a specific input i.e. B|in> = A|in>. This is of particular relevance to hybrid, NISQ-era…

Quantum Physics · Physics 2022-01-26 Tyson Jones , Simon C Benjamin

Quantum machine learning offers promising advantages for classification tasks, but noise, decoherence, and connectivity constraints in current devices continue to limit the efficient execution of feature map-based circuits. Gate Assessment…

Machine Learning · Computer Science 2026-03-23 F. Rodríguez-Díaz , D. Gutiérrez-Avilés , A. Troncoso , F. Martínez-Álvarez

While quantum computing holds great potential in combinatorial optimization, electronic structure calculation, and number theory, the current era of quantum computing is limited by noisy hardware. Many quantum compilation approaches can…

Quantum Physics · Physics 2024-08-13 Max Aksel Bowman , Pranav Gokhale , Jeffrey Larson , Ji Liu , Martin Suchara

This paper proposes the use of Eukaryotic cells, namely astrocytes, to develop logic gates. The logic gates are achieved by manipulating the threshold of Ca$^{2+}$ ion flows between the cells, based on the input signals. Through wet-lab…

We consider a realization of the XOR logic gate in a system involving two competing biocatalytic reactions, for which the logic-1 output is defined by these two processes causing a change in the optically detected signal. A model is…

Soft Condensed Matter · Physics 2010-11-09 Vladimir Privman , Jian Zhou , Jan Halamek , Evgeny Katz

Recent experimental breakthroughs have finally allowed to implement in-vitro reaction kinetics (the so called {\em enzyme based logic}) which code for two-inputs logic gates and mimic the stochastic AND (and NAND) as well as the stochastic…

Disordered Systems and Neural Networks · Physics 2016-02-02 Elena Agliari , Matteo Altavilla , Adriano Barra , Lorenzo Dello Schiavo , Evgeny Katz

Implementing quantum algorithms on realistic hardware requires translating high-level global operations into sequences of native elementary gates, a process known as quantum compiling. Physical limitations, such as constraints in…

The reliability of logical operations is indispensable for the reliable operation of computational systems. Since the down-sizing of micro-fabrication generates non-negligible noise in these systems, a new approach for designing…

Other Computer Science · Computer Science 2020-04-22 Tetsuya J. Kobayashi
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